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HUMAN:CNOT4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CNOT4 (synonyms: NOT4)
Protein Name(s) CCR4-NOT transcription complex subunit 4

CCR4-associated factor 4 E3 ubiquitin-protein ligase CNOT4 Potential transcriptional repressor NOT4Hp

External Links
UniProt O95628
EMBL U71267
U71268
AF180475
AL389980
AK074671
AK300365
AC083871
AC074002
BC035590
AF091094
CCDS CCDS43650.1
CCDS47719.1
CCDS55164.1
CCDS55165.1
CCDS55166.1
CCDS55167.1
RefSeq NP_001008226.1
NP_001177776.1
NP_001177777.1
NP_001177778.1
NP_001177779.1
NP_037448.2
UniGene Hs.490224
PDB 1E4U
1UR6
PDBsum 1E4U
1UR6
ProteinModelPortal O95628
SMR O95628
BioGrid 110912
IntAct O95628
STRING 9606.ENSP00000354673
PhosphoSite O95628
MaxQB O95628
PaxDb O95628
PRIDE O95628
Ensembl ENST00000315544
ENST00000361528
ENST00000414802
ENST00000423368
ENST00000428680
ENST00000451834
ENST00000541284
GeneID 4850
KEGG hsa:4850
UCSC uc003vss.3
uc003vst.3
uc003vsu.2
uc003vsv.2
CTD 4850
GeneCards GC07M135046
H-InvDB HIX0007112
HGNC HGNC:7880
HPA HPA005737
MIM 604911
neXtProt NX_O95628
PharmGKB PA26675
eggNOG COG5175
GeneTree ENSGT00390000000068
HOVERGEN HBG051043
InParanoid O95628
KO K10643
OMA ASWNPYS
OrthoDB EOG790G0K
PhylomeDB O95628
TreeFam TF106134
Reactome REACT_20514
UniPathway UPA00143
EvolutionaryTrace O95628
GenomeRNAi 4850
NextBio 18678
PRO PR:O95628
Proteomes UP000005640
Bgee O95628
CleanEx HS_CNOT4
ExpressionAtlas O95628
Genevestigator O95628
GO GO:0005829
GO:0005634
GO:0016874
GO:0000166
GO:0044822
GO:0004842
GO:0008270
GO:0010467
GO:0016071
GO:0000288
GO:0000289
GO:0051865
GO:0016070
Gene3D 3.30.40.10
3.30.70.330
InterPro IPR012677
IPR000504
IPR000571
IPR001841
IPR013083
SMART SM00184
SM00360
PROSITE PS50102
PS50103
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:26575292[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045652

regulation of megakaryocyte differentiation

PMID:26575292[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:26575292[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

PMID:15001359[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

colocalizes_with

GO:0030014

CCR4-NOT complex

PMID:19558367[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:15001359[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030014

CCR4-NOT complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288208
PomBase:SPAC16C9.04c
UniProtKB:O95628

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288208
SGD:S000000870

P

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288208
SGD:S000000870
UniProtKB:O95628

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR003954
InterPro:IPR035979

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039780

F

Seeded From UniProt

complete

part_of

GO:0030014

CCR4-NOT complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039780

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000571

F

Seeded From UniProt

complete

involved_in

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Reactome:R-HSA-6791312

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-6798044
Reactome:R-HSA-429955

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0000289

nuclear-transcribed mRNA poly(A) tail shortening

Reactome:R-HSA-429947

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Zhang, L et al. (2015) Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. Elife 4 PubMed GONUTS page
  2. ↑ 2.0 2.1 Winkler, GS et al. (2004) An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair. J. Mol. Biol. 337 157-65 PubMed GONUTS page
  3. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  4. ↑ Lau, NC et al. (2009) Human Ccr4-Not complexes contain variable deadenylase subunits. Biochem. J. 422 443-53 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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