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HUMAN:CNBP1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CTNNBIP1 (synonyms: ICAT) | |
| Protein Name(s) | Beta-catenin-interacting protein 1
Inhibitor of beta-catenin and Tcf-4 | |
| External Links | ||
| UniProt | Q9NSA3 | |
| EMBL | AB021262 AL357140 CH471130 BC014300 BC146892 BC146896 | |
| CCDS | CCDS106.1 | |
| RefSeq | NP_001012329.1 NP_064633.1 XP_006710842.1 | |
| UniGene | Hs.463759 | |
| PDB | 1LUJ 1M1E 1T08 | |
| PDBsum | 1LUJ 1M1E 1T08 | |
| ProteinModelPortal | Q9NSA3 | |
| SMR | Q9NSA3 | |
| BioGrid | 121313 | |
| IntAct | Q9NSA3 | |
| MINT | MINT-249497 | |
| STRING | 9606.ENSP00000366466 | |
| PhosphoSite | Q9NSA3 | |
| DMDM | 29428025 | |
| MaxQB | Q9NSA3 | |
| PaxDb | Q9NSA3 | |
| PeptideAtlas | Q9NSA3 | |
| PRIDE | Q9NSA3 | |
| DNASU | 56998 | |
| Ensembl | ENST00000377256 ENST00000377258 ENST00000377263 ENST00000400904 | |
| GeneID | 56998 | |
| KEGG | hsa:56998 | |
| UCSC | uc001aqk.1 | |
| CTD | 56998 | |
| GeneCards | GC01M009908 | |
| HGNC | HGNC:16913 | |
| HPA | CAB024893 HPA042617 | |
| MIM | 607758 | |
| neXtProt | NX_Q9NSA3 | |
| PharmGKB | PA27014 | |
| eggNOG | NOG39852 | |
| GeneTree | ENSGT00510000048990 | |
| HOGENOM | HOG000037432 | |
| HOVERGEN | HBG051037 | |
| InParanoid | Q9NSA3 | |
| KO | K04493 | |
| OMA | SHEEMYI | |
| OrthoDB | EOG71P2DG | |
| PhylomeDB | Q9NSA3 | |
| Reactome | REACT_200731 | |
| EvolutionaryTrace | Q9NSA3 | |
| GeneWiki | CTNNBIP1 | |
| GenomeRNAi | 56998 | |
| NextBio | 62715 | |
| PRO | PR:Q9NSA3 | |
| Proteomes | UP000005640 | |
| Bgee | Q9NSA3 | |
| CleanEx | HS_CTNNBIP1 | |
| ExpressionAtlas | Q9NSA3 | |
| Genevestigator | Q9NSA3 | |
| GO | GO:0030877 GO:0005737 GO:0005829 GO:0005634 GO:0070016 GO:0008013 GO:0009952 GO:0001658 GO:0043392 GO:0072201 GO:0032091 GO:0043433 GO:0048662 GO:0060633 GO:0030178 GO:0045657 GO:0045669 GO:0002528 GO:0016055 | |
| Gene3D | 1.10.10.490 | |
| InterPro | IPR009428 | |
| Pfam | PF06384 | |
| SUPFAM | SSF81730 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0072201 |
negative regulation of mesenchymal cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070016 |
armadillo repeat domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045669 |
positive regulation of osteoblast differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045657 |
positive regulation of monocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032091 |
negative regulation of protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032091 |
negative regulation of protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030877 |
beta-catenin destruction complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002528 |
regulation of vascular permeability involved in acute inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030877 |
beta-catenin destruction complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002932292 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030178 |
negative regulation of Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1915756 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1915756 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002932292 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002932292 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060633 |
negative regulation of transcription initiation from RNA polymerase II promoter |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043392 |
negative regulation of DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031333 |
negative regulation of protein complex assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030178 |
negative regulation of Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009952 |
anterior/posterior pattern specification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001658 |
branching involved in ureteric bud morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJN6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-3772430 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Kim, YJ et al. (2008) ICAT participates in proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cell. Life Sci. 83 851-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Daniels, DL & Weis, WI (2002) ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol. Cell 10 573-84 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Wang, W et al. (2009) ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657. Cell Biochem. Funct. 27 329-37 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Guo, M et al. (2008) VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability. Am. J. Physiol., Cell Physiol. 294 C977-84 PubMed GONUTS page
- ↑ Penman, GA et al. (2005) The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J. Cell. Sci. 118 4741-50 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
a
b
n
- GO:0072201 ! negative regulation of mesenchymal cell proliferation
- GO:0031333 ! negative regulation of protein-containing complex assembly
- GO:0043433 ! negative regulation of DNA-binding transcription factor activity
- GO:0032091 ! negative regulation of protein binding
- GO:0030178 ! negative regulation of Wnt signaling pathway
- GO:0060633 ! negative regulation of transcription initiation by RNA polymerase II
- GO:0048662 ! negative regulation of smooth muscle cell proliferation
- GO:0043392 ! negative regulation of DNA binding
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
p
