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HUMAN:CLK2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CLK2
Protein Name(s) Dual specificity protein kinase CLK2

CDC-like kinase 2

External Links
UniProt P49760
EMBL L29218
L29216
AF023268
AL713999
BC014067
BC053603
CCDS CCDS1107.1
CCDS72939.1
PIR S53637
S53638
RefSeq NP_001281267.1
NP_001281268.1
NP_003984.2
UniGene Hs.73986
PDB 3NR9
PDBsum 3NR9
ProteinModelPortal P49760
SMR P49760
BioGrid 107607
IntAct P49760
MINT MINT-1683264
STRING 9606.ENSP00000354856
BindingDB P49760
ChEMBL CHEMBL4225
GuidetoPHARMACOLOGY 1991
PhosphoSite P49760
DMDM 1705919
MaxQB P49760
PaxDb P49760
PRIDE P49760
DNASU 1196
Ensembl ENST00000361168
ENST00000368361
ENST00000572269
ENST00000574445
GeneID 1196
KEGG hsa:1196
UCSC uc001fjw.3
uc001fjx.3
CTD 1196
GeneCards GC01M155232
H-InvDB HIX0001112
HGNC HGNC:2069
HPA HPA055366
MIM 602989
neXtProt NX_P49760
PharmGKB PA26595
eggNOG COG0515
GeneTree ENSGT00580000081366
HOGENOM HOG000203417
HOVERGEN HBG107720
InParanoid P49760
KO K08823
OMA GHLIYRV
PhylomeDB P49760
TreeFam TF101041
BRENDA 2.7.12.1
SignaLink P49760
ChiTaRS CLK2
EvolutionaryTrace P49760
GeneWiki CLK2
GenomeRNAi 1196
NextBio 4940
PRO PR:P49760
Proteomes UP000005640
UP000005640
Bgee P49760
CleanEx HS_CLK2
ExpressionAtlas P49760
Genevestigator P49760
GO GO:0016607
GO:0005634
GO:0005524
GO:0004674
GO:0004712
GO:0004713
GO:0045721
GO:0046777
GO:0006468
GO:0043484
GO:0010212
GO:0032526
InterPro IPR011009
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0046777

protein autophosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O35491

P

Seeded From UniProt

complete

involved_in

GO:0045721

negative regulation of gluconeogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O35491

P

Seeded From UniProt

complete

involved_in

GO:0043484

regulation of RNA splicing

PMID:9637771[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010212

response to ionizing radiation

PMID:20682768[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:9637771[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:20682768[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9637771[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:10480872[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P49760

F

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35491
ensembl:ENSMUSP00000113390

P

Seeded From UniProt

complete

involved_in

GO:0045721

negative regulation of gluconeogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35491
ensembl:ENSMUSP00000113390

P

Seeded From UniProt

complete

involved_in

GO:0032526

response to retinoic acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35491
ensembl:ENSMUSP00000113390

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35491
ensembl:ENSMUSP00000113390

P

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35491
ensembl:ENSMUSP00000113390

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35491
ensembl:ENSMUSP00000113390

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35491
ensembl:ENSMUSP00000113390

C

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35491
ensembl:ENSMUSP00000113390

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35491
ensembl:ENSMUSP00000113390

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0004712

protein serine/threonine/tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.12.1

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:7990150[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0186

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Duncan, PI et al. (1998) The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. Exp. Cell Res. 241 300-8 PubMed GONUTS page
  2. ↑ 2.0 2.1 Nam, SY et al. (2010) Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation. J. Biol. Chem. 285 31157-63 PubMed GONUTS page
  3. ↑ Moeslein, FM et al. (1999) The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. J. Biol. Chem. 274 26697-704 PubMed GONUTS page
  4. ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  5. ↑ Hanes, J et al. (1994) Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. J. Mol. Biol. 244 665-72 PubMed GONUTS page
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