GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:CDN2C
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CDKN2C (synonyms: CDKN6) | |
| Protein Name(s) | Cyclin-dependent kinase 4 inhibitor C
Cyclin-dependent kinase 6 inhibitor p18-INK4c p18-INK6 | |
| External Links | ||
| UniProt | P42773 | |
| EMBL | U17074 AF041248 AF041250 AF041249 AY094608 BC000598 BC005041 BC016173 | |
| CCDS | CCDS555.1 | |
| PIR | A55479 | |
| RefSeq | NP_001253.1 NP_523240.1 | |
| UniGene | Hs.525324 | |
| PDB | 1BU9 1G3N 1IHB 1MX2 1MX4 1MX6 | |
| PDBsum | 1BU9 1G3N 1IHB 1MX2 1MX4 1MX6 | |
| ProteinModelPortal | P42773 | |
| SMR | P42773 | |
| BioGrid | 107465 | |
| IntAct | P42773 | |
| MINT | MINT-1372629 | |
| STRING | 9606.ENSP00000262662 | |
| PhosphoSite | P42773 | |
| DMDM | 1168870 | |
| MaxQB | P42773 | |
| PaxDb | P42773 | |
| PRIDE | P42773 | |
| DNASU | 1031 | |
| Ensembl | ENST00000262662 ENST00000371761 ENST00000396148 | |
| GeneID | 1031 | |
| KEGG | hsa:1031 | |
| UCSC | uc001csf.3 | |
| CTD | 1031 | |
| GeneCards | GC01P051427 | |
| HGNC | HGNC:1789 | |
| HPA | CAB005303 CAB018398 HPA019057 HPA019764 | |
| MIM | 603369 | |
| neXtProt | NX_P42773 | |
| Orphanet | 652 | |
| PharmGKB | PA26322 | |
| eggNOG | COG0666 | |
| HOGENOM | HOG000290191 | |
| HOVERGEN | HBG050870 | |
| InParanoid | P42773 | |
| KO | K06622 | |
| OMA | LMKHTAC | |
| OrthoDB | EOG7ZSHVC | |
| PhylomeDB | P42773 | |
| TreeFam | TF333311 | |
| Reactome | REACT_169168 REACT_169325 REACT_169436 REACT_821 | |
| EvolutionaryTrace | P42773 | |
| GeneWiki | CDKN2C | |
| GenomeRNAi | 1031 | |
| NextBio | 4337 | |
| PRO | PR:P42773 | |
| Proteomes | UP000005640 | |
| Bgee | P42773 | |
| CleanEx | HS_CDKN2C | |
| ExpressionAtlas | P42773 | |
| Genevestigator | P42773 | |
| GO | GO:0005737 GO:0005829 GO:0005634 GO:0004861 GO:0019901 GO:0007050 GO:0000082 GO:0000278 GO:0030308 GO:0008285 GO:0042326 GO:0071901 GO:0048709 GO:0000079 | |
| Gene3D | 1.25.40.20 | |
| InterPro | IPR002110 IPR020683 | |
| Pfam | PF00023 | |
| SMART | SM00248 | |
| SUPFAM | SSF48403 | |
| PROSITE | PS50297 PS50088 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0042326 |
negative regulation of phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030308 |
negative regulation of cell growth |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007050 |
cell cycle arrest |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004861 |
cyclin-dependent protein serine/threonine kinase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000082 |
G1/S transition of mitotic cell cycle |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000079 |
regulation of cyclin-dependent protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045736 |
negative regulation of cyclin-dependent protein serine/threonine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60772 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60772 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60772 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004861 |
cyclin-dependent protein serine/threonine kinase inhibitor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60772 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048709 |
oligodendrocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R5G4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000134 |
negative regulation of G1/S transition of mitotic cell cycle |
Reactome:R-HSA-182594 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-182594 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Schreiber, M et al. (1999) Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. Oncogene 18 1663-76 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Guan, KL et al. (1994) Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8 2939-52 PubMed GONUTS page
- ↑ 3.0 3.1 Korshunov, A & Golanov, A (2002) Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome. Arch. Pathol. Lab. Med. 126 42-8 PubMed GONUTS page
c
n
- GO:0030308 ! negative regulation of cell growth
- GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle
- GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0042326 ! negative regulation of phosphorylation
- GO:0005634 ! nucleus
