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HUMAN:CDC6

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CDC6 (synonyms: CDC18L)
Protein Name(s) Cell division control protein 6 homolog

CDC6-related protein Cdc18-related protein HsCdc18 p62(cdc6) HsCDC6

External Links
UniProt Q99741
EMBL U77949
AF022109
AY150310
BC025232
CCDS CCDS11365.1
RefSeq NP_001245.1
UniGene Hs.405958
PDB 2CCH
2CCI
4I5L
4I5N
PDBsum 2CCH
2CCI
4I5L
4I5N
ProteinModelPortal Q99741
SMR Q99741
BioGrid 107426
DIP DIP-28154N
IntAct Q99741
MINT MINT-1201847
STRING 9606.ENSP00000209728
ChEMBL CHEMBL2311228
PhosphoSite Q99741
DMDM 50400620
MaxQB Q99741
PaxDb Q99741
PRIDE Q99741
DNASU 990
Ensembl ENST00000209728
GeneID 990
KEGG hsa:990
UCSC uc002huj.1
CTD 990
GeneCards GC17P038443
HGNC HGNC:1744
HPA HPA050114
HPA054703
MIM 602627
613805
neXtProt NX_Q99741
Orphanet 2554
PharmGKB PA26271
eggNOG COG1474
GeneTree ENSGT00530000063498
HOGENOM HOG000045316
HOVERGEN HBG050860
InParanoid Q99741
KO K02213
OMA TPHLPPC
OrthoDB EOG7QG44J
PhylomeDB Q99741
TreeFam TF101051
Reactome REACT_1095
REACT_111214
REACT_1156
REACT_1181
REACT_1221
REACT_1707
REACT_1949
REACT_207
REACT_2243
REACT_471
REACT_6769
REACT_683
SignaLink Q99741
ChiTaRS CDC6
EvolutionaryTrace Q99741
GeneWiki CDC6
GenomeRNAi 990
NextBio 4156
PMAP-CutDB Q99741
PRO PR:Q99741
Proteomes UP000005640
Bgee Q99741
CleanEx HS_CDC6
ExpressionAtlas Q99741
Genevestigator Q99741
GO GO:0005737
GO:0005829
GO:0005794
GO:0005654
GO:0005634
GO:0051233
GO:0000922
GO:0005524
GO:0003682
GO:0019900
GO:0000166
GO:0006260
GO:0000076
GO:0000082
GO:0000278
GO:0007067
GO:0008285
GO:0008156
GO:0051984
GO:0032467
GO:0000079
GO:0030071
GO:0000083
GO:0007089
Gene3D 1.10.10.10
3.40.50.300
InterPro IPR003593
IPR015163
IPR016314
IPR027417
IPR011991
Pfam PF09079
PIRSF PIRSF001767
SMART SM00382
SM01074
SUPFAM SSF52540

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

incorrect (CACAO)

GO:0005515

protein binding

PMID:15684404[1]

ECO:0000021

UniProtKB:Q9UJA3


F

Co-Immunoprecipitates from Figure 3

complete

part_of

GO:0005634

nucleus

PMID:21383955[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

NOT|part_of

GO:0005730

nucleolus

PMID:21383955[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:22581055[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051984

positive regulation of chromosome segregation

PMID:21041660[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0051233

spindle midzone

PMID:21041660[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032467

positive regulation of cytokinesis

PMID:21041660[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030071

regulation of mitotic metaphase/anaphase transition

PMID:21041660[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

PMID:21041660[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P06493

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21041660[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:21041660[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0033314

mitotic DNA replication checkpoint

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000080055
PomBase:SPBC14C8.07c
PomBase:SPBC29A10.15

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035918
PANTHER:PTN000080129
PomBase:SPBC14C8.07c
UniProtKB:Q99741
WB:WBGene00000382

C

Seeded From UniProt

complete

enables

GO:0003688

DNA replication origin binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000080055
PomBase:SPBC29A10.15
SGD:S000003730
SGD:S000004530
UniProtKB:Q8I615

F

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000080055
UniProtKB:Q99741

P

Seeded From UniProt

complete

involved_in

GO:1904385

cellular response to angiotensin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZRK7
ensembl:ENSRNOP00000071363

P

Seeded From UniProt

complete

involved_in

GO:1904117

cellular response to vasopressin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZRK7
ensembl:ENSRNOP00000071363

P

Seeded From UniProt

complete

involved_in

GO:0048146

positive regulation of fibroblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZRK7
ensembl:ENSRNOP00000071363

P

Seeded From UniProt

complete

involved_in

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZRK7
ensembl:ENSRNOP00000071363

P

Seeded From UniProt

complete

involved_in

GO:0006270

DNA replication initiation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016314

P

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016314

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:9566895[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008156

negative regulation of DNA replication

PMID:9566895[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007089

traversing start control point of mitotic cell cycle

PMID:9566895[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:9566895[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9566895[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

PMID:8990175[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:9566895[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000076

DNA replication checkpoint

PMID:9566895[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

Reactome:R-HSA-176318

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-69016
Reactome:R-HSA-69015
Reactome:R-HSA-69006

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8961619
Reactome:R-HSA-69006
Reactome:R-HSA-69005
Reactome:R-HSA-68944
Reactome:R-HSA-68940
Reactome:R-HSA-68919
Reactome:R-HSA-68918
Reactome:R-HSA-68917
Reactome:R-HSA-68916
Reactome:R-HSA-68849
Reactome:R-HSA-68826
Reactome:R-HSA-68688
Reactome:R-HSA-68637
Reactome:R-HSA-176318
Reactome:R-HSA-176298

ECO:0000304

author statement supported by traceable reference used in manual assertion















C

Seeded From UniProt

complete

involved_in

GO:0000083

regulation of transcription involved in G1/S transition of mitotic cell cycle

Reactome:R-HSA-69205

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

Reactome:R-HSA-69206

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

GO:1902315

DNA replication initiation involved in nuclear cell cycle DNA replication

PMID:23479742[8]

ECO:0000314

P

Figure 5

complete
CACAO 9195

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Volkening, M & Hoffmann, I (2005) Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin. Mol. Cell. Biol. 25 1560-8 PubMed GONUTS page
  2. ↑ 2.0 2.1 Bronze-da-Rocha, E et al. (2011) Interactions of MCP1 with components of the replication machinery in mammalian cells. Int. J. Biol. Sci. 7 193-208 PubMed GONUTS page
  3. ↑ Varma, D et al. (2012) Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Nat. Cell Biol. 14 593-603 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Yim, H & Erikson, RL (2010) Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. Proc. Natl. Acad. Sci. U.S.A. 107 19742-7 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Saha, P et al. (1998) Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol. Cell. Biol. 18 2758-67 PubMed GONUTS page
  7. ↑ Williams, RS et al. (1997) A human protein related to yeast Cdc6p. Proc. Natl. Acad. Sci. U.S.A. 94 142-7 PubMed GONUTS page
  8. ↑ Zou, Y et al. (2013) CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J. Cell Biol. 200 743-56 PubMed GONUTS page
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