HUMAN:CD9

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CD9 (synonyms: MIC3, TSPAN29)
Protein Name(s)	CD9 antigen 5H9 antigen Cell growth-inhibiting gene 2 protein Leukocyte antigen MIC3 Motility-related protein MRP-1 Tetraspanin-29 Tspan-29 p24
External Links
UniProt	P21926
EMBL	M38690 L34068 X60111 S60489 S60462 S60463 S60464 S60700 S60699 S60465 S60472 L08118 L08119 L08120 L08121 L08122 L08123 L08124 L08125 AB079244 AY423720 AY422198 CH471116 CH471116 BC011988
CCDS	CCDS8540.1
PIR	A46123
RefSeq	NP_001760.1
UniGene	Hs.114286 Hs.712104
ProteinModelPortal	P21926
SMR	P21926
BioGrid	107366
DIP	DIP-1122N
IntAct	P21926
MINT	MINT-1527350
STRING	9606.ENSP00000009180
TCDB	8.A.40.1.9
PhosphoSite	P21926
DMDM	231724
MaxQB	P21926
PaxDb	P21926
PRIDE	P21926
DNASU	928
Ensembl	ENST00000009180 ENST00000382518
GeneID	928
KEGG	hsa:928
UCSC	uc001qnq.2
CTD	928
GeneCards	GC12P006308
HGNC	HGNC:1709
HPA	CAB002490
MIM	143030
neXtProt	NX_P21926
PharmGKB	PA26247
eggNOG	NOG242618
GeneTree	ENSGT00760000118983
HOGENOM	HOG000230651
HOVERGEN	HBG002324
InParanoid	P21926
KO	K06460
OMA	ALNCCGI
OrthoDB	EOG7FBRJV
PhylomeDB	P21926
TreeFam	TF352895
Reactome	REACT_164006
ChiTaRS	CD9
GeneWiki	CD9
GenomeRNAi	928
NextBio	3846
PRO	PR:P21926
Proteomes	UP000005640
Bgee	P21926
CleanEx	HS_CD9
ExpressionAtlas	P21926
Genevestigator	P21926
GO	GO:0016324 GO:0009897 GO:0005615 GO:0070062 GO:0005925 GO:0005887 GO:0005886 GO:0031092 GO:0031982 GO:0007596 GO:0007420 GO:0007155 GO:0006928 GO:0007342 GO:0032504 GO:0008285 GO:0014003 GO:0030913 GO:0030168 GO:0002576 GO:0009414 GO:0007338
Gene3D	1.10.1450.10
InterPro	IPR028977 IPR000301 IPR018499 IPR018503 IPR008952
Pfam	PF00335
PIRSF	PIRSF002419
PRINTS	PR00259
SUPFAM	SSF48652
PROSITE	PS00421

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40240	C		Seeded From UniProt	complete
involved_in	GO:0035036	sperm-egg recognition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40240	P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:12796480^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0014905	myoblast fusion involved in skeletal muscle regeneration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40240	P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:27993971^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090331	negative regulation of platelet aggregation	PMID:18541721^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40240	C		Seeded From UniProt	complete
involved_in	GO:0071404	cellular response to low-density lipoprotein particle stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40240	P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40240	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:15908444^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000178)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	PMID:24769233^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001359)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:15326289^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:6198179^[12]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030913	paranodal junction assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40240	P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	PMID:2037603^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	PMID:14575715^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:7511626^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051271	negative regulation of cellular component movement	PMID:8478605^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2037603^[13]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1889818 PANTHER:PTN001060286 UniProtKB:P60033	C		Seeded From UniProt	complete
involved_in	GO:1905521	regulation of macrophage migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	P		Seeded From UniProt	complete
involved_in	GO:0071404	cellular response to low-density lipoprotein particle stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	C		Seeded From UniProt	complete
involved_in	GO:0035036	sperm-egg recognition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	P		Seeded From UniProt	complete
involved_in	GO:0030913	paranodal junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	C		Seeded From UniProt	complete
involved_in	GO:0014905	myoblast fusion involved in skeletal muscle regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	P		Seeded From UniProt	complete
involved_in	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	P		Seeded From UniProt	complete
involved_in	GO:0007338	single fertilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40240 ensembl:ENSMUSP00000032492	F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40241 ensembl:ENSRNOP00000026633	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40241 ensembl:ENSRNOP00000026633	C		Seeded From UniProt	complete
involved_in	GO:0014003	oligodendrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40241 ensembl:ENSRNOP00000026633	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40241 ensembl:ENSRNOP00000026633	C		Seeded From UniProt	complete
involved_in	GO:0009414	response to water deprivation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40241 ensembl:ENSRNOP00000026633	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40241 ensembl:ENSRNOP00000026633	P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40241 ensembl:ENSRNOP00000026633	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000301 InterPro:IPR008952 InterPro:IPR018499 InterPro:IPR018503	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:1840589^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031092	platelet alpha granule membrane	Reactome:R-HSA-481044	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030669	clathrin-coated endocytic vesicle membrane	Reactome:R-HSA-5336422 Reactome:R-HSA-5336413	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-5336420 Reactome:R-HSA-5336413	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	Reactome:R-HSA-1300652	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5336422 Reactome:R-HSA-5336417 Reactome:R-HSA-481044 Reactome:R-HSA-1297275	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007338	single fertilization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0278	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0466	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Takeda, Y et al. (2003) Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J. Cell Biol. 161 945-56 PubMed GONUTS page
↑ Yu, J et al. (2017) The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3. Biochem. J. 474 589-596 PubMed GONUTS page
↑ Nakazawa, Y et al. (2008) Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis. Blood 112 1730-9 PubMed GONUTS page
↑ Caby, MP et al. (2005) Exosomal-like vesicles are present in human blood plasma. Int. Immunol. 17 879-87 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Pisitkun, T et al. (2004) Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U.S.A. 101 13368-73 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ Katz, F et al. (1983) Chromosome assignment of monoclonal antibody-defined determinants on human leukemic cells. Eur. J. Immunol. 13 1008-13 PubMed GONUTS page
↑ ^13.0 ^13.1 Lanza, F et al. (1991) cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins. J. Biol. Chem. 266 10638-45 PubMed GONUTS page
↑ Higginbottom, A et al. (2003) Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion. Biochem. Biophys. Res. Commun. 311 208-14 PubMed GONUTS page
↑ Masellis-Smith, A & Shaw, AR (1994) CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin. J. Immunol. 152 2768-77 PubMed GONUTS page
↑ Ikeyama, S et al. (1993) Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J. Exp. Med. 177 1231-7 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Boucheix, C et al. (1991) Molecular cloning of the CD9 antigen. A new family of cell surface proteins. J. Biol. Chem. 266 117-22 PubMed GONUTS page

[PMID:12796480-1] Takeda, Y et al. (2003) Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J. Cell Biol. 161 945-56 PubMed GONUTS page

[PMID:27993971-2] Yu, J et al. (2017) The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3. Biochem. J. 474 589-596 PubMed GONUTS page

[PMID:18541721-3] Nakazawa, Y et al. (2008) Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis. Blood 112 1730-9 PubMed GONUTS page

[PMID:15908444-4] Caby, MP et al. (2005) Exosomal-like vesicles are present in human blood plasma. Int. Immunol. 17 879-87 PubMed GONUTS page

[PMID:23533145-5] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:24769233-6] Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page

[PMID:21423176-7] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:19199708-8] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-9] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:15326289-10] Pisitkun, T et al. (2004) Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U.S.A. 101 13368-73 PubMed GONUTS page

[PMID:16502470-11] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:6198179-12] Katz, F et al. (1983) Chromosome assignment of monoclonal antibody-defined determinants on human leukemic cells. Eur. J. Immunol. 13 1008-13 PubMed GONUTS page

[PMID:2037603-13] 13.0 ^13.1 Lanza, F et al. (1991) cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins. J. Biol. Chem. 266 10638-45 PubMed GONUTS page

[PMID:14575715-14] Higginbottom, A et al. (2003) Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion. Biochem. Biophys. Res. Commun. 311 208-14 PubMed GONUTS page

[PMID:7511626-15] Masellis-Smith, A & Shaw, AR (1994) CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin. J. Immunol. 152 2768-77 PubMed GONUTS page

[PMID:8478605-16] Ikeyama, S et al. (1993) Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J. Exp. Med. 177 1231-7 PubMed GONUTS page

[PMID:21873635-17] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1840589-18] Boucheix, C et al. (1991) Molecular cloning of the CD9 antigen. A new family of cell surface proteins. J. Biol. Chem. 266 117-22 PubMed GONUTS page

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HUMAN:CD9

Contents

Annotations

Notes

References

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