HUMAN:CD177

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CD177 (synonyms: NB1, PRV1)
Protein Name(s)	CD177 antigen Human neutrophil alloantigen 2a HNA-2a NB1 glycoprotein NB1 GP Polycythemia rubra vera protein 1 PRV-1
External Links
UniProt	Q8N6Q3
EMBL	AF146747 AJ290452 AJ305326 AJ310433 AY358932 BT020111 BC029167
CCDS	CCDS62700.1
RefSeq	NP_065139.2
UniGene	Hs.232165
ProteinModelPortal	Q8N6Q3
SMR	Q8N6Q3
BioGrid	121389
IntAct	Q8N6Q3
MINT	MINT-1453771
STRING	9606.ENSP00000388794
DMDM	91208246
PaxDb	Q8N6Q3
PRIDE	Q8N6Q3
DNASU	57126
Ensembl	ENST00000378012
GeneID	57126
KEGG	hsa:57126
UCSC	uc002owi.3 uc021uvf.1
CTD	57126
GeneCards	GC19P043857
H-InvDB	HIX0017865
HGNC	HGNC:30072
MIM	162860
neXtProt	NX_Q8N6Q3
PharmGKB	PA142672147
eggNOG	NOG75007
GeneTree	ENSGT00530000063351
HOVERGEN	HBG081064
InParanoid	Q8N6Q3
KO	K06552
PhylomeDB	Q8N6Q3
Reactome	REACT_12051
GeneWiki	CD177
GenomeRNAi	57126
NextBio	63021
PRO	PR:Q8N6Q3
Proteomes	UP000005640
Bgee	Q8N6Q3
CleanEx	HS_CD177
Genevestigator	Q8N6Q3
GO	GO:0031225 GO:0070062 GO:0005886 GO:0007596 GO:0050900
InterPro	IPR001526
Pfam	PF00021

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0072672	neutrophil extravasation	PMID:22266279^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22266279^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:28240246^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P24158	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:28240246^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|involved_in	GO:1990266	neutrophil migration	PMID:28240246^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030100	regulation of endocytosis	PMID:28807980^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P31997)\|has_regulation_target:(UniProtKB:P05107)	Seeded From UniProt	complete
involved_in	GO:2001044	regulation of integrin-mediated signaling pathway	PMID:28807980^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:28807980^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05107	F		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	PMID:18462208^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070821	tertiary granule membrane	PMID:18462208^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	PMID:18462208^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P24158)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18462208^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:17244676^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P24158	F	occurs_at:(GO:0005886)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17244676^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12675722^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:28807980^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:24926686^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23461681^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045217	cell-cell junction maintenance	PMID:23202369^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0072672) occurs_in:(CL:0000071)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:27227454^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043315	positive regulation of neutrophil degranulation	PMID:21193407^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05107,UniProtKB:P11215	P		Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	PMID:21193407^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05107,UniProtKB:P11215	P	occurs_in:(CL:0000096)	Seeded From UniProt	complete
part_of	GO:0044853	plasma membrane raft	PMID:21193407^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:21193407^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05107,UniProtKB:P11215	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21193407^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	PMID:17580308^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072672	neutrophil extravasation	PMID:17580308^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007159	leukocyte cell-cell adhesion	PMID:17580308^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:17580308^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16284	F		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	PMID:17244676^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P24158)	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:28807980^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990266	neutrophil migration	PMID:28807980^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070821	tertiary granule membrane	Reactome:R-HSA-6798747	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	Reactome:R-HSA-202733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035579	specific granule membrane	Reactome:R-HSA-6799350	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-140875	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6799350 Reactome:R-HSA-6798747 Reactome:R-HSA-5607004 Reactome:R-HSA-202702	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kuckleburg, CJ et al. (2012) Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils. J. Immunol. 188 2419-26 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Jerke, U et al. (2017) Characterization of the CD177 interaction with the ANCA antigen proteinase 3. Sci Rep 7 43328 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Bai, M et al. (2017) CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 130 2092-2100 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 von Vietinghoff, S et al. (2008) Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing. Clin. Exp. Immunol. 152 508-16 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 von Vietinghoff, S et al. (2007) NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils. Blood 109 4487-93 PubMed GONUTS page
↑ Caruccio, L et al. (2003) Expression of human neutrophil antigen-2a (NB1) is increased in pregnancy. Transfusion 43 357-63 PubMed GONUTS page
↑ Hu, N et al. (2014) Differential expression of granulopoiesis related genes in neutrophil subsets distinguished by membrane expression of CD177. PLoS ONE 9 e99671 PubMed GONUTS page
↑ Wang, L et al. (2013) Surface receptor CD177/NB1 does not confer a recruitment advantage to neutrophilic granulocytes during human peritonitis. Eur. J. Haematol. 90 436-7 PubMed GONUTS page
↑ Kuckleburg, CJ & Newman, PJ (2013) Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler. Thromb. Vasc. Biol. 33 275-84 PubMed GONUTS page
↑ Wu, Z et al. (2016) Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion. PLoS Genet. 12 e1006067 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Jerke, U et al. (2011) Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation. J. Biol. Chem. 286 7070-81 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Sachs, UJ et al. (2007) The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J. Biol. Chem. 282 23603-12 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:22266279-1] 1.0 ^1.1 Kuckleburg, CJ et al. (2012) Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils. J. Immunol. 188 2419-26 PubMed GONUTS page

[PMID:28240246-2] 2.0 ^2.1 ^2.2 Jerke, U et al. (2017) Characterization of the CD177 interaction with the ANCA antigen proteinase 3. Sci Rep 7 43328 PubMed GONUTS page

[PMID:28807980-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Bai, M et al. (2017) CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 130 2092-2100 PubMed GONUTS page

[PMID:18462208-4] 4.0 ^4.1 ^4.2 ^4.3 von Vietinghoff, S et al. (2008) Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing. Clin. Exp. Immunol. 152 508-16 PubMed GONUTS page

[PMID:17244676-5] 5.0 ^5.1 ^5.2 von Vietinghoff, S et al. (2007) NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils. Blood 109 4487-93 PubMed GONUTS page

[PMID:12675722-6] Caruccio, L et al. (2003) Expression of human neutrophil antigen-2a (NB1) is increased in pregnancy. Transfusion 43 357-63 PubMed GONUTS page

[PMID:24926686-7] Hu, N et al. (2014) Differential expression of granulopoiesis related genes in neutrophil subsets distinguished by membrane expression of CD177. PLoS ONE 9 e99671 PubMed GONUTS page

[PMID:23461681-8] Wang, L et al. (2013) Surface receptor CD177/NB1 does not confer a recruitment advantage to neutrophilic granulocytes during human peritonitis. Eur. J. Haematol. 90 436-7 PubMed GONUTS page

[PMID:23202369-9] Kuckleburg, CJ & Newman, PJ (2013) Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler. Thromb. Vasc. Biol. 33 275-84 PubMed GONUTS page

[PMID:27227454-10] Wu, Z et al. (2016) Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion. PLoS Genet. 12 e1006067 PubMed GONUTS page

[PMID:21193407-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Jerke, U et al. (2011) Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation. J. Biol. Chem. 286 7070-81 PubMed GONUTS page

[PMID:17580308-12] 12.0 ^12.1 ^12.2 ^12.3 Sachs, UJ et al. (2007) The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J. Biol. Chem. 282 23603-12 PubMed GONUTS page

[PMID:23533145-13] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

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HUMAN:CD177

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