HUMAN:CCR5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CCR5 (synonyms: CMKBR5)
Protein Name(s)	C-C chemokine receptor type 5 C-C CKR-5 CC-CKR-5 CCR-5 CCR5 CHEMR13 HIV-1 fusion coreceptor
External Links
UniProt	P51681
EMBL	X91492 U54994 U57840 U83326 AF011500 AF011501 AF011502 AF011503 AF011505 AF011506 AF011507 AF011508 AF011509 AF011510 AF011511 AF011512 AF011513 AF011514 AF011515 AF011516 AF011517 AF011518 AF011519 AF011520 AF011521 AF011522 AF011523 AF011524 AF011525 AF011526 AF011527 AF011528 AF011529 AF011530 AF011531 AF011532 AF011533 AF011534 AF011535 AF011536 AF011537 AF031237 AF052539 AY221093 U95626 BC038398
CCDS	CCDS2739.1
PIR	A43113
RefSeq	NP_000570.1 NP_001093638.1
UniGene	Hs.450802
PDB	1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS
PDBsum	1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS
ProteinModelPortal	P51681
SMR	P51681
BioGrid	107639
DIP	DIP-5866N
IntAct	P51681
MINT	MINT-103024
BindingDB	P51681
ChEMBL	CHEMBL274
DrugBank	DB04835
GuidetoPHARMACOLOGY	62
PhosphoSite	P51681
DMDM	1705896
PaxDb	P51681
PRIDE	P51681
Ensembl	ENST00000292303 ENST00000445772
GeneID	1234
KEGG	hsa:1234
UCSC	uc003cpo.4
CTD	1234
GeneCards	GC03P046386
HGNC	HGNC:1606
MIM	601373 609423 610379 612522
neXtProt	NX_P51681
Orphanet	319269
PharmGKB	PA26170
eggNOG	NOG148353
HOVERGEN	HBG106917
InParanoid	P51681
KO	K04180
OMA	GNTMCQL
OrthoDB	EOG738051
PhylomeDB	P51681
TreeFam	TF330966
Reactome	REACT_15344 REACT_19231 REACT_6903
SignaLink	P51681
EvolutionaryTrace	P51681
GeneWiki	CCR5
GenomeRNAi	1234
NextBio	5035
PRO	PR:P51681
Proteomes	UP000005640
Bgee	P51681
ExpressionAtlas	P51681
Genevestigator	P51681
GO	GO:0009986 GO:0005737 GO:0005768 GO:0009897 GO:0005887 GO:0005886 GO:0003779 GO:0019957 GO:0016493 GO:0071791 GO:0004950 GO:0015026 GO:0004435 GO:0006816 GO:0019722 GO:0007166 GO:0007267 GO:0006968 GO:0071222 GO:0070098 GO:0006935 GO:0002407 GO:0030260 GO:0007186 GO:0006955 GO:0006954 GO:0000165 GO:0007204 GO:0014808 GO:0070723 GO:0023052 GO:0016032
InterPro	IPR002240 IPR000355 IPR000276 IPR017452
PANTHER	PTHR24227
Pfam	PF00001
PRINTS	PR00657 PR01110 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0009897	external side of plasma membrane	PMID:10383387^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016493	C-C chemokine receptor activity	PMID:10383387^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:10383387^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13236	F		Seeded From UniProt	complete
enables	GO:0071791	chemokine (C-C motif) ligand 5 binding	PMID:8699119^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13501	F		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:10679098^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0070723	response to cholesterol	PMID:19523456^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0023052	signaling	PMID:12032188^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:8699119^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10147	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:10679098^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13236	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:10679098^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10147	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:8699119^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P32246	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:8699119^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13236	F		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:19523456^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:10679098^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016493	C-C chemokine receptor activity	PMID:8639485^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:19523456^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:10521508^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:19523456^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:10679098^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:10679098^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:19523456^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:8699119^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:10679098^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:12421915^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:12032188^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0071791	chemokine (C-C motif) ligand 5 binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000659270 UniProtKB:P51681	F		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200797 UniProtKB:P51684	P		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104616 MGI:MGI:107182 MGI:MGI:1333797 MGI:MGI:1891697 PANTHER:PTN001200797 RGD:708446 UniProtKB:P32246 UniProtKB:P51677 UniProtKB:P51681 UniProtKB:P51684 UniProtKB:P61073	F		Seeded From UniProt	complete
enables	GO:0019956	chemokine binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200797 UniProtKB:P49682 ZFIN:ZDB-GENE-031116-61	F		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200797 RGD:621528 UniProtKB:P51681 UniProtKB:P51684 UniProtKB:P61073	P		Seeded From UniProt	complete
enables	GO:0016493	C-C chemokine receptor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:104616 MGI:MGI:104618 MGI:MGI:106185 MGI:MGI:107182 MGI:MGI:107824 MGI:MGI:1096320 MGI:MGI:1201402 MGI:MGI:1333797 MGI:MGI:1341902 MGI:MGI:1891697 PANTHER:PTN001200797 UniProtKB:P32246 UniProtKB:P51681 UniProtKB:P51684	F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:103567 MGI:MGI:106185 MGI:MGI:107182 MGI:MGI:107824 MGI:MGI:109563 MGI:MGI:1277207 MGI:MGI:1333797 PANTHER:PTN001200797 RGD:621528 RGD:708446 UniProtKB:P32246 UniProtKB:P51681	C		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096320 PANTHER:PTN001200797 RGD:1308562 RGD:2906 RGD:620596 RGD:621528 UniProtKB:P32246	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:106185 PANTHER:PTN001628461 UniProtKB:P32246	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104618 MGI:MGI:106185 MGI:MGI:1920904 PANTHER:PTN001628676 RGD:620596 RGD:620876 RGD:708446	P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:104616 MGI:MGI:107824 MGI:MGI:1096320 MGI:MGI:1201402 MGI:MGI:1333797 MGI:MGI:1341902 MGI:MGI:1346338 PANTHER:PTN001200797 UniProtKB:F1R6D3 UniProtKB:P25025 UniProtKB:P51684 ZFIN:ZDB-GENE-031116-61	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001628676 RGD:620596 UniProtKB:P41597	C		Seeded From UniProt	complete
enables	GO:0016493	C-C chemokine receptor activity	PMID:11278962^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:11278962^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004950	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016493	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016493	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016493	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004950	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016493	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016493	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016493	P		Seeded From UniProt	complete
involved_in	GO:2000110	negative regulation of macrophage apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51682 ensembl:ENSMUSP00000107069	P		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51682 ensembl:ENSMUSP00000107069	F		Seeded From UniProt	complete
enables	GO:0016493	C-C chemokine receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51682 ensembl:ENSMUSP00000107069	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51682 ensembl:ENSMUSP00000107069	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51682 ensembl:ENSMUSP00000107069	C		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51682 ensembl:ENSMUSP00000107069	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004950	chemokine receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000355	F		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000355 InterPro:IPR002240	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002240	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002240	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000355 InterPro:IPR002240	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000355 InterPro:IPR002240 InterPro:IPR017452	C		Seeded From UniProt	complete
enables	GO:0016493	C-C chemokine receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002240	F		Seeded From UniProt	complete
enables	GO:0015026	coreceptor activity	PMID:10469138^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:10201901^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:10393923^[13] Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:8639485^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006968	cellular defense response	PMID:10201901^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:8639485^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:8639485^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:10741397^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10393923^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10201901^[12] Reactome:R-HSA-8937654 Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-380073 Reactome:R-HSA-373061 Reactome:R-HSA-164524 Reactome:R-HSA-164521 Reactome:R-HSA-164515 Reactome:R-HSA-164508 Reactome:R-HSA-164507 Reactome:R-HSA-164500	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10415069^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004950	chemokine receptor activity	PMID:10201901^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	PMID:8663314^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002407	dendritic cell chemotaxis	PMID:16621978^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030260	entry into host cell	Reactome:R-HSA-173107	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6783783	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019064	fusion of virus membrane with host plasma membrane	Reactome:R-HSA-164524	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0001618	virus receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1183	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Blanpain, C et al. (1999) Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity. J. Biol. Chem. 274 18902-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Combadiere, C et al. (1996) Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. J. Leukoc. Biol. 60 147-52 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Franchin, G et al. (2000) Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5. J. Immunol. 164 2592-601 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Cardaba, CM & Mueller, A (2009) Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells. Biochem. Pharmacol. 78 974-82 PubMed GONUTS page
↑ ^5.0 ^5.1 Sakai, N et al. (2002) p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis. Nephrol. Dial. Transplant. 17 998-1004 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Samson, M et al. (1996) Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35 3362-7 PubMed GONUTS page
↑ Orsini, MJ et al. (1999) Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J. Biol. Chem. 274 31076-86 PubMed GONUTS page
↑ Rey, M et al. (2002) Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes. J. Immunol. 169 5410-4 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 Govaerts, C et al. (2001) The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation. J. Biol. Chem. 276 13217-25 PubMed GONUTS page
↑ Efremov, R et al. (1999) Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function. Eur. J. Biochem. 263 746-56 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Rabin, RL et al. (1999) Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling. J. Immunol. 162 3840-50 PubMed GONUTS page
↑ ^13.0 ^13.1 Ling, K et al. (1999) Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors. Proc. Natl. Acad. Sci. U.S.A. 96 7922-7 PubMed GONUTS page
↑ Agace, WW et al. (2000) Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation. Eur. J. Immunol. 30 819-26 PubMed GONUTS page
↑ Klein, RS et al. (1999) Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. J. Immunol. 163 1636-46 PubMed GONUTS page
↑ Raport, CJ et al. (1996) Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha. J. Biol. Chem. 271 17161-6 PubMed GONUTS page
↑ Sánchez-Sánchez, N et al. (2006) The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J. Immunol. 176 5153-9 PubMed GONUTS page

[PMID:10383387-1] 1.0 ^1.1 ^1.2 Blanpain, C et al. (1999) Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity. J. Biol. Chem. 274 18902-8 PubMed GONUTS page

[PMID:8699119-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Combadiere, C et al. (1996) Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. J. Leukoc. Biol. 60 147-52 PubMed GONUTS page

[PMID:10679098-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Franchin, G et al. (2000) Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5. J. Immunol. 164 2592-601 PubMed GONUTS page

[PMID:19523456-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Cardaba, CM & Mueller, A (2009) Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells. Biochem. Pharmacol. 78 974-82 PubMed GONUTS page

[PMID:12032188-5] 5.0 ^5.1 Sakai, N et al. (2002) p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis. Nephrol. Dial. Transplant. 17 998-1004 PubMed GONUTS page

[PMID:8639485-6] 6.0 ^6.1 ^6.2 ^6.3 Samson, M et al. (1996) Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35 3362-7 PubMed GONUTS page

[PMID:10521508-7] Orsini, MJ et al. (1999) Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J. Biol. Chem. 274 31076-86 PubMed GONUTS page

[PMID:12421915-8] Rey, M et al. (2002) Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes. J. Immunol. 169 5410-4 PubMed GONUTS page

[PMID:21873635-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11278962-10] 10.0 ^10.1 Govaerts, C et al. (2001) The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation. J. Biol. Chem. 276 13217-25 PubMed GONUTS page

[PMID:10469138-11] Efremov, R et al. (1999) Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function. Eur. J. Biochem. 263 746-56 PubMed GONUTS page

[PMID:10201901-12] 12.0 ^12.1 ^12.2 ^12.3 Rabin, RL et al. (1999) Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling. J. Immunol. 162 3840-50 PubMed GONUTS page

[PMID:10393923-13] 13.0 ^13.1 Ling, K et al. (1999) Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors. Proc. Natl. Acad. Sci. U.S.A. 96 7922-7 PubMed GONUTS page

[PMID:10741397-14] Agace, WW et al. (2000) Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation. Eur. J. Immunol. 30 819-26 PubMed GONUTS page

[PMID:10415069-15] Klein, RS et al. (1999) Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. J. Immunol. 163 1636-46 PubMed GONUTS page

[PMID:8663314-16] Raport, CJ et al. (1996) Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha. J. Biol. Chem. 271 17161-6 PubMed GONUTS page

[PMID:16621978-17] Sánchez-Sánchez, N et al. (2006) The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J. Immunol. 176 5153-9 PubMed GONUTS page

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HUMAN:CCR5

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