HUMAN:CCR1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CCR1 (synonyms: CMKBR1, CMKR1, SCYAR1)
Protein Name(s)	C-C chemokine receptor type 1 C-C CKR-1 CC-CKR-1 CCR-1 CCR1 HM145 LD78 receptor Macrophage inflammatory protein 1-alpha receptor MIP-1alpha-R RANTES-R
External Links
UniProt	P32246
EMBL	L09230 L10918 D10925 BC051306 BC064991
CCDS	CCDS2737.1
PIR	A45177
RefSeq	NP_001286.1
UniGene	Hs.301921
PDB	1Y5D
PDBsum	1Y5D
ProteinModelPortal	P32246
SMR	P32246
BioGrid	107635
DIP	DIP-5832N
IntAct	P32246
MINT	MINT-140567
STRING	9606.ENSP00000296140
BindingDB	P32246
ChEMBL	CHEMBL2413
GuidetoPHARMACOLOGY	58
PhosphoSite	P32246
DMDM	416802
PaxDb	P32246
PRIDE	P32246
DNASU	1230
Ensembl	ENST00000296140
GeneID	1230
KEGG	hsa:1230
UCSC	uc003cph.1
CTD	1230
GeneCards	GC03M046218
HGNC	HGNC:1602
MIM	601159
neXtProt	NX_P32246
PharmGKB	PA26166
eggNOG	NOG148353
HOGENOM	HOG000234122
HOVERGEN	HBG106917
InParanoid	P32246
KO	K04176
OMA	FWIDYKL
OrthoDB	EOG738051
PhylomeDB	P32246
TreeFam	TF330966
Reactome	REACT_15344 REACT_19231
GeneWiki	CCR1
GenomeRNAi	1230
NextBio	5015
PRO	PR:P32246
Proteomes	UP000005640
Bgee	P32246
CleanEx	HS_CCR1
ExpressionAtlas	P32246
Genevestigator	P32246
GO	GO:0009897 GO:0005887 GO:0005886 GO:0019957 GO:0016493 GO:0071791 GO:0035717 GO:0004950 GO:0004435 GO:0006816 GO:0007155 GO:0007166 GO:0007267 GO:0006874 GO:0070098 GO:0006935 GO:0019221 GO:0002407 GO:0006887 GO:0007187 GO:0006955 GO:0006954 GO:0008152 GO:0030502 GO:0010629 GO:0051928 GO:0007204 GO:0070374 GO:0090026 GO:0045672 GO:0009611
InterPro	IPR002236 IPR000355 IPR000276 IPR017452
PANTHER	PTHR24227
Pfam	PF00001
PRINTS	PR00657 PR01106 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030335	positive regulation of cell migration	PMID:24056371^[1]	ECO:0000315			P		Figure 1	complete CACAO 8671
involved_in	GO:0030335	positive regulation of cell migration	PMID:24056371^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090026	positive regulation of monocyte chemotaxis	PMID:18587271^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0071791	chemokine (C-C motif) ligand 5 binding	PMID:10660125^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13501	F		Seeded From UniProt	complete
enables	GO:0071791	chemokine (C-C motif) ligand 5 binding	PMID:10734056^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13501	F		Seeded From UniProt	complete
enables	GO:0071791	chemokine (C-C motif) ligand 5 binding	PMID:7545673^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13501	F		Seeded From UniProt	complete
enables	GO:0071791	chemokine (C-C motif) ligand 5 binding	PMID:8699119^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13501	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21403648^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000062)	Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	PMID:21403648^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	PMID:15764707^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	PMID:21403648^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035717	chemokine (C-C motif) ligand 7 binding	PMID:10660125^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P80098	F		Seeded From UniProt	complete
enables	GO:0035717	chemokine (C-C motif) ligand 7 binding	PMID:7545673^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P80098	F		Seeded From UniProt	complete
involved_in	GO:0030502	negative regulation of bone mineralization	PMID:21403648^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000062)	Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:10660125^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10147	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:10660125^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55773	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:15764707^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10147	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:8699119^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13236	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:8699119^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10147	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:7545673^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10147	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:7545673^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13236	F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:15474493^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016493	C-C chemokine receptor activity	PMID:10734056^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:21403648^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000062) has_regulation_target:(UniProtKB:P02818)\|has_regulation_target:(UniProtKB:Q8TDD2)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:10706735^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000775)\|part_of:(CL:0000094)	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:10734056^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:10734056^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:10734056^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:15474493^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	PMID:10734056^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:10734056^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:10734056^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15001559^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18587271^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10660125^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000576)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15474493^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004950	chemokine receptor activity	PMID:10660125^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	PMID:10734056^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0071791	chemokine (C-C motif) ligand 5 binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200786 UniProtKB:P32246	F		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200797 UniProtKB:P51684	P		Seeded From UniProt	complete
enables	GO:0035717	chemokine (C-C motif) ligand 7 binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200786 UniProtKB:P32246	F		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104616 MGI:MGI:107182 MGI:MGI:1333797 MGI:MGI:1891697 PANTHER:PTN001200797 RGD:708446 UniProtKB:P32246 UniProtKB:P51677 UniProtKB:P51681 UniProtKB:P51684 UniProtKB:P61073	F		Seeded From UniProt	complete
enables	GO:0019956	chemokine binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200797 UniProtKB:P49682 ZFIN:ZDB-GENE-031116-61	F		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200797 RGD:621528 UniProtKB:P51681 UniProtKB:P51684 UniProtKB:P61073	P		Seeded From UniProt	complete
enables	GO:0016493	C-C chemokine receptor activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:104616 MGI:MGI:104618 MGI:MGI:106185 MGI:MGI:107182 MGI:MGI:107824 MGI:MGI:1096320 MGI:MGI:1201402 MGI:MGI:1333797 MGI:MGI:1341902 MGI:MGI:1891697 PANTHER:PTN001200797 UniProtKB:P32246 UniProtKB:P51681 UniProtKB:P51684	F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:103567 MGI:MGI:106185 MGI:MGI:107182 MGI:MGI:107824 MGI:MGI:109563 MGI:MGI:1277207 MGI:MGI:1333797 PANTHER:PTN001200797 RGD:621528 RGD:708446 UniProtKB:P32246 UniProtKB:P51681	C		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096320 PANTHER:PTN001200797 RGD:1308562 RGD:2906 RGD:620596 RGD:621528 UniProtKB:P32246	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:106185 PANTHER:PTN001628461 UniProtKB:P32246	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104618 MGI:MGI:106185 MGI:MGI:1920904 PANTHER:PTN001628676 RGD:620596 RGD:620876 RGD:708446	P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:104616 MGI:MGI:107824 MGI:MGI:1096320 MGI:MGI:1201402 MGI:MGI:1333797 MGI:MGI:1341902 MGI:MGI:1346338 PANTHER:PTN001200797 UniProtKB:F1R6D3 UniProtKB:P25025 UniProtKB:P51684 ZFIN:ZDB-GENE-031116-61	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001628676 RGD:620596 UniProtKB:P41597	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004950	chemokine receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000355	F		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000355	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002236 InterPro:IPR034321	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002236	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000355 InterPro:IPR002236	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000355 InterPro:IPR002236 InterPro:IPR017452 InterPro:IPR034321	C		Seeded From UniProt	complete
enables	GO:0016493	C-C chemokine receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002236 InterPro:IPR034321	F		Seeded From UniProt	complete
involved_in	GO:0090026	positive regulation of monocyte chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002236	P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:7505609^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:7505609^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:10770925^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:10910894^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:7683036^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7505609^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:7505609^[13] Reactome:R-HSA-8937654 Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-380073 Reactome:R-HSA-373073	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004950	chemokine receptor activity	PMID:10770925^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002407	dendritic cell chemotaxis	PMID:16621978^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6783783	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gilliland, CT et al. (2013) The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization. J. Biol. Chem. 288 32194-210 PubMed GONUTS page
↑ ^2.0 ^2.1 Sung, HJ et al. (2008) Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. Exp. Mol. Med. 40 332-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Berkhout, TA et al. (2000) Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1). Biochem. Pharmacol. 59 591-6 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Richardson, RM et al. (2000) Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2. J. Biol. Chem. 275 9201-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ben-Baruch, A et al. (1995) Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3. J. Biol. Chem. 270 22123-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Combadiere, C et al. (1996) Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. J. Leukoc. Biol. 60 147-52 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Vallet, S et al. (2011) A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function. Leukemia 25 1174-81 PubMed GONUTS page
↑ ^8.0 ^8.1 Zhang, N et al. (2005) A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc. Natl. Acad. Sci. U.S.A. 102 4536-41 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Lee, SM et al. (2004) PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells. Biochem. Biophys. Res. Commun. 324 768-72 PubMed GONUTS page
↑ Lee, SC et al. (2000) Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes. J. Immunol. 164 3392-401 PubMed GONUTS page
↑ Ko, J et al. (2004) Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. FASEB J. 18 890-2 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Nomura, H et al. (1993) Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. Int. Immunol. 5 1239-49 PubMed GONUTS page
↑ ^14.0 ^14.1 Mirzadegan, T et al. (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J. Biol. Chem. 275 25562-71 PubMed GONUTS page
↑ Howard, OM et al. (2000) LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. Blood 96 840-5 PubMed GONUTS page
↑ Gao, JL et al. (1993) Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. J. Exp. Med. 177 1421-7 PubMed GONUTS page
↑ Sánchez-Sánchez, N et al. (2006) The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J. Immunol. 176 5153-9 PubMed GONUTS page

[PMID:24056371-1] 1.0 ^1.1 Gilliland, CT et al. (2013) The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization. J. Biol. Chem. 288 32194-210 PubMed GONUTS page

[PMID:18587271-2] 2.0 ^2.1 Sung, HJ et al. (2008) Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. Exp. Mol. Med. 40 332-8 PubMed GONUTS page

[PMID:10660125-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Berkhout, TA et al. (2000) Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1). Biochem. Pharmacol. 59 591-6 PubMed GONUTS page

[PMID:10734056-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Richardson, RM et al. (2000) Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2. J. Biol. Chem. 275 9201-8 PubMed GONUTS page

[PMID:7545673-5] 5.0 ^5.1 ^5.2 ^5.3 Ben-Baruch, A et al. (1995) Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3. J. Biol. Chem. 270 22123-8 PubMed GONUTS page

[PMID:8699119-6] 6.0 ^6.1 ^6.2 Combadiere, C et al. (1996) Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. J. Leukoc. Biol. 60 147-52 PubMed GONUTS page

[PMID:21403648-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Vallet, S et al. (2011) A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function. Leukemia 25 1174-81 PubMed GONUTS page

[PMID:15764707-8] 8.0 ^8.1 Zhang, N et al. (2005) A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc. Natl. Acad. Sci. U.S.A. 102 4536-41 PubMed GONUTS page

[PMID:15474493-9] 9.0 ^9.1 ^9.2 Lee, SM et al. (2004) PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells. Biochem. Biophys. Res. Commun. 324 768-72 PubMed GONUTS page

[PMID:10706735-10] Lee, SC et al. (2000) Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes. J. Immunol. 164 3392-401 PubMed GONUTS page

[PMID:15001559-11] Ko, J et al. (2004) Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. FASEB J. 18 890-2 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7505609-13] 13.0 ^13.1 ^13.2 ^13.3 Nomura, H et al. (1993) Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. Int. Immunol. 5 1239-49 PubMed GONUTS page

[PMID:10770925-14] 14.0 ^14.1 Mirzadegan, T et al. (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J. Biol. Chem. 275 25562-71 PubMed GONUTS page

[PMID:10910894-15] Howard, OM et al. (2000) LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. Blood 96 840-5 PubMed GONUTS page

[PMID:7683036-16] Gao, JL et al. (1993) Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. J. Exp. Med. 177 1421-7 PubMed GONUTS page

[PMID:16621978-17] Sánchez-Sánchez, N et al. (2006) The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J. Immunol. 176 5153-9 PubMed GONUTS page

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HUMAN:CCR1

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