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HUMAN:CCNK

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CCNK (synonyms: CPR4)
Protein Name(s) Cyclin-K
External Links
UniProt O75909
EMBL AF060515
BT006950
AF542236
AL110504
BC015935
AH009612
BX247958
AB209373
CCDS CCDS45160.1
RefSeq NP_001092872.1
XP_005268211.1
UniGene Hs.510409
PDB 2I53
4CXA
4NST
4UN0
PDBsum 2I53
4CXA
4NST
4UN0
ProteinModelPortal O75909
SMR O75909
BioGrid 114339
IntAct O75909
MINT MINT-1437641
STRING 9606.ENSP00000374529
BindingDB O75909
ChEMBL CHEMBL3038475
PhosphoSite O75909
MaxQB O75909
PaxDb O75909
PRIDE O75909
DNASU 8812
Ensembl ENST00000389879
GeneID 8812
KEGG hsa:8812
UCSC uc001ygi.4
CTD 8812
GeneCards GC14P099947
HGNC HGNC:1596
HPA HPA000645
MIM 603544
neXtProt NX_O75909
PharmGKB PA26161
eggNOG COG5333
GeneTree ENSGT00760000119191
HOGENOM HOG000220828
HOVERGEN HBG050836
InParanoid O75909
OMA KIETSHP
OrthoDB EOG7VQJCR
TreeFam TF101010
SignaLink O75909
ChiTaRS CCNK
EvolutionaryTrace O75909
GeneWiki Cyclin_K
GenomeRNAi 8812
NextBio 33052
PRO PR:O75909
Proteomes UP000005640
Bgee O75909
CleanEx HS_CCNK
ExpressionAtlas O75909
Genevestigator O75909
GO GO:0002944
GO:0002945
GO:0005634
GO:0004693
GO:0019901
GO:0008353
GO:0006974
GO:0001701
GO:0007067
GO:0071157
GO:0006468
GO:0000079
GO:0006355
GO:0006366
Gene3D 1.10.472.10
InterPro IPR013763
IPR015429
IPR006671
PANTHER PTHR10026
Pfam PF00134
SMART SM00385
SUPFAM SSF47954

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:2001165

positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

PMID:22988298[1]

ECO:0000315

P

Figure 4

complete
CACAO 10238

involved_in

GO:0044828

negative regulation by host of viral genome replication

PMID:21555514[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001165

positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

PMID:22988298[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0061575

cyclin-dependent protein serine/threonine kinase activator activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000002653
PomBase:SPBC530.13

F

Seeded From UniProt

complete

involved_in

GO:0032786

positive regulation of DNA-templated transcription, elongation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000002653
SGD:S000003543

P

Seeded From UniProt

complete

enables

GO:0016538

cyclin-dependent protein serine/threonine kinase regulator activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004597
PANTHER:PTN000002458
PomBase:SPBC530.13
PomBase:SPBP16F5.02
SGD:S000004216
SGD:S000004970
SGD:S000006229
UniProtKB:C9K506

F

Seeded From UniProt

complete

part_of

GO:0008024

cyclin/CDK positive transcription elongation factor complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025455
PANTHER:PTN000002653
PomBase:SPBC530.13
SGD:S000003543
UniProtKB:O60563
UniProtKB:O60583

C

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004597
PANTHER:PTN000002458
PomBase:SPBC32F12.06
PomBase:SPBC530.13
PomBase:SPBP16F5.02
SGD:S000004216
SGD:S000004970
SGD:S000006229
UniProtKB:O60563
UniProtKB:O60583
UniProtKB:O75909
UniProtKB:P51946
WB:WBGene00000508
WB:WBGene00009650

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025455
MGI:MGI:1328363
MGI:MGI:1913921
MGI:MGI:1921539
PANTHER:PTN000002458
PomBase:SPBC530.13
PomBase:SPBP16F5.02
RGD:70905
SGD:S000003543
TAIR:locus:2143671
TAIR:locus:2196919
UniProtKB:O60563
UniProtKB:O60583
UniProtKB:Q5B399
UniProtKB:Q96S94
UniProtKB:Q9UK58

C

Seeded From UniProt

complete

involved_in

GO:0071157

negative regulation of cell cycle arrest

PMID:9632813[4]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000000038

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:22012619[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14004

F

Seeded From UniProt

complete

enables

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

PMID:9632813[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:22012619[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

PMID:9632813[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0002945

cyclin K-CDK13 complex

PMID:22012619[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14004

C

Seeded From UniProt

complete

part_of

GO:0002944

cyclin K-CDK12 complex

PMID:22012619[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NYV4

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008353

P

Seeded From UniProt

complete

involved_in

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0061575

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004367

C

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

PMID:9632813[4]
Reactome:R-HSA-73857

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:9632813[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

Reactome:R-HSA-2173796

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042795

snRNA transcription by RNA polymerase II

Reactome:R-HSA-6807505

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

Reactome:R-HSA-75955
Reactome:R-HSA-112382

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6814885
Reactome:R-HSA-6814559
Reactome:R-HSA-6814555
Reactome:R-HSA-6814549
Reactome:R-HSA-6810238
Reactome:R-HSA-6810235
Reactome:R-HSA-6810234
Reactome:R-HSA-6810233
Reactome:R-HSA-6797616
Reactome:R-HSA-6797606
Reactome:R-HSA-6797100
Reactome:R-HSA-6797090
Reactome:R-HSA-6796647
Reactome:R-HSA-2176475
Reactome:R-HSA-113429
Reactome:R-HSA-113414
Reactome:R-HSA-113413
Reactome:R-HSA-113412
Reactome:R-HSA-113411
Reactome:R-HSA-112430
Reactome:R-HSA-112396
Reactome:R-HSA-112395
Reactome:R-HSA-112392
Reactome:R-HSA-112385
Reactome:R-HSA-112381
Reactome:R-HSA-112379

ECO:0000304

author statement supported by traceable reference used in manual assertion


























C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0044828

negative regulation by host of viral genome replication

PMID:21555514[2]

ECO:0000314

P

Figure 2B shows that Cyclin K inhibits HIV-1 gene replication in the presence of Nef.

complete
CACAO 10250

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Cheng, SW et al. (2012) Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II. Mol. Cell. Biol. 32 4691-704 PubMed GONUTS page
  2. ↑ 2.0 2.1 Khan, SZ & Mitra, D (2011) Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner. J. Biol. Chem. 286 22943-54 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Edwards, MC et al. (1998) Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. Mol. Cell. Biol. 18 4291-300 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Blazek, D et al. (2011) The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 25 2158-72 PubMed GONUTS page
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