HUMAN:CCL25

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CCL25 (synonyms: SCYA25, TECK)
Protein Name(s)	C-C motif chemokine 25 Chemokine TECK Small-inducible cytokine A25 Thymus-expressed chemokine
External Links
UniProt	O15444
EMBL	U86358 AB046579 AK292662 AC008946 CH471139 BC130561 BC144463
CCDS	CCDS12194.1 CCDS56080.1
RefSeq	NP_001188288.1 NP_005615.2
UniGene	Hs.310511
ProteinModelPortal	O15444
SMR	O15444
BioGrid	112273
DIP	DIP-5883N
IntAct	O15444
MINT	MINT-106224
STRING	9606.ENSP00000375086
PhosphoSite	O15444
PaxDb	O15444
PRIDE	O15444
DNASU	6370
Ensembl	ENST00000253451 ENST00000390669
GeneID	6370
KEGG	hsa:6370
UCSC	uc002mjc.4 uc002mjd.3
CTD	6370
GeneCards	GC19P008117
H-InvDB	HIX0039931
HGNC	HGNC:10624
HPA	HPA055883
MIM	602565
neXtProt	NX_O15444
PharmGKB	PA35556
eggNOG	NOG39655
GeneTree	ENSGT00510000049257
HOGENOM	HOG000293281
HOVERGEN	HBG050832
InParanoid	O15444
KO	K13072
OMA	QGVFEDC
OrthoDB	EOG76MKB6
PhylomeDB	O15444
TreeFam	TF353160
Reactome	REACT_15344 REACT_19231
GenomeRNAi	6370
NextBio	24752
PRO	PR:O15444
Proteomes	UP000005640
Bgee	O15444
CleanEx	HS_CCL25
ExpressionAtlas	O15444
Genevestigator	O15444
GO	GO:0005576 GO:0005615 GO:0031735 GO:0008009 GO:0042379 GO:0005179 GO:0060326 GO:0007166 GO:0006935 GO:0007186 GO:0006955 GO:0006954 GO:0050900 GO:1903237 GO:0001954
InterPro	IPR001811
Pfam	PF00048
SMART	SM00199
SUPFAM	SSF54117

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:18308860^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	PMID:18308860^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:18308860^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	PMID:18308860^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903237	negative regulation of leukocyte tethering or rolling	PMID:18308860^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031735	CCR10 chemokine receptor binding	PMID:10706668^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042379	chemokine receptor binding	PMID:23341447^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98259 PANTHER:PTN000245709 RGD:3645 RGD:69069 UniProtKB:P10147 UniProtKB:P13500 UniProtKB:P13501	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98259 PANTHER:PTN000245709 RGD:3645 UniProtKB:P10147 UniProtKB:P13500 UniProtKB:P13501	P		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98259 PANTHER:PTN000245709 RGD:3645 UniProtKB:P10147 UniProtKB:P13500 UniProtKB:P13501	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000245709 UniProtKB:O00585 UniProtKB:P10147 UniProtKB:Q99731	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000245709 RGD:3645 UniProtKB:P13501 UniProtKB:Q9Y258	P		Seeded From UniProt	complete
involved_in	GO:0048247	lymphocyte chemotaxis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1097153 PANTHER:PTN000245709 RGD:3645 RGD:69069 UniProtKB:P10147	P		Seeded From UniProt	complete
enables	GO:0048020	CCR chemokine receptor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000245709 UniProtKB:Q99731	F		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346316 PANTHER:PTN000245709 UniProtKB:O00175 UniProtKB:P51671 UniProtKB:Q9Y258	P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1097153 PANTHER:PTN000245709 RGD:3645 RGD:3647 UniProtKB:P10147	P		Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104593 MGI:MGI:1097153 MGI:MGI:1099448 MGI:MGI:1346316 MGI:MGI:98260 PANTHER:PTN000245709 RGD:1303200 RGD:3644 RGD:3645 RGD:3646 RGD:3647 RGD:620441 RGD:620458 RGD:69069 UniProtKB:O00175 UniProtKB:O00585 UniProtKB:O15444 UniProtKB:P10147 UniProtKB:P13501 UniProtKB:P22362 UniProtKB:P47992 UniProtKB:P51671 UniProtKB:P55773 UniProtKB:P78423 UniProtKB:P80098 UniProtKB:Q99616 UniProtKB:Q99731 UniProtKB:Q9Y258	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000245709 UniProtKB:O00585 UniProtKB:O15444 UniProtKB:P13501	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108224 MGI:MGI:98262 PANTHER:PTN000245709 RGD:3645 RGD:3647 RGD:620441 RGD:69069 UniProtKB:P10147 UniProtKB:P13500 UniProtKB:P13501	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101878 MGI:MGI:104593 MGI:MGI:1306779 MGI:MGI:98259 MGI:MGI:98260 MGI:MGI:98261 MGI:MGI:98262 MGI:MGI:99512 PANTHER:PTN000245709 RGD:3644 RGD:3645 RGD:3646 RGD:69069 UniProtKB:P10147 UniProtKB:P22362 UniProtKB:Q9Y258	C		Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108224 PANTHER:PTN000245709 UniProtKB:P10147 UniProtKB:P13500 UniProtKB:Q9Y258	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001811 InterPro:IPR036048	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001811 InterPro:IPR036048	P		Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001811 InterPro:IPR036048 InterPro:IPR039809	F		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:12949249^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:12949249^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:12949249^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	PMID:10640743^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:10544196^[7] Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:10640743^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:10640743^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:10640743^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:9285413^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-443978 Reactome:R-HSA-380073 Reactome:R-HSA-373074	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Miles, A et al. (2008) CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow. Am. J. Physiol. Gastrointest. Liver Physiol. 294 G1257-67 PubMed GONUTS page
↑ Gosling, J et al. (2000) Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J. Immunol. 164 2851-6 PubMed GONUTS page
↑ Watts, AO et al. (2013) β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. J. Biol. Chem. 288 7169-81 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Yang, D et al. (2003) Many chemokines including CCL20/MIP-3alpha display antimicrobial activity. J. Leukoc. Biol. 74 448-55 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Yu, CR et al. (2000) CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand. J. Immunol. 164 1293-305 PubMed GONUTS page
↑ Zabel, BA et al. (1999) Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. J. Exp. Med. 190 1241-56 PubMed GONUTS page
↑ Vicari, AP et al. (1997) TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity 7 291-301 PubMed GONUTS page

[PMID:18308860-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Miles, A et al. (2008) CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow. Am. J. Physiol. Gastrointest. Liver Physiol. 294 G1257-67 PubMed GONUTS page

[PMID:10706668-2] Gosling, J et al. (2000) Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J. Immunol. 164 2851-6 PubMed GONUTS page

[PMID:23341447-3] Watts, AO et al. (2013) β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. J. Biol. Chem. 288 7169-81 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12949249-5] 5.0 ^5.1 ^5.2 Yang, D et al. (2003) Many chemokines including CCL20/MIP-3alpha display antimicrobial activity. J. Leukoc. Biol. 74 448-55 PubMed GONUTS page

[PMID:10640743-6] 6.0 ^6.1 ^6.2 ^6.3 Yu, CR et al. (2000) CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand. J. Immunol. 164 1293-305 PubMed GONUTS page

[PMID:10544196-7] Zabel, BA et al. (1999) Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. J. Exp. Med. 190 1241-56 PubMed GONUTS page

[PMID:9285413-8] Vicari, AP et al. (1997) TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity 7 291-301 PubMed GONUTS page

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HUMAN:CCL25

Contents

Annotations

Notes

References

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