GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:CBPE

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CPE
Protein Name(s) Carboxypeptidase E

CPE Carboxypeptidase H CPH Enkephalin convertase Prohormone-processing carboxypeptidase

External Links
UniProt P16870
EMBL X51405
AB006898
AK090962
AK290996
AK294175
CH471056
CH471056
BC033866
BC053612
CCDS CCDS3810.1
PIR S09489
RefSeq NP_001864.1
UniGene Hs.75360
ProteinModelPortal P16870
SMR P16870
BioGrid 107755
IntAct P16870
MINT MINT-1374084
STRING 9606.ENSP00000386104
DrugBank DB00071
DB00030
MEROPS M14.005
PhosphoSite P16870
DMDM 115892
MaxQB P16870
PaxDb P16870
PRIDE P16870
DNASU 1363
Ensembl ENST00000402744
GeneID 1363
KEGG hsa:1363
UCSC uc003irg.4
CTD 1363
GeneCards GC04P166300
HGNC HGNC:2303
HPA CAB024907
HPA003819
MIM 114855
neXtProt NX_P16870
PharmGKB PA26824
eggNOG NOG322453
GeneTree ENSGT00760000119124
HOGENOM HOG000232185
HOVERGEN HBG003410
InParanoid P16870
KO K01294
OMA TLKTYWE
PhylomeDB P16870
TreeFam TF315592
Reactome REACT_15550
ChiTaRS CPE
GeneWiki Carboxypeptidase_E
GenomeRNAi 1363
NextBio 35471538
PRO PR:P16870
Proteomes UP000005640
Bgee P16870
CleanEx HS_CPE
ExpressionAtlas P16870
Genevestigator P16870
GO GO:0070062
GO:0005794
GO:0005634
GO:0005886
GO:0030667
GO:0030658
GO:0004180
GO:0050839
GO:0004181
GO:0042043
GO:0008270
GO:0003214
GO:0044267
GO:0006464
GO:0030070
GO:0008152
GO:0007218
GO:0072657
Gene3D 2.60.40.1120
InterPro IPR008969
IPR014766
IPR000834
Pfam PF00246
PRINTS PR00765
SMART SM00631
SUPFAM SSF49464
PROSITE PS00132
PS00133

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016055

Wnt receptor signaling pathway

PMID:22824791[1]

ECO:0000314

P

Figure 1.

complete
CACAO 5203

GO:0030877

beta-catenin destruction complex

PMID:22824791[1]

ECO:0000314

C

Figure 2.

complete
CACAO 5205

GO:0004175

endopeptidase activity

PMID:22824791[1]

ECO:0000314

F

Figure 3.

complete
CACAO 5207

involved_in

GO:0016055

Wnt signaling pathway

PMID:22824791[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0072657

protein localization to membrane

PMID:19166515[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050839

cell adhesion molecule binding

PMID:19166515[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UHC6

F

Seeded From UniProt

complete

enables

GO:0042043

neurexin family protein binding

PMID:19166515[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UHC6

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:19166515[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0003214

cardiac left ventricle morphogenesis

PMID:19593212[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:2334405[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006464

cellular protein modification process

PMID:2334405[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0097060

synaptic membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002264391
RGD:2394

C

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002264391
RGD:2394

C

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002264391
RGD:2394

C

Seeded From UniProt

complete

involved_in

GO:0030070

insulin processing

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101932
PANTHER:PTN002264391
RGD:2394

P

Seeded From UniProt

complete

involved_in

GO:0016485

protein processing

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000163972
RGD:2394
WB:WBGene00001189

P

Seeded From UniProt

complete

involved_in

GO:0006518

peptide metabolic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000163972
RGD:2394

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002264391
RGD:2394
UniProtKB:P16870

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1934569
PANTHER:PTN000163972
RGD:2394
RGD:70931

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1926006
MGI:MGI:1934569
PANTHER:PTN000163972
RGD:2394
RGD:70931

C

Seeded From UniProt

complete

enables

GO:0004181

metallocarboxypeptidase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004648
PANTHER:PTN000163972
RGD:2394
UniProtKB:Q9M9H7

F

Seeded From UniProt

complete

involved_in

GO:0033366

protein localization to secretory granule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00493
ensembl:ENSMUSP00000048555

P

Seeded From UniProt

complete

part_of

GO:0030667

secretory granule membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00493
ensembl:ENSMUSP00000048555

C

Seeded From UniProt

complete

involved_in

GO:0030072

peptide hormone secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00493
ensembl:ENSMUSP00000048555

P

Seeded From UniProt

complete

involved_in

GO:0030070

insulin processing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00493
ensembl:ENSMUSP00000048555

P

Seeded From UniProt

complete

enables

GO:0004180

carboxypeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00493
ensembl:ENSMUSP00000048555

F

Seeded From UniProt

complete

enables

GO:0004181

metallocarboxypeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000834

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000834

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000834

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:9019408[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004180

carboxypeptidase activity

PMID:9019408[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0008237

metallopeptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0482

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0004180

carboxypeptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0121

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0030133

transport vesicle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0244

C

Seeded From UniProt

complete

part_of

GO:0030658

transport vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0245

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Skalka, N et al. (2013) Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. Oncogene 32 2836-47 PubMed GONUTS page
  2. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Oiso, S et al. (2009) Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the CNS. J. Neurochem. 109 158-67 PubMed GONUTS page
  4. ↑ Arnett, DK et al. (2009) Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. J. Hypertens. 27 1585-93 PubMed GONUTS page
  5. ↑ 5.0 5.1 Manser, E et al. (1990) Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. Biochem. J. 267 517-25 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 Cool, DR et al. (1997) Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cell 88 73-83 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:CBPE&oldid=5954620"