HUMAN:CATA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CAT
Protein Name(s)	Catalase
External Links
UniProt	P04040
EMBL	X04085 X04086 X04087 X04088 X04089 X04090 X04091 X04092 X04093 X04094 X04095 X04096 X04076 AY028632 AK291585 AK315350 AY545477 AL035079 CH471064 CH471064 BC110398 BC112217 BC112219 L13609 K02400
CCDS	CCDS7891.1
PIR	A23646
RefSeq	NP_001743.1
UniGene	Hs.502302
PDB	1DGB 1DGF 1DGG 1DGH 1F4J 1QQW
PDBsum	1DGB 1DGF 1DGG 1DGH 1F4J 1QQW
ProteinModelPortal	P04040
SMR	P04040
BioGrid	107297
IntAct	P04040
MINT	MINT-1210583
STRING	9606.ENSP00000241052
DrugBank	DB01213
PeroxiBase	5282
PhosphoSite	P04040
DMDM	115702
OGP	P04040
REPRODUCTION-2DPAGE	IPI00465436 P04040
SWISS-2DPAGE	P04040
MaxQB	P04040
PaxDb	P04040
PeptideAtlas	P04040
PRIDE	P04040
DNASU	847
Ensembl	ENST00000241052
GeneID	847
KEGG	hsa:847
UCSC	uc001mvm.3
CTD	847
GeneCards	GC11P034460
H-InvDB	HIX0009550
HGNC	HGNC:1516
HPA	CAB001515 HPA055838
MIM	115500 614097
neXtProt	NX_P04040
Orphanet	926
PharmGKB	PA26099
eggNOG	COG0753
GeneTree	ENSGT00390000018100
HOVERGEN	HBG003986
InParanoid	P04040
KO	K03781
OMA	RNPRNFF
OrthoDB	EOG7V7660
PhylomeDB	P04040
TreeFam	TF300540
BioCyc	MetaCyc:MONOMER66-341
Reactome	REACT_172715 REACT_2086
SABIO-RK	P04040
ChiTaRS	CAT
EvolutionaryTrace	P04040
GeneWiki	Catalase
GenomeRNAi	847
NextBio	3550
PRO	PR:P04040
Proteomes	UP000005640
Bgee	P04040
CleanEx	HS_CAT
ExpressionAtlas	P04040
Genevestigator	P04040
GO	GO:0005829 GO:0005783 GO:0070062 GO:0005925 GO:0005794 GO:0043231 GO:0005764 GO:0016020 GO:0005758 GO:0005782 GO:0005778 GO:0005777 GO:0005886 GO:0004046 GO:0016209 GO:0004096 GO:0019899 GO:0020037 GO:0046872 GO:0050661 GO:0016684 GO:0042803 GO:0005102 GO:0009060 GO:0007568 GO:0071363 GO:0008203 GO:0020027 GO:0042744 GO:0043066 GO:0032088 GO:0055086 GO:0001649 GO:0051781 GO:0051092 GO:0014068 GO:0051289 GO:0051262 GO:0006144 GO:0006195 GO:0055093 GO:0001666 GO:0000302 GO:0033197 GO:0044281 GO:0006641 GO:0001657 GO:0009650
Gene3D	2.40.180.10
InterPro	IPR018028 IPR020835 IPR024708 IPR024711 IPR011614 IPR002226 IPR010582
PANTHER	PTHR11465
Pfam	PF00199 PF06628
PIRSF	PIRSF038928
PRINTS	PR00067
SMART	SM01060
SUPFAM	SSF56634
PROSITE	PS00437 PS00438 PS51402

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0070062	extracellular exosome	PMID:23533145^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16210410^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000134)\|part_of:(CL:0000062)	Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:16210410^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P	results_in_determination_of:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:21976670^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	PMID:11134921^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	PMID:10656833^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	PMID:10656833^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:16644728^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10656833^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:18379038^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:11134921^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:10656833^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16781659^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q08426	F		Seeded From UniProt	complete
enables	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24270	F		Seeded From UniProt	complete
enables	GO:0016209	antioxidant activity	PMID:10514471^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009650	UV protection	PMID:17053817^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009650	UV protection	PMID:16644728^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005778	peroxisomal membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24270	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:19479899^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:9053548^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002306)\|part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:2895531^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002306)	Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:18379038^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21976670^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P50542	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:20178365^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P50542	F		Seeded From UniProt	complete
enables	GO:0004096	catalase activity	PMID:18312938^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004096	catalase activity	PMID:18379038^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004096	catalase activity	PMID:16644728^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000302	response to reactive oxygen species	PMID:16644728^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88271 PANTHER:PTN000157250 PomBase:SPCC757.07c RGD:2279 SGD:S000002664 TAIR:locus:2034428 UniProtKB:O13289 UniProtKB:P04040 UniProtKB:P77872 UniProtKB:Q42547 dictyBase:DDB_G0274595	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000261 PANTHER:PTN000157250 TAIR:locus:2034428 UniProtKB:O13289 UniProtKB:Q59635	P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000157250 UniProtKB:P04040	F		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88271 PANTHER:PTN000157252 RGD:2279 UniProtKB:P04040 WB:WBGene00000831 dictyBase:DDB_G0274595	C		Seeded From UniProt	complete
enables	GO:0004096	catalase activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000261 MGI:MGI:88271 PANTHER:PTN000157250 PomBase:SPCC757.07c RGD:2279 SGD:S000002664 SGD:S000003320 UniProtKB:O13289 UniProtKB:O52762 UniProtKB:P00432 UniProtKB:P04040 UniProtKB:P12365 UniProtKB:P18122 UniProtKB:P18123 UniProtKB:P25819 UniProtKB:Q59337 UniProtKB:Q5B0L2 WB:WBGene00000830 WB:WBGene00000831 dictyBase:DDB_G0274595	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:29568061^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04040	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21988832^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04040	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004096	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004096	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004096	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016209	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004096	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004096	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004096	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004096	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004096	P		Seeded From UniProt	complete
involved_in	GO:0080184	response to phenylpropanoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0055093	response to hyperoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0033591	response to L-ascorbic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0033197	response to vitamin E	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0014854	response to inactivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0010193	response to ozone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0009642	response to light intensity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	C		Seeded From UniProt	complete
enables	GO:0004096	catalase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	F		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0000302	response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04762 ensembl:ENSRNOP00000011230	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	P		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	P		Seeded From UniProt	complete
involved_in	GO:0020027	hemoglobin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	P		Seeded From UniProt	complete
enables	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	F		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	P		Seeded From UniProt	complete
involved_in	GO:0009060	aerobic respiration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	P		Seeded From UniProt	complete
involved_in	GO:0006641	triglyceride metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	P		Seeded From UniProt	complete
part_of	GO:0005778	peroxisomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	C		Seeded From UniProt	complete
enables	GO:0004096	catalase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	F		Seeded From UniProt	complete
enables	GO:0004046	aminoacylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24270 ensembl:ENSMUSP00000028610	F		Seeded From UniProt	complete
enables	GO:0004096	catalase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011614 InterPro:IPR018028 InterPro:IPR024708 InterPro:IPR024711 InterPro:IPR037060 InterPro:IPR040333	F		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018028 InterPro:IPR024711 InterPro:IPR040333	P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002226 InterPro:IPR011614 InterPro:IPR018028 InterPro:IPR020835 InterPro:IPR024711 InterPro:IPR037060 InterPro:IPR040333	F		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040333	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011614 InterPro:IPR018028 InterPro:IPR020835 InterPro:IPR024711 InterPro:IPR037060	P		Seeded From UniProt	complete
enables	GO:0004096	catalase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.11.1.6	F		Seeded From UniProt	complete
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	Reactome:R-HSA-3299685	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006625	protein targeting to peroxisome	Reactome:R-HSA-9033241	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-9622814 Reactome:R-HSA-9033236 Reactome:R-HSA-9033235	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005782	peroxisomal matrix	Reactome:R-HSA-9033235 Reactome:R-HSA-76031	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6800434 Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0376	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0576 UniProtKB-SubCell:SL-0204	C		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0575	F		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^4.0 ^4.1 Foster, LJ et al. (2005) Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Stem Cells 23 1367-77 PubMed GONUTS page
↑ ^5.0 ^5.1 Freitas, MO et al. (2011) PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14. J. Biol. Chem. 286 40509-19 PubMed GONUTS page
↑ ^6.0 ^6.1 Safo, MK et al. (2001) Structure of tetragonal crystals of human erythrocyte catalase. Acta Crystallogr. D Biol. Crystallogr. 57 1-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Putnam, CD et al. (2000) Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism. J. Mol. Biol. 296 295-309 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Rezvani, HR et al. (2006) Protective effects of catalase overexpression on UVB-induced apoptosis in normal human keratinocytes. J. Biol. Chem. 281 17999-8007 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Hashimoto, F et al. (2008) Presence and some characteristics of peroxisomes in immortalized human trophoblast cells. Biol. Pharm. Bull. 31 546-52 PubMed GONUTS page
↑ Makkar, RS et al. (2006) Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix. Arch. Biochem. Biophys. 451 128-40 PubMed GONUTS page
↑ Yamashita, H et al. (1999) Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. J. Biol. Chem. 274 29897-904 PubMed GONUTS page
↑ Rezvani, HR et al. (2007) Protection of normal human reconstructed epidermis from UV by catalase overexpression. Cancer Gene Ther. 14 174-86 PubMed GONUTS page
↑ Toro, AA et al. (2009) Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts. J. Cell. Biochem. 107 1083-96 PubMed GONUTS page
↑ Espeel, M & Van Limbergen, G (1995) Immunocytochemical localization of peroxisomal proteins in human liver and kidney. J. Inherit. Metab. Dis. 18 Suppl 1 135-54 PubMed GONUTS page
↑ Litwin, JA et al. (1988) Immunocytochemical demonstration of peroxisomal enzymes in human kidney biopsies. Virchows Arch., B, Cell Pathol. 54 207-13 PubMed GONUTS page
↑ Ghosh, D & Berg, JM (2010) A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. J. Am. Chem. Soc. 132 3973-9 PubMed GONUTS page
↑ Pljesa-Ercegovac, M et al. () Altered antioxidant capacity in human renal cell carcinoma: role of glutathione associated enzymes. Urol. Oncol. 26 175-81 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Liu, X et al. (2018) An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nat Commun 9 1188 PubMed GONUTS page
↑ Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page

[PMID:23533145-1] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:21423176-2] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:16210410-4] 4.0 ^4.1 Foster, LJ et al. (2005) Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Stem Cells 23 1367-77 PubMed GONUTS page

[PMID:21976670-5] 5.0 ^5.1 Freitas, MO et al. (2011) PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14. J. Biol. Chem. 286 40509-19 PubMed GONUTS page

[PMID:11134921-6] 6.0 ^6.1 Safo, MK et al. (2001) Structure of tetragonal crystals of human erythrocyte catalase. Acta Crystallogr. D Biol. Crystallogr. 57 1-7 PubMed GONUTS page

[PMID:10656833-7] 7.0 ^7.1 ^7.2 ^7.3 Putnam, CD et al. (2000) Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism. J. Mol. Biol. 296 295-309 PubMed GONUTS page

[PMID:16644728-8] 8.0 ^8.1 ^8.2 ^8.3 Rezvani, HR et al. (2006) Protective effects of catalase overexpression on UVB-induced apoptosis in normal human keratinocytes. J. Biol. Chem. 281 17999-8007 PubMed GONUTS page

[PMID:18379038-9] 9.0 ^9.1 ^9.2 Hashimoto, F et al. (2008) Presence and some characteristics of peroxisomes in immortalized human trophoblast cells. Biol. Pharm. Bull. 31 546-52 PubMed GONUTS page

[PMID:16781659-10] Makkar, RS et al. (2006) Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix. Arch. Biochem. Biophys. 451 128-40 PubMed GONUTS page

[PMID:10514471-11] Yamashita, H et al. (1999) Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. J. Biol. Chem. 274 29897-904 PubMed GONUTS page

[PMID:17053817-12] Rezvani, HR et al. (2007) Protection of normal human reconstructed epidermis from UV by catalase overexpression. Cancer Gene Ther. 14 174-86 PubMed GONUTS page

[PMID:19479899-13] Toro, AA et al. (2009) Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts. J. Cell. Biochem. 107 1083-96 PubMed GONUTS page

[PMID:9053548-14] Espeel, M & Van Limbergen, G (1995) Immunocytochemical localization of peroxisomal proteins in human liver and kidney. J. Inherit. Metab. Dis. 18 Suppl 1 135-54 PubMed GONUTS page

[PMID:2895531-15] Litwin, JA et al. (1988) Immunocytochemical demonstration of peroxisomal enzymes in human kidney biopsies. Virchows Arch., B, Cell Pathol. 54 207-13 PubMed GONUTS page

[PMID:20178365-16] Ghosh, D & Berg, JM (2010) A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. J. Am. Chem. Soc. 132 3973-9 PubMed GONUTS page

[PMID:18312938-17] Pljesa-Ercegovac, M et al. () Altered antioxidant capacity in human renal cell carcinoma: role of glutathione associated enzymes. Urol. Oncol. 26 175-81 PubMed GONUTS page

[PMID:21873635-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:29568061-19] Liu, X et al. (2018) An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nat Commun 9 1188 PubMed GONUTS page

[PMID:21988832-20] Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page

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