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HUMAN:CAPR2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CAPRIN2 (ECO:0000312 with EMBL:AAI17673.1) (synonyms: C1QDC1, EEG1 (ECO:0000312 with EMBL:AAL71549.1), KIAA1873, RNG140) | |
| Protein Name(s) | Caprin-2
C1q domain-containing protein 1 Cytoplasmic activation/proliferation-associated protein 2 Gastric cancer multidrug resistance-associated protein Protein EEG-1 RNA granule protein 140 | |
| External Links | ||
| UniProt | Q6IMN6 | |
| EMBL | AY074490 AY074491 AC010198 BC066295 BC111007 BC117672 BC117673 AK021453 AK026222 AF326778 BX538080 BK001102 BK001103 BR000870 | |
| CCDS | CCDS41766.2 CCDS55816.1 CCDS8720.1 | |
| RefSeq | NP_001002259.1 NP_001193785.1 NP_076414.2 NP_115532.3 XP_006719200.1 XP_006719210.1 XP_006719211.1 | |
| UniGene | Hs.234355 | |
| PDB | 4OUL 4OUM | |
| PDBsum | 4OUL 4OUM | |
| ProteinModelPortal | Q6IMN6 | |
| SMR | Q6IMN6 | |
| BioGrid | 122431 | |
| IntAct | Q6IMN6 | |
| PhosphoSite | Q6IMN6 | |
| DMDM | 74748798 | |
| MaxQB | Q6IMN6 | |
| PaxDb | Q6IMN6 | |
| PRIDE | Q6IMN6 | |
| Ensembl | ENST00000298892 ENST00000395805 ENST00000417045 ENST00000454014 | |
| GeneID | 65981 | |
| KEGG | hsa:65981 | |
| UCSC | uc001rjf.1 uc001rjg.1 uc001rjh.1 uc001rjl.4 | |
| CTD | 65981 | |
| GeneCards | GC12M030862 | |
| HGNC | HGNC:21259 | |
| HPA | HPA039746 | |
| MIM | 610375 | |
| neXtProt | NX_Q6IMN6 | |
| PharmGKB | PA162381044 | |
| eggNOG | NOG41180 | |
| GeneTree | ENSGT00760000119052 | |
| HOGENOM | HOG000082543 | |
| HOVERGEN | HBG057777 | |
| InParanoid | Q6IMN6 | |
| OMA | NSRAGWS | |
| PhylomeDB | Q6IMN6 | |
| TreeFam | TF329471 | |
| SignaLink | Q6IMN6 | |
| ChiTaRS | CAPRIN2 | |
| GeneWiki | CAPRIN2 | |
| GenomeRNAi | 65981 | |
| NextBio | 67435 | |
| PRO | PR:Q6IMN6 | |
| Proteomes | UP000005640 | |
| Bgee | Q6IMN6 | |
| ExpressionAtlas | Q6IMN6 | |
| Genevestigator | Q6IMN6 | |
| GO | GO:0005813 GO:0005737 GO:0005739 GO:0005634 GO:0043235 GO:0005102 GO:0003723 GO:0030308 GO:0017148 GO:0090263 GO:0050775 GO:0061003 GO:0033138 GO:0032092 GO:0045944 | |
| Gene3D | 2.60.120.40 | |
| InterPro | IPR001073 IPR028816 IPR022070 IPR008983 | |
| PANTHER | PTHR22922 | |
| Pfam | PF00386 PF12287 | |
| PRINTS | PR00007 | |
| SMART | SM00110 | |
| SUPFAM | SSF49842 | |
| PROSITE | PS50871 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0030169 |
low-density lipoprotein binding |
ECO:0000021 |
|
F |
Figure 1A: Co-immunoprecipitation assay confirmed that caprin-2 interacts with LRP5 and not caprin-1 |
complete | ||||
| GO:0030169 |
low-density lipoprotein binding |
ECO:0000021 |
|
F |
Figure 1B: Co-immunoprecipitation showed that LRP6 was coimmunoprecipitated with Caprin-2. Caprin-2 interacts with LRP6. |
complete | ||||
| GO:0030177 |
positive regulation of Wnt receptor signaling pathway |
ECO:0000314 |
P |
Figure 2A: Capin-2 overexpression enhanced the accumulation of cytoplasmic beta catenin leading to the activation of Wnt signalling. |
complete | |||||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
ECO:0000315 |
P |
Figure 2C:Knockdown of caprin-2 decreased Wnt3a-stimulated LEF-1 dependent reporter activity and diminished Wnt induced accummulation of beta catenin. |
complete | |||||
| GO:0042327 |
positive regulation of phosphorylation |
ECO:0000315 |
P |
Figure 5D: Knockdown of caprin 2 showed that although caprin 2 interacts with LRP6 phosphorylation, caprin 2 overxpression and Wnt3a stimulation lead to the increased phosphorylation of LRP6. |
complete | |||||
| GO:0032403 |
protein complex binding |
ECO:0000021 |
UniProtKB:O75197 UniProtKB:O15169
|
F |
Figure 5B: Co-iummunoprecipitation showed that caprin 2 enhanced the interaction between Axin and LRP5. |
complete | ||||
| GO:0019901 |
protein kinase binding |
ECO:0000021 |
|
F |
Figure 5B: Caprin-2 enhanced interaction between Axin and LRP5 but the interaction was notable elevated when caprin 2 cotransfected with GSK3beta |
complete | ||||
|
involved_in |
GO:0090263 |
positive regulation of canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032092 |
positive regulation of protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050775 |
positive regulation of dendrite morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030308 |
negative regulation of cell growth |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05A80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050775 |
positive regulation of dendrite morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05A80 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0017148 |
negative regulation of translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0040008 |
regulation of growth |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 Ding, Y et al. (2008) Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J. Cell Biol. 182 865-72 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Aerbajinai, W et al. (2004) Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth. J. Biol. Chem. 279 1916-21 PubMed GONUTS page
c
n
p
- GO:0005886 ! plasma membrane
- GO:0030177 ! positive regulation of Wnt signaling pathway
- GO:0050775 ! positive regulation of dendrite morphogenesis
- GO:0042327 ! positive regulation of phosphorylation
- GO:0090263 ! positive regulation of canonical Wnt signaling pathway
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0032092 ! positive regulation of protein binding
- GO:0061003 ! positive regulation of dendritic spine morphogenesis
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- Primates
- GO:0032403 ! protein complex binding
- GO:0019901 ! protein kinase binding
