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HUMAN:CAH1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CA1 | |
| Protein Name(s) | Carbonic anhydrase 1
Carbonate dehydratase I Carbonic anhydrase B CAB Carbonic anhydrase I CA-I | |
| External Links | ||
| UniProt | P00915 | |
| EMBL | X05014 M33987 BC027890 | |
| CCDS | CCDS6237.1 | |
| PIR | JQ0786 | |
| RefSeq | NP_001122301.1 NP_001122302.1 NP_001122303.1 NP_001158302.1 NP_001729.1 | |
| UniGene | Hs.23118 | |
| PDB | 1AZM 1BZM 1CRM 1CZM 1HCB 1HUG 1HUH 1J9W 1JV0 2CAB 2FOY 2FW4 2IT4 2NMX 2NN1 2NN7 3LXE 3W6H 3W6I | |
| PDBsum | 1AZM 1BZM 1CRM 1CZM 1HCB 1HUG 1HUH 1J9W 1JV0 2CAB 2FOY 2FW4 2IT4 2NMX 2NN1 2NN7 3LXE 3W6H 3W6I | |
| ProteinModelPortal | P00915 | |
| SMR | P00915 | |
| BioGrid | 107214 | |
| IntAct | P00915 | |
| STRING | 9606.ENSP00000256119 | |
| BindingDB | P00915 | |
| ChEMBL | CHEMBL2095180 | |
| DrugBank | DB00819 DB00381 DB00436 DB00562 DB01194 DB00880 DB00606 DB01119 DB01144 DB00869 DB01031 DB00999 DB00774 DB00703 DB00423 DB00232 DB01325 DB01021 DB00909 | |
| GuidetoPHARMACOLOGY | 2597 | |
| PhosphoSite | P00915 | |
| DMDM | 115449 | |
| DOSAC-COBS-2DPAGE | P00915 | |
| REPRODUCTION-2DPAGE | IPI00215983 P00915 | |
| UCD-2DPAGE | P00915 | |
| PaxDb | P00915 | |
| PeptideAtlas | P00915 | |
| PRIDE | P00915 | |
| DNASU | 759 | |
| Ensembl | ENST00000431316 ENST00000523022 ENST00000523953 ENST00000542576 | |
| GeneID | 759 | |
| KEGG | hsa:759 | |
| UCSC | uc003ydh.3 | |
| CTD | 759 | |
| GeneCards | GC08M086315 | |
| HGNC | HGNC:1368 | |
| HPA | CAB025790 HPA006558 | |
| MIM | 114800 | |
| neXtProt | NX_P00915 | |
| PharmGKB | PA25984 | |
| eggNOG | COG3338 | |
| HOGENOM | HOG000112637 | |
| HOVERGEN | HBG002837 | |
| InParanoid | P00915 | |
| KO | K01672 | |
| OMA | VTWIICK | |
| OrthoDB | EOG7WMCK7 | |
| PhylomeDB | P00915 | |
| TreeFam | TF316425 | |
| BRENDA | 4.2.1.1 | |
| Reactome | REACT_121123 REACT_121329 REACT_121380 | |
| SABIO-RK | P00915 | |
| EvolutionaryTrace | P00915 | |
| GeneWiki | CA1_(gene) | |
| GenomeRNAi | 759 | |
| NextBio | 3070 | |
| PRO | PR:P00915 | |
| Proteomes | UP000005640 | |
| Bgee | P00915 | |
| CleanEx | HS_CA1 | |
| ExpressionAtlas | P00915 | |
| Genevestigator | P00915 | |
| GO | GO:0005829 GO:0070062 GO:0004089 GO:0008270 GO:0015701 GO:0006730 GO:0044281 | |
| Gene3D | 3.10.200.10 | |
| InterPro | IPR001148 IPR023561 IPR018338 IPR018442 | |
| PANTHER | PTHR18952 PTHR18952:SF82 | |
| Pfam | PF00194 | |
| SMART | SM01057 | |
| SUPFAM | SSF51069 | |
| PROSITE | PS00162 PS51144 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016836 |
hydro-lyase activity |
ECO:0000314 |
F |
Figure 1 |
complete | |||||
| GO:0004089 |
carbonate dehydratase activity |
ECO:0000315 |
F |
Table 1 |
complete | |||||
| GO:0004064 |
hydrolase activity |
ECO:0000315 |
F |
Table 4 |
complete | |||||
| GO:0004089 |
carbonate dehydratase activity |
ECO:0000315 |
F |
Table 2 |
complete | |||||
| GO:0004089 |
carbonate dehydratase activity |
ECO:0000314 |
F |
Figure 5 |
complete | |||||
| GO:0004064 |
arylesterase activity |
ECO:0000315 |
F |
Table 4 |
complete | |||||
|
enables |
GO:0004089 |
carbonate dehydratase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004064 |
arylesterase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016836 |
hydro-lyase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004089 |
carbonate dehydratase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006730 |
one-carbon metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004089 |
carbonate dehydratase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004089 |
carbonate dehydratase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035722 |
interleukin-12-mediated signaling pathway |
Reactome:R-HSA-9020591 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0015701 |
bicarbonate transport |
Reactome:R-HSA-1475029 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8950623 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Behravan, G et al. (1990) Fine tuning of the catalytic properties of carbonic anhydrase. Studies of a Thr200----His variant of human isoenzyme II. Eur. J. Biochem. 190 351-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Engstrand, C et al. (1995) Catalytic and inhibitor-binding properties of some active-site mutants of human carbonic anhydrase I. Eur. J. Biochem. 229 696-702 PubMed GONUTS page
- ↑ Khalifah, RG (1971) The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. J. Biol. Chem. 246 2561-73 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Lowe, N et al. (1990) Structure and methylation patterns of the gene encoding human carbonic anhydrase I. Gene 93 277-83 PubMed GONUTS page
