HUMAN:CADH5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CDH5
Protein Name(s)	Cadherin-5 7B4 antigen Vascular endothelial cadherin VE-cadherin
External Links
UniProt	P33151
EMBL	X79981 U84722 AB035304 BC096363 BC096364 BC117520 X59796
CCDS	CCDS10804.1
PIR	S49893
RefSeq	NP_001786.2
UniGene	Hs.76206
ProteinModelPortal	P33151
SMR	P33151
BioGrid	107438
DIP	DIP-41172N
IntAct	P33151
MINT	MINT-235470
STRING	9606.ENSP00000344115
DrugBank	DB05685 DB00480
iPTMnet	P33151
PhosphoSitePlus	P33151
UniCarbKB	P33151
BioMuta	CDH5
DMDM	322510142
MaxQB	P33151
PaxDb	P33151
PeptideAtlas	P33151
PRIDE	P33151
TopDownProteomics	P33151-1
Ensembl	ENST00000341529 ENST00000614547
GeneID	1003
KEGG	hsa:1003
UCSC	uc002eom.5
CTD	1003
DisGeNET	1003
GeneCards	CDH5
H-InvDB	HIX0038527
HGNC	HGNC:1764
HPA	CAB028366
MIM	601120
neXtProt	NX_P33151
OpenTargets	ENSG00000179776
PharmGKB	PA26301
eggNOG	KOG3594 ENOG410XQHI
GeneTree	ENSGT00760000118954
HOGENOM	HOG000231252
HOVERGEN	HBG005217
InParanoid	P33151
KO	K06533
OMA	HGKSVPE
OrthoDB	EOG091G03WQ
PhylomeDB	P33151
TreeFam	TF329887
Reactome	[www.reactome.org/content/detail/R-HSA-418990 R-HSA-418990] [www.reactome.org/content/detail/R-HSA-5218920 R-HSA-5218920]
SIGNOR	P33151
ChiTaRS	CDH5
GeneWiki	VE-cadherin
GenomeRNAi	1003
PMAP-CutDB	P33151
PRO	PR:P33151
Proteomes	UP000005640
Bgee	ENSG00000179776
CleanEx	HS_CDH5
ExpressionAtlas	P33151
Genevisible	P33151
GO	GO:0005912 GO:0005923 GO:0030054 GO:0009986 GO:0005911 GO:0009897 GO:0016021 GO:0016020 GO:0005886 GO:0008013 GO:0005509 GO:0044325 GO:0005102 GO:0034332 GO:0001955 GO:0007043 GO:0007156 GO:0008285 GO:1903142 GO:2000114 GO:0016337 GO:0007179
Gene3D	2.60.350.10 2.60.40.60 4.10.900.10
InterPro	IPR002126 IPR015919 IPR020894 IPR000233 IPR027397 IPR030052 IPR023226
PANTHER	PTHR24027:SF381
Pfam	PF00028 PF01049
PRINTS	PR00205
SMART	SM00112
SUPFAM	SSF49313
PROSITE	PS00232 PS50268

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:22391569^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000209905_9606	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:25893857^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35968	F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:25978380^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0005829	cytosol	PMID:28428220^[4]	ECO:0000314			C		Fig. 5 Parts L and M details the colocalization of CDH5 with CKLF3 throughout the endothelial cytosol. The organism of the gene used is human, and the gene is referred to as VE-cadherin in the experiment while UniProt refers to it as CDH5. The colocalized protein, CKLF3, is referred to as CMTM3 throughout the experiment and as CKLF3 by UniProt, with accession Q96MX0.	complete CACAO 12744
part_of	GO:0005886	plasma membrane	PMID:25978380^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:28112401^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000096022_9606	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21168935^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P01137) occurs_in:(CL:1001602)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:21168935^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001602)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:23288152^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:2000008) part_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	PMID:23288152^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1903142	positive regulation of establishment of endothelial barrier	PMID:23288152^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:23288152^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:2000008)	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:19996314^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UBN4	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:18287330^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:19996314^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:12088286^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99571	F		Seeded From UniProt	complete
involved_in	GO:2000114	regulation of establishment of cell polarity	PMID:20332120^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55284	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:20332120^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000114	regulation of establishment of cell polarity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 PANTHER:PTN000616731 UniProtKB:P33151	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 MGI:MGI:88354 MGI:MGI:88356 PANTHER:PTN000616280 RGD:69280 UniProtKB:O93319 UniProtKB:P12830 UniProtKB:Q86UP0	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 UniProtKB:P10288 UniProtKB:P55290	F		Seeded From UniProt	complete
involved_in	GO:0044331	cell-cell adhesion mediated by cadherin	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN000616280 UniProtKB:P10288	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99551 PANTHER:PTN000616280	F		Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 UniProtKB:P12830 ZFIN:ZDB-GENE-990415-171	P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88354 PANTHER:PTN000616280 UniProtKB:P12830 UniProtKB:P19022 ZFIN:ZDB-GENE-990415-171	C		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095414 MGI:MGI:88354 MGI:MGI:88355 PANTHER:PTN000616280 RGD:2321 RGD:69280 UniProtKB:P55290	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095414 MGI:MGI:88354 MGI:MGI:88355 PANTHER:PTN000616280 UniProtKB:P10288 UniProtKB:P33150 UniProtKB:P33151	C		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88354 PANTHER:PTN000616280	F		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095414 MGI:MGI:88355 MGI:MGI:99218 PANTHER:PTN000616280 UniProtKB:P55290	P		Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 UniProtKB:P33151	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 PANTHER:PTN000616731	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 MGI:MGI:88354 MGI:MGI:88356 PANTHER:PTN000616280 RGD:69280 UniProtKB:P10288 UniProtKB:P12830 UniProtKB:P19022 UniProtKB:P33151	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 MGI:MGI:107435 MGI:MGI:1095414 MGI:MGI:88354 MGI:MGI:88355 MGI:MGI:88356 MGI:MGI:99217 MGI:MGI:99551 PANTHER:PTN000616280 RGD:619745 RGD:621089 RGD:69279 RGD:69280 UniProtKB:O93319 UniProtKB:P10288 UniProtKB:P12830 UniProtKB:P19022 UniProtKB:P22223 UniProtKB:P33151 UniProtKB:P55283 UniProtKB:P55290 UniProtKB:Q6ZTQ4 UniProtKB:Q90763 ZFIN:ZDB-GENE-010606-1	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88354 PANTHER:PTN000616280 UniProtKB:Q86UP0	F		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 ZFIN:ZDB-GENE-990415-171	P		Seeded From UniProt	complete
involved_in	GO:2000114	regulation of establishment of cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	C		Seeded From UniProt	complete
involved_in	GO:0001955	blood vessel maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55284 ensembl:ENSMUSP00000034339	P		Seeded From UniProt	complete
involved_in	GO:0001955	blood vessel maturation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030052	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000233 InterPro:IPR002126 InterPro:IPR015919 InterPro:IPR030052	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894 InterPro:IPR030052	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000233 InterPro:IPR002126	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126 InterPro:IPR015919	C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039808	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:9219219^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PMID:9219219^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9219219^[13] Reactome:R-HSA-5357477 Reactome:R-HSA-419002 Reactome:R-HSA-419001	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	Reactome:R-HSA-418990	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Muramatsu, F et al. (2013) microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin. Oncogene 32 414-21 PubMed GONUTS page
↑ Yamana, S et al. (2015) The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. PLoS ONE 10 e0124259 PubMed GONUTS page
↑ ^3.0 ^3.1 Kugelmann, D et al. (2015) Adducin is involved in endothelial barrier stabilization. PLoS ONE 10 e0126213 PubMed GONUTS page
↑ Chrifi, I et al. (2017) CMTM3 (CKLF-Like Marvel Transmembrane Domain 3) Mediates Angiogenesis by Regulating Cell Surface Availability of VE-Cadherin in Endothelial Adherens Junctions. Arterioscler. Thromb. Vasc. Biol. PubMed GONUTS page
↑ Gu, W et al. (2017) MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin. FEBS Lett. 591 513-526 PubMed GONUTS page
↑ ^6.0 ^6.1 Shen, W et al. (2011) Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium. Eur. J. Cell Biol. 90 323-32 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Kluger, MS et al. (2013) Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells. Arterioscler. Thromb. Vasc. Biol. 33 489-500 PubMed GONUTS page
↑ ^8.0 ^8.1 Graziani, A et al. (2010) Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. J. Biol. Chem. 285 4213-23 PubMed GONUTS page
↑ Guo, M et al. (2008) VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability. Am. J. Physiol., Cell Physiol. 294 C977-84 PubMed GONUTS page
↑ Glass, R et al. (2002) P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells. Cell. Mol. Life Sci. 59 870-81 PubMed GONUTS page
↑ ^11.0 ^11.1 Lampugnani, MG et al. (2010) CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J. Cell. Sci. 123 1073-80 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Ali, J et al. (1997) Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. Microcirculation 4 267-77 PubMed GONUTS page

[PMID:22391569-1] Muramatsu, F et al. (2013) microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin. Oncogene 32 414-21 PubMed GONUTS page

[PMID:25893857-2] Yamana, S et al. (2015) The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. PLoS ONE 10 e0124259 PubMed GONUTS page

[PMID:25978380-3] 3.0 ^3.1 Kugelmann, D et al. (2015) Adducin is involved in endothelial barrier stabilization. PLoS ONE 10 e0126213 PubMed GONUTS page

[PMID:28428220-4] Chrifi, I et al. (2017) CMTM3 (CKLF-Like Marvel Transmembrane Domain 3) Mediates Angiogenesis by Regulating Cell Surface Availability of VE-Cadherin in Endothelial Adherens Junctions. Arterioscler. Thromb. Vasc. Biol. PubMed GONUTS page

[PMID:28112401-5] Gu, W et al. (2017) MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin. FEBS Lett. 591 513-526 PubMed GONUTS page

[PMID:21168935-6] 6.0 ^6.1 Shen, W et al. (2011) Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium. Eur. J. Cell Biol. 90 323-32 PubMed GONUTS page

[PMID:23288152-7] 7.0 ^7.1 ^7.2 ^7.3 Kluger, MS et al. (2013) Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells. Arterioscler. Thromb. Vasc. Biol. 33 489-500 PubMed GONUTS page

[PMID:19996314-8] 8.0 ^8.1 Graziani, A et al. (2010) Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. J. Biol. Chem. 285 4213-23 PubMed GONUTS page

[PMID:18287330-9] Guo, M et al. (2008) VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability. Am. J. Physiol., Cell Physiol. 294 C977-84 PubMed GONUTS page

[PMID:12088286-10] Glass, R et al. (2002) P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells. Cell. Mol. Life Sci. 59 870-81 PubMed GONUTS page

[PMID:20332120-11] 11.0 ^11.1 Lampugnani, MG et al. (2010) CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J. Cell. Sci. 123 1073-80 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9219219-13] 13.0 ^13.1 ^13.2 Ali, J et al. (1997) Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. Microcirculation 4 267-77 PubMed GONUTS page

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HUMAN:CADH5

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