HUMAN:BST2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BST2
Protein Name(s)	Bone marrow stromal antigen 2 BST-2 HM1.24 antigen Tetherin
External Links
UniProt	Q10589
EMBL	D28137 AK223124 AK291099 AC010319 CH471106 BC033873
CCDS	CCDS12358.1
PIR	A56836
RefSeq	NP_004326.1
UniGene	Hs.118110
PDB	2LK9 2X7A 2XG7 3MQ7 3MQ9 3MQB 3MQC 3NWH 4P6Z
PDBsum	2LK9 2X7A 2XG7 3MQ7 3MQ9 3MQB 3MQC 3NWH 4P6Z
ProteinModelPortal	Q10589
SMR	Q10589
BioGrid	107149
DIP	DIP-53216N
IntAct	Q10589
MINT	MINT-8402291
STRING	9606.ENSP00000252593
PhosphoSite	Q10589
DMDM	1705508
MaxQB	Q10589
PaxDb	Q10589
PeptideAtlas	Q10589
PRIDE	Q10589
DNASU	684
Ensembl	ENST00000252593
GeneID	684
KEGG	hsa:684
UCSC	uc002ngl.3
CTD	684
GeneCards	GC19M017513
HGNC	HGNC:1119
HPA	HPA017060
MIM	600534
neXtProt	NX_Q10589
PharmGKB	PA25436
eggNOG	NOG41121
GeneTree	ENSGT00390000013782
HOGENOM	HOG000013084
HOVERGEN	HBG004902
InParanoid	Q10589
KO	K06731
OMA	LNHKLQD
OrthoDB	EOG7D59R5
PhylomeDB	Q10589
TreeFam	TF338345
ChiTaRS	BST2
EvolutionaryTrace	Q10589
GeneWiki	Tetherin
GenomeRNAi	684
NextBio	2816
PRO	PR:Q10589
Proteomes	UP000005640
Bgee	Q10589
CleanEx	HS_BST2
ExpressionAtlas	Q10589
Genevestigator	Q10589
GO	GO:0031225 GO:0016324 GO:0009986 GO:0005737 GO:0070062 GO:0005794 GO:0005887 GO:0005770 GO:0016020 GO:0045121 GO:0005886 GO:0008191 GO:0044822 GO:0042803 GO:0004871 GO:0042113 GO:0008283 GO:0007267 GO:0051607 GO:0006959 GO:0045087 GO:0007275 GO:0030308 GO:0030336 GO:0010951 GO:1901253 GO:0002737 GO:0045071 GO:0043123 GO:0032956 GO:0035455 GO:0035456 GO:0034341 GO:0009615 GO:0007165
InterPro	IPR024886
PANTHER	PTHR15190

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005771	multivesicular body	PMID:22072966^[1]	ECO:0000315			C		Fig. 6D	complete CACAO 3056
	GO:0030139	endocytic vesicle	PMID:22072966^[1]	ECO:0000315			C		Fig. 6B and Fig. 7B	complete CACAO 3260
	GO:0009986	cell surface	PMID:22072966^[1]	ECO:0000315			C		Fig. 9	complete CACAO 3261
part_of	GO:0009986	cell surface	PMID:22072966^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	PMID:22072966^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:1901253	negative regulation of intracellular transport of viral material	PMID:20686043^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901253	negative regulation of intracellular transport of viral material	PMID:20943977^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901253	negative regulation of intracellular transport of viral material	PMID:19036818^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:20399176^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:19036818^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	PMID:20943977^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12761501^[10]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:20399176^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q10589	F		Seeded From UniProt	complete
involved_in	GO:0035456	response to interferon-beta	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R2Q8	P		Seeded From UniProt	complete
involved_in	GO:0035455	response to interferon-alpha	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R2Q8	P		Seeded From UniProt	complete
involved_in	GO:0034341	response to interferon-gamma	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R2Q8	P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q811A2	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:22065321^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:22065321^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q811A2	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q811A2	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R2Q8	C		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:19036818^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:20943977^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:20686043^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008191	metalloendopeptidase inhibitor activity	PMID:22065321^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19036818^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20943977^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20686043^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20399176^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:22065321^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002737	negative regulation of plasmacytoid dendritic cell cytokine production	PMID:19564354^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000390342 UniProtKB:Q10589	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1916800 PANTHER:PTN000390342 UniProtKB:Q10589	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1916800 PANTHER:PTN000390342 RGD:727849 UniProtKB:Q10589	C		Seeded From UniProt	complete
enables	GO:0008191	metalloendopeptidase inhibitor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000390342 UniProtKB:Q10589	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000390342 UniProtKB:Q10589	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20940320^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q10589	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20880831^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q10589	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19879838^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q10589	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008191	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008191	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024886	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070665	positive regulation of leukocyte proliferation	PMID:7607676^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	Reactome:R-HSA-909733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035577	azurophil granule membrane	Reactome:R-HSA-6798739	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6798739 Reactome:R-HSA-1015702	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C		Seeded From UniProt	complete
involved_in	GO:0042113	B cell activation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0075	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0152	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Caillet, M et al. (2011) Rab7A is required for efficient production of infectious HIV-1. PLoS Pathog. 7 e1002347 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Radoshitzky, SR et al. (2010) Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin. J. Virol. 84 10569-80 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Weidner, JM et al. (2010) Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J. Virol. 84 12646-57 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Jouvenet, N et al. (2009) Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. J. Virol. 83 1837-44 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Hinz, A et al. (2010) Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain. Cell Host Microbe 7 314-23 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Gu, G et al. (2012) BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity. J. Cell. Biochem. 113 1013-21 PubMed GONUTS page
↑ Cao, W et al. (2009) Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J. Exp. Med. 206 1603-14 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yang, H et al. (2010) Structural insight into the mechanisms of enveloped virus tethering by tetherin. Proc. Natl. Acad. Sci. U.S.A. 107 18428-32 PubMed GONUTS page
↑ Schubert, HL et al. (2010) Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations. Proc. Natl. Acad. Sci. U.S.A. 107 17951-6 PubMed GONUTS page
↑ Perez-Caballero, D et al. (2009) Tetherin inhibits HIV-1 release by directly tethering virions to cells. Cell 139 499-511 PubMed GONUTS page
↑ Ishikawa, J et al. (1995) Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics 26 527-34 PubMed GONUTS page

[PMID:22072966-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Caillet, M et al. (2011) Rab7A is required for efficient production of infectious HIV-1. PLoS Pathog. 7 e1002347 PubMed GONUTS page

[PMID:19946888-2] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19056867-3] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-4] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:20686043-5] 5.0 ^5.1 ^5.2 Radoshitzky, SR et al. (2010) Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin. J. Virol. 84 10569-80 PubMed GONUTS page

[PMID:20943977-6] 6.0 ^6.1 ^6.2 ^6.3 Weidner, JM et al. (2010) Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J. Virol. 84 12646-57 PubMed GONUTS page

[PMID:19036818-7] 7.0 ^7.1 ^7.2 ^7.3 Jouvenet, N et al. (2009) Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. J. Virol. 83 1837-44 PubMed GONUTS page

[PMID:20399176-8] 8.0 ^8.1 ^8.2 Hinz, A et al. (2010) Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain. Cell Host Microbe 7 314-23 PubMed GONUTS page

[PMID:22658674-9] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:12761501-10] Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page

[PMID:22065321-11] 11.0 ^11.1 ^11.2 ^11.3 Gu, G et al. (2012) BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity. J. Cell. Biochem. 113 1013-21 PubMed GONUTS page

[PMID:19564354-12] Cao, W et al. (2009) Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J. Exp. Med. 206 1603-14 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20940320-14] Yang, H et al. (2010) Structural insight into the mechanisms of enveloped virus tethering by tetherin. Proc. Natl. Acad. Sci. U.S.A. 107 18428-32 PubMed GONUTS page

[PMID:20880831-15] Schubert, HL et al. (2010) Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations. Proc. Natl. Acad. Sci. U.S.A. 107 17951-6 PubMed GONUTS page

[PMID:19879838-16] Perez-Caballero, D et al. (2009) Tetherin inhibits HIV-1 release by directly tethering virions to cells. Cell 139 499-511 PubMed GONUTS page

[PMID:7607676-17] Ishikawa, J et al. (1995) Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics 26 527-34 PubMed GONUTS page

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HUMAN:BST2

Contents

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Notes

References

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