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HUMAN:BRD4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | BRD4 (synonyms: HUNK1) | |
| Protein Name(s) | Bromodomain-containing protein 4
Protein HUNK1 | |
| External Links | ||
| UniProt | O60885 | |
| EMBL | AF386649 Y12059 AC004798 AC003111 AC005776 CH471106 BC035266 AY166680 | |
| CCDS | CCDS12328.1 CCDS46004.1 | |
| RefSeq | NP_055114.1 NP_490597.1 | |
| UniGene | Hs.187763 | |
| PDB | 2I8N 2LSP 2MJV 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4CFK 4CFL 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4J3I 4KV1 4KV4 4LR6 4LRG 4LYI 4LYS 4LYW 4LZR 4LZS 4MEN 4MEO 4MEP 4MEQ 4MR3 4MR4 4NQM 4NR8 4NUC 4NUD 4NUE 4O70 4O71 4O72 4O74 4O75 4O76 4O77 4O78 4O7A 4O7B 4O7C 4O7E 4O7F 4OGI 4OGJ 4PCE 4PCI 4PS5 4QZS 4UYD 4WIV | |
| PDBsum | 2I8N 2LSP 2MJV 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4CFK 4CFL 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4J3I 4KV1 4KV4 4LR6 4LRG 4LYI 4LYS 4LYW 4LZR 4LZS 4MEN 4MEO 4MEP 4MEQ 4MR3 4MR4 4NQM 4NR8 4NUC 4NUD 4NUE 4O70 4O71 4O72 4O74 4O75 4O76 4O77 4O78 4O7A 4O7B 4O7C 4O7E 4O7F 4OGI 4OGJ 4PCE 4PCI 4PS5 4QZS 4UYD 4WIV | |
| ProteinModelPortal | O60885 | |
| SMR | O60885 | |
| BioGrid | 117036 | |
| DIP | DIP-39776N | |
| IntAct | O60885 | |
| MINT | MINT-1176376 | |
| STRING | 9606.ENSP00000263377 | |
| BindingDB | O60885 | |
| ChEMBL | CHEMBL1163125 | |
| GuidetoPHARMACOLOGY | 1945 | |
| PhosphoSite | O60885 | |
| MaxQB | O60885 | |
| PaxDb | O60885 | |
| PeptideAtlas | O60885 | |
| PRIDE | O60885 | |
| Ensembl | ENST00000263377 ENST00000360016 ENST00000371835 | |
| GeneID | 23476 | |
| KEGG | hsa:23476 | |
| UCSC | uc002nar.3 uc002nas.3 uc002nat.3 | |
| CTD | 23476 | |
| GeneCards | GC19M015348 | |
| HGNC | HGNC:13575 | |
| HPA | HPA015055 | |
| MIM | 608749 | |
| neXtProt | NX_O60885 | |
| PharmGKB | PA25416 | |
| eggNOG | COG5076 | |
| GeneTree | ENSGT00760000119206 | |
| HOGENOM | HOG000231200 | |
| HOVERGEN | HBG004896 | |
| InParanoid | O60885 | |
| KO | K11722 | |
| OMA | FIATQVP | |
| PhylomeDB | O60885 | |
| TreeFam | TF317345 | |
| ChiTaRS | BRD4 | |
| EvolutionaryTrace | O60885 | |
| GeneWiki | BRD4 | |
| GenomeRNAi | 23476 | |
| NextBio | 45817 | |
| PMAP-CutDB | O60885 | |
| PRO | PR:O60885 | |
| Proteomes | UP000005640 | |
| Bgee | O60885 | |
| CleanEx | HS_BRD4 | |
| ExpressionAtlas | O60885 | |
| Genevestigator | O60885 | |
| GO | GO:0005694 GO:0000794 GO:0005737 GO:0000790 GO:0005634 GO:0008024 GO:0003682 GO:0003677 GO:0070577 GO:0002039 GO:0006974 GO:0006338 GO:0007059 GO:0044154 GO:0043983 GO:0001833 GO:2000002 GO:0043388 GO:0010971 GO:0043123 GO:0032968 GO:0045944 GO:0006468 GO:0050727 GO:1901407 GO:0000083 GO:0006351 GO:0016032 | |
| Gene3D | 1.20.920.10 | |
| InterPro | IPR001487 IPR018359 IPR027353 | |
| Pfam | PF00439 | |
| PRINTS | PR00503 | |
| SMART | SM00297 | |
| SUPFAM | SSF47370 | |
| PROSITE | PS00633 PS50014 PS51525 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008284 |
positive regulation of transcription during mitosis |
ECO:0000314 |
P |
Figure 1. BRD4 promotes proliferation in acute myeloid leukaemia cells. |
complete | |||||
|
involved_in |
GO:2001255 |
positive regulation of histone H3-K36 trimethylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0106140 |
P-TEFb complex binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001134 |
transcription regulator recruiting activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070577 |
lysine-acetylated histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q9P1W9)|has_regulation_target:(UniProtKB:P24385)|has_regulation_target:(UniProtKB:Q96C86) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901407 |
regulation of phosphorylation of RNA polymerase II C-terminal domain |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070577 |
lysine-acetylated histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070577 |
lysine-acetylated histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070577 |
lysine-acetylated histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050727 |
regulation of inflammatory response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032968 |
positive regulation of transcription elongation from RNA polymerase II promoter |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032968 |
positive regulation of transcription elongation from RNA polymerase II promoter |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0099122 |
RNA polymerase II C-terminal domain binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032968 |
positive regulation of transcription elongation from RNA polymerase II promoter |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010971 |
positive regulation of G2/M transition of mitotic cell cycle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008353 |
RNA polymerase II CTD heptapeptide repeat kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000794 |
condensed nuclear chromosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000083 |
regulation of transcription involved in G1/S transition of mitotic cell cycle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008353 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000002 |
negative regulation of DNA damage checkpoint |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070577 |
lysine-acetylated histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006338 |
chromatin remodeling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Stewart, HJ et al. (2013) BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1. Cancer Med 2 826-35 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Rahman, S et al. (2011) The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol. Cell. Biol. 31 2641-52 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Liu, W et al. (2013) Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell 155 1581-95 PubMed GONUTS page
- ↑ Konuma, T et al. (2017) Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4. Sci Rep 7 16272 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Zhang, W et al. (2012) Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J. Biol. Chem. 287 43137-55 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Wu, SY et al. (2013) Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting. Mol. Cell 49 843-57 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Filippakopoulos, P et al. (2010) Selective inhibition of BET bromodomains. Nature 468 1067-73 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Huang, B et al. (2009) Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol. Cell. Biol. 29 1375-87 PubMed GONUTS page
- ↑ 9.0 9.1 Devaiah, BN et al. (2012) BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc. Natl. Acad. Sci. U.S.A. 109 6927-32 PubMed GONUTS page
- ↑ 10.0 10.1 Yang, Z et al. (2008) Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression. Mol. Cell. Biol. 28 967-76 PubMed GONUTS page
- ↑ 11.0 11.1 Dey, A et al. (2000) A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. Mol. Cell. Biol. 20 6537-49 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 12.4 12.5 Floyd, SR et al. (2013) The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature 498 246-50 PubMed GONUTS page
c
n
o
- GO:2001255 ! obsolete positive regulation of histone H3-K36 trimethylation
- GO:0000083 ! obsolete regulation of transcription involved in G1/S transition of mitotic cell cycle
- GO:1901407 ! obsolete regulation of phosphorylation of RNA polymerase II C-terminal domain
- GO:0001134 ! obsolete transcription regulator recruiting activity
p
- GO:0106140 ! P-TEFb complex binding
- GO:0002039 ! p53 binding
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0010971 ! positive regulation of G2/M transition of mitotic cell cycle
- GO:0032968 ! positive regulation of transcription elongation by RNA polymerase II
- GO:0043123 ! positive regulation of canonical NF-kappaB signal transduction
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- Primates
- GO:0006468 ! protein phosphorylation
r
