HUMAN:BMPR2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BMPR2 (synonyms: PPH1)
Protein Name(s)	Bone morphogenetic protein receptor type-2 BMP type-2 receptor BMPR-2 Bone morphogenetic protein receptor type II BMP type II receptor BMPR-II
External Links
UniProt	Q13873
EMBL	U25110 Z48923 D50516 U20165 AC009960 AC073410 AC064836 CH471063 BC052985
CCDS	CCDS33361.1
PIR	I38935
RefSeq	NP_001195.2
UniGene	Hs.471119
PDB	2HLQ 3G2F
PDBsum	2HLQ 3G2F
ProteinModelPortal	Q13873
SMR	Q13873
BioGrid	107127
DIP	DIP-5794N
IntAct	Q13873
MINT	MINT-124272
STRING	9606.ENSP00000363708
BindingDB	Q13873
ChEMBL	CHEMBL5467
GuidetoPHARMACOLOGY	1794
PhosphoSite	Q13873
DMDM	12643724
MaxQB	Q13873
PaxDb	Q13873
PRIDE	Q13873
DNASU	659
Ensembl	ENST00000374574 ENST00000374580
GeneID	659
KEGG	hsa:659
UCSC	uc002uzf.4 uc010ftr.3
CTD	659
GeneCards	GC02P203205
GeneReviews	BMPR2
HGNC	HGNC:1078
HPA	HPA017385
MIM	178600 265450 600799
neXtProt	NX_Q13873
Orphanet	275777 275766 31837
PharmGKB	PA25388
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000043088
HOVERGEN	HBG050705
InParanoid	Q13873
KO	K04671
OMA	DHYKPAI
OrthoDB	EOG7JHM5B
PhylomeDB	Q13873
TreeFam	TF314724
Reactome	REACT_12034
SignaLink	Q13873
ChiTaRS	BMPR2
EvolutionaryTrace	Q13873
GeneWiki	BMPR2
GenomeRNAi	659
NextBio	2680
PRO	PR:Q13873
Proteomes	UP000005640
Bgee	Q13873
CleanEx	HS_BMPR2
Genevestigator	Q13873
GO	GO:0016324 GO:0009925 GO:0005901 GO:0009986 GO:0005737 GO:0030425 GO:0005615 GO:0044214 GO:0005887 GO:0043025 GO:0005886 GO:0016362 GO:0005524 GO:0046872 GO:0004702 GO:0005024 GO:0032924 GO:0009952 GO:0060840 GO:0001974 GO:0030509 GO:0007420 GO:0009267 GO:0002063 GO:0060173 GO:0048286 GO:0001946 GO:0060836 GO:0001707 GO:0030308 GO:1902731 GO:2000279 GO:0003085 GO:0045906 GO:0048842 GO:0030513 GO:0030501 GO:0010595 GO:0001938 GO:0010634 GO:0045669 GO:0010862 GO:0042127 GO:0014916 GO:0061298 GO:0006366 GO:0007178 GO:0048010 GO:0060841
InterPro	IPR000472 IPR015770 IPR011009 IPR000719 IPR017441 IPR000333
PANTHER	PTHR23255 PTHR23255:SF63
Pfam	PF01064 PF00069
SUPFAM	SSF56112
PROSITE	PS00107 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0003177	pulmonary valve development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0003176	aortic valve development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0060413	atrial septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0061626	pharyngeal arch artery morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P	has_regulation_target:(UniProtKB:Q15063) occurs_in:(UBERON:0005967)	Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0003197	endocardial cushion development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0003181	atrioventricular valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0061626	pharyngeal arch artery morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0048738	cardiac muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P	occurs_in:(UBERON:0005623)	Seeded From UniProt	complete
involved_in	GO:0003186	tricuspid valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:1905314	semi-lunar valve development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0003183	mitral valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:25468996^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:18326817^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18326817^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P81172) part_of:(GO:0071773)	Seeded From UniProt	complete
enables	GO:0036122	BMP binding	PMID:21976273^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00238	F		Seeded From UniProt	complete
enables	GO:0036122	BMP binding	PMID:21976273^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P36894	F		Seeded From UniProt	complete
involved_in	GO:0072577	endothelial cell apoptotic process	PMID:25187962^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:25187962^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	PMID:25187962^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F6RIN4	P		Seeded From UniProt	complete
involved_in	GO:0060350	endochondral bone morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F6RIN4	P		Seeded From UniProt	complete
involved_in	GO:0030166	proteoglycan biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F6RIN4	P		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42124	P		Seeded From UniProt	complete
involved_in	GO:0060350	endochondral bone morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42124	P		Seeded From UniProt	complete
involved_in	GO:0030166	proteoglycan biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42124	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22664934^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
involved_in	GO:1902731	negative regulation of chondrocyte proliferation	PMID:9442116^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:9442116^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002063	chondrocyte development	PMID:9442116^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	PMID:19366699^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061298	retina vasculature development in camera-type eye	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0060841	venous blood vessel development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0060840	artery development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0060836	lymphatic endothelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0048286	lung alveolus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0045906	negative regulation of vasoconstriction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:18436533^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19366699^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:12045205^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:18436533^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:18436533^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014916	regulation of lung blood pressure	PMID:18364108^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014916	regulation of lung blood pressure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:19366699^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q15797) has_regulation_target:(UniProtKB:Q99717)	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:15657086^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	PMID:12045205^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:12045205^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005901	caveola	PMID:15657086^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:12045205^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15657086^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003085	negative regulation of systemic arterial blood pressure	PMID:18364108^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35607	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:11502704^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	PMID:17992660^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:12819188^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:17992660^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	PMID:12819188^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:17992660^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:17992660^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095407 PANTHER:PTN001147423	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005026	transforming growth factor beta receptor activity, type II	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001147423 RGD:70964	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016362	P		Seeded From UniProt	complete
involved_in	GO:0060041	retina development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
involved_in	GO:1905314	semi-lunar valve development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	F		Seeded From UniProt	complete
involved_in	GO:0061298	retina vasculature development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0060841	venous blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0060840	artery development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0060836	lymphatic endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0060413	atrial septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0048842	positive regulation of axon extension involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0048286	lung alveolus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0045906	negative regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0014916	regulation of lung blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	C		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	C		Seeded From UniProt	complete
involved_in	GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0003197	endocardial cushion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0003177	pulmonary valve development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0003176	aortic valve development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0001893	maternal placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472	C		Seeded From UniProt	complete
part_of	GO:0044214	spanning component of plasma membrane	PMID:9442116^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	Reactome:R-HSA-201451	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016362	activin receptor activity, type II	Reactome:R-HSA-201443	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-202604 Reactome:R-HSA-201821 Reactome:R-HSA-201648 Reactome:R-HSA-201476 Reactome:R-HSA-201475 Reactome:R-HSA-201457 Reactome:R-HSA-201453 Reactome:R-HSA-201443	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^2.0 ^2.1 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page
↑ ^3.0 ^3.1 Schwaerzer, GK et al. (2012) New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. J. Bone Miner. Res. 27 429-42 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Wang, H et al. (2014) Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations. PLoS ONE 9 e106703 PubMed GONUTS page
↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Enomoto-Iwamoto, M et al. (1998) Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes. J. Cell Biol. 140 409-18 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Upton, PD et al. (2009) Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J. Biol. Chem. 284 15794-804 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Rudarakanchana, N et al. (2002) Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension. Hum. Mol. Genet. 11 1517-25 PubMed GONUTS page
↑ ^10.0 ^10.1 Fu, LJ et al. (2008) A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension. Chin. Med. J. 121 399-404 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Nohe, A et al. (2005) Dynamics and interaction of caveolin-1 isoforms with BMP-receptors. J. Cell. Sci. 118 643-50 PubMed GONUTS page
↑ Morrell, NW et al. (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104 790-5 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Southwood, M et al. (2008) Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol. 214 85-95 PubMed GONUTS page
↑ ^14.0 ^14.1 Langenfeld, EM et al. (2003) The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis 24 1445-54 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25468996-1] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:18326817-2] 2.0 ^2.1 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page

[PMID:21976273-3] 3.0 ^3.1 Schwaerzer, GK et al. (2012) New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. J. Bone Miner. Res. 27 429-42 PubMed GONUTS page

[PMID:25187962-4] 4.0 ^4.1 ^4.2 Wang, H et al. (2014) Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations. PLoS ONE 9 e106703 PubMed GONUTS page

[PMID:22664934-5] Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page

[PMID:9442116-6] 6.0 ^6.1 ^6.2 ^6.3 Enomoto-Iwamoto, M et al. (1998) Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes. J. Cell Biol. 140 409-18 PubMed GONUTS page

[PMID:19366699-7] 7.0 ^7.1 ^7.2 Upton, PD et al. (2009) Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J. Biol. Chem. 284 15794-804 PubMed GONUTS page

[PMID:18436533-8] 8.0 ^8.1 ^8.2 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page

[PMID:12045205-9] 9.0 ^9.1 ^9.2 ^9.3 Rudarakanchana, N et al. (2002) Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension. Hum. Mol. Genet. 11 1517-25 PubMed GONUTS page

[PMID:18364108-10] 10.0 ^10.1 Fu, LJ et al. (2008) A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension. Chin. Med. J. 121 399-404 PubMed GONUTS page

[PMID:15657086-11] 11.0 ^11.1 ^11.2 Nohe, A et al. (2005) Dynamics and interaction of caveolin-1 isoforms with BMP-receptors. J. Cell. Sci. 118 643-50 PubMed GONUTS page

[PMID:11502704-12] Morrell, NW et al. (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104 790-5 PubMed GONUTS page

[PMID:17992660-13] 13.0 ^13.1 ^13.2 ^13.3 Southwood, M et al. (2008) Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol. 214 85-95 PubMed GONUTS page

[PMID:12819188-14] 14.0 ^14.1 Langenfeld, EM et al. (2003) The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis 24 1445-54 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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