HUMAN:BICD1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BICD1
Protein Name(s)	Protein bicaudal D homolog 1 Bic-D 1
External Links
UniProt	Q96G01
EMBL	U90028 U90030 AK290188 AK313430 AC016954 AC026356 AC048344 AC087245 AC087316 CH471116 BC010091
CCDS	CCDS44859.1 CCDS8726.1
RefSeq	NP_001003398.1 NP_001705.2
UniGene	Hs.505202 Hs.633204
ProteinModelPortal	Q96G01
SMR	Q96G01
BioGrid	107105
IntAct	Q96G01
MINT	MINT-206187
STRING	9606.ENSP00000281474
PhosphoSite	Q96G01
DMDM	209572759
MaxQB	Q96G01
PaxDb	Q96G01
PRIDE	Q96G01
Ensembl	ENST00000281474 ENST00000548411 ENST00000551848
GeneID	636
KEGG	hsa:636
UCSC	uc001rku.3
CTD	636
GeneCards	GC12P032259
H-InvDB	HIX0010532
HGNC	HGNC:1049
HPA	HPA041309
MIM	602204
neXtProt	NX_Q96G01
PharmGKB	PA25352
eggNOG	NOG291306
GeneTree	ENSGT00390000004114
HOGENOM	HOG000261658
HOVERGEN	HBG050686
InParanoid	Q96G01
OMA	NHINISV
OrthoDB	EOG7BZVRK
PhylomeDB	Q96G01
TreeFam	TF323833
ChiTaRS	BICD1
GeneWiki	BICD1
GenomeRNAi	636
NextBio	2572
PRO	PR:Q96G01
Proteomes	UP000005640
Bgee	Q96G01
CleanEx	HS_BICD1
ExpressionAtlas	Q96G01
Genevestigator	Q96G01
GO	GO:0031410 GO:0005856 GO:0005829 GO:0005794 GO:0072517 GO:0016020 GO:0048471 GO:0005802 GO:0008093 GO:0034452 GO:0045502 GO:0031871 GO:0017137 GO:0005200 GO:0009653 GO:0008298 GO:0072393 GO:0072385 GO:1900275 GO:1900737 GO:0048260 GO:0033365 GO:1900276 GO:0006396 GO:0034063 GO:0016032
InterPro	IPR018477
PANTHER	PTHR31233
Pfam	PF09730

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019900	kinase binding	PMID:17139249^[1]	ECO:0000021		UniProtKB:P49841	F		Fig.3B,6A	complete
	GO:0019900	kinase binding	PMID:17139249^[1]	ECO:0000021		UniProtKB:A8MT37	F		Fig.3B	complete
	GO:0005515	protein binding	PMID:17139249^[1]	ECO:0000021		UniProtKB:Q8N4C6	F		Fig.8C	complete
	GO:0005813	centrosome	PMID:17139249^[1]	ECO:0000314			C		Fig.4 BICD1 was also present…..at the centrosome…	complete
enables	GO:0045505	dynein intermediate chain binding	PMID:17139249^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034452	dynactin binding	PMID:17139249^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13561 UniProtKB:Q14203	F		Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:17139249^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8TD16	P		Seeded From UniProt	complete
colocalizes_with	GO:0005794	Golgi apparatus	PMID:17139249^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0048471)	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:17139249^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(GO:0048471)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:17139249^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17139249^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
involved_in	GO:1904781	positive regulation of protein localization to centrosome	PMID:17139249^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8TD16	P	has_direct_input:(UniProtKB:Q8N4C6) regulates:(GO:0000226)	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:17562788^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900737	negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BR07	P		Seeded From UniProt	complete
involved_in	GO:1900737	negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D4ADZ2	P		Seeded From UniProt	complete
involved_in	GO:1900276	regulation of proteinase activated receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BR07	P		Seeded From UniProt	complete
involved_in	GO:1900275	negative regulation of phospholipase C activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BR07	P		Seeded From UniProt	complete
part_of	GO:0072517	host cell viral assembly compartment	PMID:20089649^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0072393	microtubule anchoring at microtubule organizing center	PMID:19825938^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BR07	P		Seeded From UniProt	complete
involved_in	GO:0072385	minus-end-directed organelle transport along microtubule	PMID:12447383^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:20089649^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048260	positive regulation of receptor-mediated endocytosis	PMID:20164183^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	PMID:12447383^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034452	dynactin binding	PMID:12447383^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034063	stress granule assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BR07	P		Seeded From UniProt	complete
involved_in	GO:0033365	protein localization to organelle	PMID:20089649^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033365	protein localization to organelle	PMID:12447383^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031871	proteinase activated receptor binding	PMID:20164183^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BR07	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:20089649^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:12447383^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	PMID:12447383^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20340	F		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	PMID:20089649^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12447383^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008093	cytoskeletal adaptor activity	PMID:12447383^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:20089649^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12447383^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:20089649^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:12447383^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008298	intracellular mRNA localization	PMID:9367685^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:9367685^[7]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008093	cytoskeletal adaptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018477	F		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018477	F		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:9367685^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006396	RNA processing	PMID:9367685^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005200	structural constituent of cytoskeleton	PMID:9367685^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0045298	tubulin complex	PMID:20164183^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8849353 Reactome:R-HSA-8849350 Reactome:R-HSA-8849348	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Fumoto, K et al. (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25 5670-82 PubMed GONUTS page
↑ Fuchs, E et al. (2007) Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J. Cell Biol. 177 1133-43 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Indran, SV et al. (2010) Bicaudal D1-dependent trafficking of human cytomegalovirus tegument protein pp150 in virus-infected cells. J. Virol. 84 3162-77 PubMed GONUTS page
↑ Loschi, M et al. (2009) Dynein and kinesin regulate stress-granule and P-body dynamics. J. Cell. Sci. 122 3973-82 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Matanis, T et al. (2002) Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat. Cell Biol. 4 986-92 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Swift, S et al. (2010) A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization. J. Biol. Chem. 285 11402-10 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Baens, M & Marynen, P (1997) A human homologue (BICD1) of the Drosophila bicaudal-D gene. Genomics 45 601-6 PubMed GONUTS page

[PMID:17139249-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Fumoto, K et al. (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25 5670-82 PubMed GONUTS page

[PMID:17562788-2] Fuchs, E et al. (2007) Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J. Cell Biol. 177 1133-43 PubMed GONUTS page

[PMID:20089649-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Indran, SV et al. (2010) Bicaudal D1-dependent trafficking of human cytomegalovirus tegument protein pp150 in virus-infected cells. J. Virol. 84 3162-77 PubMed GONUTS page

[PMID:19825938-4] Loschi, M et al. (2009) Dynein and kinesin regulate stress-granule and P-body dynamics. J. Cell. Sci. 122 3973-82 PubMed GONUTS page

[PMID:12447383-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Matanis, T et al. (2002) Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat. Cell Biol. 4 986-92 PubMed GONUTS page

[PMID:20164183-6] 6.0 ^6.1 ^6.2 Swift, S et al. (2010) A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization. J. Biol. Chem. 285 11402-10 PubMed GONUTS page

[PMID:9367685-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Baens, M & Marynen, P (1997) A human homologue (BICD1) of the Drosophila bicaudal-D gene. Genomics 45 601-6 PubMed GONUTS page

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HUMAN:BICD1

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