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PMID:9367685

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Citation

Baens, M and Marynen, P (1997) A human homologue (BICD1) of the Drosophila bicaudal-D gene. Genomics 45:601-6

Abstract

We previously isolated a cDNA fragment homologous to the Drosophila Bicaudal-D gene (Bic-D) using a hybridization selection procedure with cosmids derived from the short arm of human chromosome 12. A PCR-mediated cDNA cloning strategy was applied to obtain the coding sequence of the human homologue (BICD1) and to generate a partial mouse (Bicdh1) cDNA. The Drosophila Bicaudal-D gene encodes a coiled coil protein, characterized by five alpha-helix domains and a leucine zipper motif, that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Analysis of the predicted amino acid sequence of the BICD1 cDNA clones indicates that the sequence similarity is essentially limited to the amphipatic helices and the leucine zipper, but the conserved order of these domains suggests a similar function of the protein in mammalians. A database search further indicates the existence of a second human homologue on chromosome arm 9q and a Caenorhabditis elegans homologue. Northern blot analysis indicates that both the human and the murine homologues produce an mRNA species of congruent with9.5 kb expressed in brain, heart, and skeletal muscle and during mouse embryonic development. The conserved structural characteristics of the BICD1 protein and its expression in muscle and especially brain suggest that BICD1 is a component of a cytoskeleton-based mRNA sorting mechanism conserved during evolution.

Links

PubMed Online version:10.1006/geno.1997.4971

Keywords

Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cytoskeletal Proteins; Drosophila Proteins; Gene Expression Regulation, Developmental; Humans; Insect Proteins/genetics; Insect Proteins/metabolism; Leucine Zippers; Mice; Molecular Sequence Data; Proteins/genetics; Sequence Homology, Nucleic Acid; Tissue Distribution

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:BICD1

located_in

GO:0005856: cytoskeleton

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

HUMAN:BICD1

involved_in

GO:0008298: intracellular mRNA localization

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BICD1

part_of

GO:0005856: cytoskeleton

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

HUMAN:BICD1

involved_in

GO:0009653: anatomical structure morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BICD1

involved_in

GO:0006396: RNA processing

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BICD1

enables

GO:0005200: structural constituent of cytoskeleton

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete


See also

References

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