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HUMAN:BDNF

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) BDNF
Protein Name(s) Brain-derived neurotrophic factor

BDNF Abrineurin

External Links
UniProt P23560
EMBL M37762
M61176
M61181
X60201
AY054392
AY054393
AY054394
AY054395
AY054396
AY054397
AY054398
AY054399
AY054400
AF411339
EF674517
EF674518
EF674519
EF674520
EF674521
EF689009
EF689010
EF689011
EF689012
EF689013
EF689014
EF689015
EF689016
EF689017
EF689018
EF689019
EF689020
EF689021
X91251
AF400438
AY656701
AK289853
AK289763
AC104563
CH471064
CH471064
CH471064
CH471064
CH471064
CH471064
BC029795
AY011481
CCDS CCDS41628.1
CCDS44558.1
CCDS7865.1
CCDS7866.1
PIR B36208
RefSeq NP_001137277.1
NP_001137278.1
NP_001137279.1
NP_001137280.1
NP_001137281.1
NP_001137282.1
NP_001137283.1
NP_001137284.1
NP_001137285.1
NP_001137286.1
NP_001137288.1
NP_001700.2
NP_733927.1
NP_733928.1
NP_733929.1
NP_733930.1
NP_733931.1
UniGene Hs.502182
PDB 1B8M
1BND
PDBsum 1B8M
1BND
ProteinModelPortal P23560
SMR P23560
BioGrid 107096
DIP DIP-5719N
IntAct P23560
MINT MINT-1508504
PhosphoSite P23560
DMDM 114900
PaxDb P23560
PRIDE P23560
DNASU 627
Ensembl ENST00000314915
ENST00000356660
ENST00000395978
ENST00000395980
ENST00000395981
ENST00000395983
ENST00000395986
ENST00000418212
ENST00000420794
ENST00000438929
ENST00000439476
ENST00000525528
ENST00000525950
ENST00000530861
ENST00000532997
ENST00000533131
ENST00000533246
GeneID 627
KEGG hsa:627
UCSC uc001mrt.3
uc001mru.3
uc001msa.3
uc009yje.3
uc009yjf.3
CTD 627
GeneCards GC11M027676
H-InvDB HIX0035926
HGNC HGNC:1033
HPA CAB009564
HPA056104
MIM 113505
209880
610269
neXtProt NX_P23560
Orphanet 661
893
PharmGKB PA31891
eggNOG NOG45248
GeneTree ENSGT00390000007725
HOVERGEN HBG006494
InParanoid P23560
KO K04355
OMA RVGWRFI
OrthoDB EOG7RBZ8Z
PhylomeDB P23560
TreeFam TF106463
SignaLink P23560
EvolutionaryTrace P23560
GeneWiki Brain-derived_neurotrophic_factor
GenomeRNAi 627
NextBio 2530
PMAP-CutDB Q6YNR3
PRO PR:P23560
Proteomes UP000005640
Bgee P23560
CleanEx HS_BDNF
ExpressionAtlas P23560
Genevestigator P23560
GO GO:0005737
GO:0030425
GO:0005615
GO:0030061
GO:0043204
GO:0048471
GO:0008021
GO:0043195
GO:0008083
GO:0048675
GO:0007411
GO:0007412
GO:0001662
GO:1990090
GO:0071874
GO:0071356
GO:0002544
GO:0007623
GO:0016358
GO:0097484
GO:0007631
GO:0007214
GO:0014047
GO:0048839
GO:0007612
GO:0042490
GO:0006120
GO:0007406
GO:0043524
GO:0045843
GO:0032229
GO:0021675
GO:0007399
GO:0008038
GO:0048170
GO:0045666
GO:0033138
GO:0051965
GO:0030516
GO:0060079
GO:0046668
GO:0048172
GO:0014823
GO:0072347
GO:0010996
GO:0051602
GO:0014076
GO:0032094
GO:0009725
GO:0055093
GO:0001666
GO:1902065
GO:0009642
GO:0035864
GO:0033189
GO:0061193
GO:0001657
Gene3D 2.10.90.10
InterPro IPR020430
IPR029034
IPR020408
IPR002072
IPR019846
PANTHER PTHR11589
Pfam PF00243
PIRSF PIRSF001789
PRINTS PR01912
PR00268
ProDom PD002052
SMART SM00140
SUPFAM SSF57501
PROSITE PS00248
PS50270

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:2001234

negative regulation of apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21237

P

  • occurs_in:(CL:1001451)
  • regulates_o_occurs_in:(CL:1001451)

Seeded From UniProt

complete

involved_in

GO:0010976

positive regulation of neuron projection development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21237

P

  • occurs_in:(CL:1001451)
  • regulates_o_occurs_in:(CL:1001451)

Seeded From UniProt

complete

involved_in

GO:1900122

positive regulation of receptor binding

PMID:12130635[1]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P46459)

Seeded From UniProt

complete

involved_in

GO:0010832

negative regulation of myotube differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P23363

P

Seeded From UniProt

complete

involved_in

GO:0007416

synapse assembly

PMID:19036963[2]

ECO:0000314

direct assay evidence used in manual assertion

P

part_of:(UBERON:0005372)

Seeded From UniProt

complete

involved_in

GO:0051965

positive regulation of synapse assembly

PMID:19036963[2]

ECO:0000314

direct assay evidence used in manual assertion

P

part_of:(UBERON:0005372)

Seeded From UniProt

complete

involved_in

GO:0048672

positive regulation of collateral sprouting

PMID:19036963[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048668

collateral sprouting

PMID:19036963[2]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0009004)

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21237

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21237

C

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000904283
RGD:619728

P

Seeded From UniProt

complete

involved_in

GO:0048812

neuron projection morphogenesis

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000904283
UniProtKB:P01138

P

Seeded From UniProt

complete

involved_in

GO:0045664

regulation of neuron differentiation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97321
PANTHER:PTN000904283

P

Seeded From UniProt

complete

involved_in

GO:0043524

negative regulation of neuron apoptotic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88145
MGI:MGI:97321
MGI:MGI:97380
PANTHER:PTN000904283
RGD:1598328

P

Seeded From UniProt

complete

involved_in

GO:0038180

nerve growth factor signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97321
PANTHER:PTN000904283

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88145
MGI:MGI:97380
PANTHER:PTN000904283

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88145
PANTHER:PTN000904283
RGD:2202

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88145
PANTHER:PTN000904283
RGD:2202

C

Seeded From UniProt

complete

involved_in

GO:0021675

nerve development

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88145
MGI:MGI:97380
PANTHER:PTN000904283

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000904283
UniProtKB:P20783

F

Seeded From UniProt

complete

part_of

GO:0008021

synaptic vesicle

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000904283
RGD:2202

C

Seeded From UniProt

complete

involved_in

GO:0007613

memory

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000173497
RGD:1598328

P

Seeded From UniProt

complete

involved_in

GO:0007422

peripheral nervous system development

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97321
MGI:MGI:97380
PANTHER:PTN000904283

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000904283
UniProtKB:P20783

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000904283
RGD:1598328
RGD:2202

C

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002072

F

Seeded From UniProt

complete

involved_in

GO:2000008

regulation of protein localization to cell surface

PMID:12130635[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

has_regulation_target:(UniProtKB:P42262)

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

PMID:19036963[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031550

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

PMID:19036963[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031547

brain-derived neurotrophic factor receptor signaling pathway

PMID:19036963[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

PMID:2236018[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:2236018[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903997

positive regulation of non-membrane spanning protein tyrosine kinase activity

Reactome:R-HSA-9032500

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048011

neurotrophin TRK receptor signaling pathway

Reactome:R-HSA-9028731

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007202

activation of phospholipase C activity

Reactome:R-HSA-9026527

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-NUL-9033341
Reactome:R-NUL-9033333
Reactome:R-NUL-9033304
Reactome:R-NUL-9032961
Reactome:R-NUL-9032908
Reactome:R-NUL-9032516
Reactome:R-NUL-9032423
Reactome:R-NUL-9032399
Reactome:R-NUL-9032387
Reactome:R-NUL-9032361
Reactome:R-NUL-9031971
Reactome:R-NUL-9031077
Reactome:R-NUL-9030473
Reactome:R-NUL-9030450
Reactome:R-NUL-9030433
Reactome:R-NUL-9030372
Reactome:R-NUL-9025041
Reactome:R-NUL-9025035
Reactome:R-HSA-9032798
Reactome:R-HSA-9032073
Reactome:R-HSA-9028730
Reactome:R-HSA-9026894

ECO:0000304

author statement supported by traceable reference used in manual assertion






















C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Narisawa-Saito, M et al. (2002) Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons. J. Biol. Chem. 277 40901-10 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Marler, KJ et al. (2008) A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. J. Neurosci. 28 12700-12 PubMed GONUTS page
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Jones, KR & Reichardt, LF (1990) Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc. Natl. Acad. Sci. U.S.A. 87 8060-4 PubMed GONUTS page
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