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HUMAN:BCCIP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) BCCIP (synonyms: TOK1)
Protein Name(s) BRCA2 and CDKN1A-interacting protein

P21- and CDK-associated protein 1 Protein TOK-1

External Links
UniProt Q9P287
EMBL AB040450
AB040451
AY064247
AY064247
AY064248
AY064249
AK055691
AL834458
AL360176
AL360176
AL360176
BC009771
CCDS CCDS7649.1
CCDS7650.1
CCDS7651.1
RefSeq NP_057651.1
NP_510868.1
NP_510869.1
UniGene Hs.370292
Hs.715543
ProteinModelPortal Q9P287
BioGrid 121161
IntAct Q9P287
MINT MINT-3275575
STRING 9606.ENSP00000357748
PhosphoSite Q9P287
DMDM 74753124
MaxQB Q9P287
PaxDb Q9P287
PRIDE Q9P287
DNASU 56647
Ensembl ENST00000278100
ENST00000299130
ENST00000368759
GeneID 56647
KEGG hsa:56647
UCSC uc001ljb.4
uc001ljc.4
uc001ljd.4
CTD 56647
GeneCards GC10P127502
HGNC HGNC:978
HPA HPA056190
MIM 611883
neXtProt NX_Q9P287
PharmGKB PA25290
eggNOG NOG310413
GeneTree ENSGT00390000000696
HOGENOM HOG000047210
HOVERGEN HBG054955
InParanoid Q9P287
KO K15262
OMA MFVNAEE
OrthoDB EOG7992RJ
PhylomeDB Q9P287
TreeFam TF320301
ChiTaRS BCCIP
GeneWiki BCCIP
GenomeRNAi 56647
NextBio 62077
PRO PR:Q9P287
Proteomes UP000005640
Bgee Q9P287
CleanEx HS_BCCIP
ExpressionAtlas Q9P287
Genevestigator Q9P287
GO GO:0019908
GO:0005634
GO:0019207
GO:0044822
GO:0007049
GO:0006281
GO:0061101
GO:0000079
InterPro IPR025602
PANTHER PTHR13261
Pfam PF13862
PIRSF PIRSF028983

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0090307

mitotic spindle assembly

PMID:28394342[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007052

mitotic spindle organization

PMID:28394342[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000226

microtubule cytoskeleton organization

PMID:28394342[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:28394342[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097431

mitotic spindle pole

PMID:28394342[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:28394342[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0034453

microtubule anchoring

PMID:28394342[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061101

neuroendocrine cell differentiation

PMID:18440304[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0097431

mitotic spindle pole

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913415
PANTHER:PTN000327451
UniProtKB:Q9P287

C

Seeded From UniProt

complete

involved_in

GO:0090307

mitotic spindle assembly

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000327451
UniProtKB:Q9P287

P

Seeded From UniProt

complete

involved_in

GO:0034453

microtubule anchoring

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913415
PANTHER:PTN000327451
UniProtKB:Q9P287

P

Seeded From UniProt

complete

enables

GO:0019207

kinase regulator activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000327451
UniProtKB:Q9P287

F

Seeded From UniProt

complete

enables

GO:0015631

tubulin binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000327451
UniProtKB:Q9P287

F

Seeded From UniProt

complete

involved_in

GO:0007052

mitotic spindle organization

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913415
PANTHER:PTN000327451
UniProtKB:Q9P287

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913415
PANTHER:PTN000327451

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913415
PANTHER:PTN000327451
UniProtKB:Q9P287

C

Seeded From UniProt

complete

involved_in

GO:0000132

establishment of mitotic spindle orientation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000327451
UniProtKB:Q9P287

P

Seeded From UniProt

complete

involved_in

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000327451
UniProtKB:Q9P287

P

Seeded From UniProt

complete

part_of

GO:0019908

nuclear cyclin-dependent protein kinase holoenzyme complex

PMID:10878006[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019207

kinase regulator activity

PMID:10878006[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:10878006[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097431

mitotic spindle pole

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CWI3
ensembl:ENSMUSP00000033282

C

Seeded From UniProt

complete

involved_in

GO:0034453

microtubule anchoring

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CWI3
ensembl:ENSMUSP00000033282

P

Seeded From UniProt

complete

involved_in

GO:0007052

mitotic spindle organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CWI3
ensembl:ENSMUSP00000033282

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CWI3
ensembl:ENSMUSP00000033282

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CWI3
ensembl:ENSMUSP00000033282

C

Seeded From UniProt

complete

involved_in

GO:0000226

microtubule cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CWI3
ensembl:ENSMUSP00000033282

P

Seeded From UniProt

complete

enables

GO:0015631

tubulin binding

PMID:28394342[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0097431

mitotic spindle pole

PMID:28394342[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:28394342[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000132

establishment of mitotic spindle orientation

PMID:28394342[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0015631

tubulin binding

PMID:28394342[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0097431

mitotic spindle pole

PMID:28394342[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:28394342[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10878006[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:10878006[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0448

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 Huhn, SC et al. (2017) Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene 36 4750-4766 PubMed GONUTS page
  2. ↑ Ash, SC et al. (2008) LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. Biochem. Biophys. Res. Commun. 371 333-8 PubMed GONUTS page
  3. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Ono, T et al. (2000) TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. J. Biol. Chem. 275 31145-54 PubMed GONUTS page
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