HUMAN:BAP1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BAP1 (synonyms: KIAA0272)
Protein Name(s)	Ubiquitin carboxyl-terminal hydrolase BAP1 BRCA1-associated protein 1 Cerebral protein 6
External Links
UniProt	Q92560
EMBL	AF045581 D88812 D87462 AK292608 CH471055 BC001596 AY130008
CCDS	CCDS2853.1
RefSeq	NP_004647.1
UniGene	Hs.106674
ProteinModelPortal	Q92560
SMR	Q92560
BioGrid	113911
DIP	DIP-47004N
IntAct	Q92560
STRING	9606.ENSP00000417132
BindingDB	Q92560
ChEMBL	CHEMBL1293314
MEROPS	C12.004
iPTMnet	Q92560
PhosphoSite	Q92560
BioMuta	BAP1
DMDM	68565074
MaxQB	Q92560
PaxDb	Q92560
PRIDE	Q92560
Ensembl	ENST00000460680
GeneID	8314
KEGG	hsa:8314
UCSC	uc003ddx.4
CTD	8314
GeneCards	BAP1
HGNC	HGNC:950
HPA	CAB004322 HPA028814 HPA055560
MalaCards	BAP1
MIM	156240 603089 614327
neXtProt	NX_Q92560
Orphanet	289539
PharmGKB	PA25254
eggNOG	KOG2778 ENOG410XP0P
GeneTree	ENSGT00510000046560
HOGENOM	HOG000013189
HOVERGEN	HBG054042
InParanoid	Q92560
KO	K08588
OMA	VRPPQQY
OrthoDB	EOG7GN2M2
PhylomeDB	Q92560
TreeFam	TF313976
BRENDA	3.4.19.12
ChiTaRS	BAP1
GeneWiki	BAP1
GenomeRNAi	8314
NextBio	31137
PRO	PR:Q92560
Proteomes	UP000005640
Bgee	Q92560
CleanEx	HS_BAP1
ExpressionAtlas	Q92560
Genevisible	Q92560
GO	GO:0005737 GO:0005654 GO:0005634 GO:0035517 GO:0003682 GO:0008233 GO:0004843 GO:0006464 GO:0035522 GO:0035520 GO:0008285 GO:1903955 GO:0016579 GO:0071108 GO:0051726 GO:0001558 GO:0006511
Gene3D	3.40.532.10
InterPro	IPR001578
PANTHER	PTHR10589
Pfam	PF01088
PRINTS	PR00707

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0035522	monoubiquitinated histone H2A deubiquitination	PMID:25451922^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035517	PR-DUB complex	PMID:25451922^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:25451922^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903955	positive regulation of protein targeting to mitochondrion	PMID:24270810^[2]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:0071108	protein K48-linked deubiquitination	PMID:19188440^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:19188440^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035522	monoubiquitinated histone H2A deubiquitination	PMID:20436459^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035520	monoubiquitinated protein deubiquitination	PMID:24703950^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035517	PR-DUB complex	PMID:20436459^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	PMID:18757409^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	PMID:19815555^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:9528852^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006464	cellular protein modification process	PMID:9528852^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24703950^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19188440^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18757409^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24703950^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19815555^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19188440^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18757409^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:24703950^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:18757409^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:19815555^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:19188440^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:20436459^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	PMID:19815555^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	PMID:19188440^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	PMID:18757409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	PMID:24703950^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19815555^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001558	regulation of cell growth	PMID:19815555^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010288 FB:FBgn0011327 MGI:MGI:1355274 PANTHER:PTN000063280 UniProtKB:P09936 UniProtKB:P15374 UniProtKB:Q8IIJ6 UniProtKB:Q8IKM8 UniProtKB:Q92560 UniProtKB:Q9Y5K5	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103149 PANTHER:PTN000063280 TAIR:locus:2171312 UniProtKB:P09936 UniProtKB:Q92560	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010288 FB:FBgn0011327 FB:FBgn0262166 MGI:MGI:103149 PANTHER:PTN000063280 PomBase:SPBC409.06 SGD:S000003860 TAIR:locus:2018516 UniProtKB:P09936 UniProtKB:P15374 UniProtKB:Q92560 UniProtKB:Q9Y5K5	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900015	regulation of cytokine production involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99PU7 ensembl:ENSMUSP00000022458	P		Seeded From UniProt	complete
involved_in	GO:0061519	macrophage homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99PU7 ensembl:ENSMUSP00000022458	P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99PU7 ensembl:ENSMUSP00000022458	P		Seeded From UniProt	complete
involved_in	GO:0010035	response to inorganic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99PU7 ensembl:ENSMUSP00000022458	P		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001578 InterPro:IPR036959	F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001578 InterPro:IPR036959	P		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.4.19.12	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:9528852^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9528852^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Reactome:R-HSA-5690790 Reactome:R-HSA-5690759	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5690790 Reactome:R-HSA-5690785 Reactome:R-HSA-5690759 Reactome:R-HSA-5689649 Reactome:R-HSA-5689630	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Okino, Y et al. (2015) BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the ubiquitin-mediated activation of FoxK2 target genes. J. Biol. Chem. 290 1580-91 PubMed GONUTS page
↑ Hasson, SA et al. (2013) High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature 504 291-5 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Misaghi, S et al. (2009) Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1. Mol. Cell. Biol. 29 2181-92 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Scheuermann, JC et al. (2010) Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature 465 243-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Mashtalir, N et al. (2014) Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O. Mol. Cell 54 392-406 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Ventii, KH et al. (2008) BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res. 68 6953-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Machida, YJ et al. (2009) The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1. J. Biol. Chem. 284 34179-88 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Jensen, DE et al. (1998) BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene 16 1097-112 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25451922-1] 1.0 ^1.1 ^1.2 Okino, Y et al. (2015) BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the ubiquitin-mediated activation of FoxK2 target genes. J. Biol. Chem. 290 1580-91 PubMed GONUTS page

[PMID:24270810-2] Hasson, SA et al. (2013) High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature 504 291-5 PubMed GONUTS page

[PMID:19188440-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Misaghi, S et al. (2009) Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1. Mol. Cell. Biol. 29 2181-92 PubMed GONUTS page

[PMID:20436459-4] 4.0 ^4.1 ^4.2 Scheuermann, JC et al. (2010) Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature 465 243-7 PubMed GONUTS page

[PMID:24703950-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Mashtalir, N et al. (2014) Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O. Mol. Cell 54 392-406 PubMed GONUTS page

[PMID:18757409-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Ventii, KH et al. (2008) BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res. 68 6953-62 PubMed GONUTS page

[PMID:19815555-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Machida, YJ et al. (2009) The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1. J. Biol. Chem. 284 34179-88 PubMed GONUTS page

[PMID:9528852-8] 8.0 ^8.1 ^8.2 ^8.3 Jensen, DE et al. (1998) BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene 16 1097-112 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:BAP1

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Annotations

Notes

References

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