HUMAN:BACE1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BACE1 (synonyms: BACE, KIAA1149)
Protein Name(s)	Beta-secretase 1 Aspartyl protease 2 ASP2 Asp 2 Beta-site amyloid precursor protein cleaving enzyme 1 Beta-site APP cleaving enzyme 1 Memapsin-2 Membrane-associated aspartic protease 2
External Links
UniProt	P56817
EMBL	AF190725 AF201468 AF200343 AF204943 AF338816 AF338817 AB050436 AB050437 AB050438 AB032975 DQ007053 EF444940 AP000892 CH471065 BC065492 AF200193
CCDS	CCDS44739.1 CCDS44740.1 CCDS44741.1 CCDS55786.1 CCDS55787.1 CCDS8383.1
PIR	A59090
RefSeq	NP_001193978.1 NP_036236.1 NP_620427.1 NP_620428.1 NP_620429.1
UniGene	Hs.504003
PDB	1FKN 1M4H 1PY1 1SGZ 1TQF 1UJJ 1UJK 1W50 1W51 1XN2 1XN3 1XS7 1YM2 1YM4 2B8L 2B8V 2F3E 2F3F 2FDP 2G94 2HIZ 2HM1 2IQG 2IRZ 2IS0 2NTR 2OAH 2OF0 2OHK 2OHL 2OHM 2OHN 2OHP 2OHQ 2OHR 2OHS 2OHT 2OHU 2P4J 2P83 2P8H 2PH6 2PH8 2Q11 2Q15 2QK5 2QMD 2QMF 2QMG 2QP8 2QU2 2QU3 2QZK 2QZL 2VA5 2VA6 2VA7 2VIE 2VIJ 2VIY 2VIZ 2VJ6 2VJ7 2VJ9 2VKM 2VNM 2VNN 2WEZ 2WF0 2WF1 2WF2 2WF3 2WF4 2WJO 2XFI 2XFJ 2XFK 2ZDZ 2ZE1 2ZHR 2ZHS 2ZHT 2ZHU 2ZHV 2ZJH 2ZJI 2ZJJ 2ZJK 2ZJL 2ZJM 2ZJN 3BRA 3BUF 3BUG 3BUH 3CIB 3CIC 3CID 3CKP 3CKR 3DM6 3DUY 3DV1 3DV5 3EXO 3FKT 3H0B 3HVG 3HW1 3I25 3IGB 3IN3 3IN4 3IND 3INE 3INF 3INH 3IVH 3IVI 3IXJ 3IXK 3K5C 3K5D 3K5F 3K5G 3KMX 3KMY 3KN0 3KYR 3L38 3L3A 3L58 3L59 3L5B 3L5C 3L5D 3L5E 3L5F 3LHG 3LNK 3LPI 3LPJ 3LPK 3MSJ 3MSK 3MSL 3N4L 3NSH 3OHF 3OHH 3OOZ 3PI5 3QBH 3QI1 3R1G 3R2F 3RSV 3RSX 3RTH 3RTM 3RTN 3RU1 3RVI 3S2O 3S7L 3S7M 3SKF 3SKG 3TPJ 3TPL 3TPP 3TPR 3U6A 3UDH 3UDJ 3UDK 3UDM 3UDN 3UDP 3UDQ 3UDR 3UDY 3UFL 3UQP 3UQR 3UQU 3UQW 3UQX 3VEU 3VF3 3VG1 3VV6 3VV7 3VV8 3WB4 3WB5 3ZMG 3ZOV 4ACU 4ACX 4AZY 4B00 4B05 4B0Q 4B1C 4B1D 4B1E 4B70 4B72 4B77 4B78 4BEK 4BFD 4D83 4D85 4D88 4D89 4D8C 4DH6 4DI2 4DJU 4DJV 4DJW 4DJX 4DJY 4DPF 4DPI 4DUS 4DV9 4DVF 4EWO 4EXG 4FCO 4FGX 4FM7 4FM8 4FRI 4FRJ 4FRK 4FRS 4FS4 4FSE 4FSL 4GID 4GMI 4H1E 4H3F 4H3G 4H3I 4H3J 4HA5 4HZT 4I0D 4I0E 4I0F 4I0G 4I0H 4I0I 4I0J 4I0Z 4I10 4I11 4I12 4I1C 4IVS 4IVT 4J0P 4J0T 4J0V 4J0Y 4J0Z 4J17 4J1C 4J1E 4J1F 4J1H 4J1I 4J1K 4JOO 4JP9 4JPC 4JPE 4K8S 4K9H 4KE0 4KE1 4L7G 4L7H 4L7J 4LC7 4LXA 4LXK 4LXM 4N00 4PZW 4PZX 4R8Y 4R91 4R92 4R93 4R95
PDBsum	1FKN 1M4H 1PY1 1SGZ 1TQF 1UJJ 1UJK 1W50 1W51 1XN2 1XN3 1XS7 1YM2 1YM4 2B8L 2B8V 2F3E 2F3F 2FDP 2G94 2HIZ 2HM1 2IQG 2IRZ 2IS0 2NTR 2OAH 2OF0 2OHK 2OHL 2OHM 2OHN 2OHP 2OHQ 2OHR 2OHS 2OHT 2OHU 2P4J 2P83 2P8H 2PH6 2PH8 2Q11 2Q15 2QK5 2QMD 2QMF 2QMG 2QP8 2QU2 2QU3 2QZK 2QZL 2VA5 2VA6 2VA7 2VIE 2VIJ 2VIY 2VIZ 2VJ6 2VJ7 2VJ9 2VKM 2VNM 2VNN 2WEZ 2WF0 2WF1 2WF2 2WF3 2WF4 2WJO 2XFI 2XFJ 2XFK 2ZDZ 2ZE1 2ZHR 2ZHS 2ZHT 2ZHU 2ZHV 2ZJH 2ZJI 2ZJJ 2ZJK 2ZJL 2ZJM 2ZJN 3BRA 3BUF 3BUG 3BUH 3CIB 3CIC 3CID 3CKP 3CKR 3DM6 3DUY 3DV1 3DV5 3EXO 3FKT 3H0B 3HVG 3HW1 3I25 3IGB 3IN3 3IN4 3IND 3INE 3INF 3INH 3IVH 3IVI 3IXJ 3IXK 3K5C 3K5D 3K5F 3K5G 3KMX 3KMY 3KN0 3KYR 3L38 3L3A 3L58 3L59 3L5B 3L5C 3L5D 3L5E 3L5F 3LHG 3LNK 3LPI 3LPJ 3LPK 3MSJ 3MSK 3MSL 3N4L 3NSH 3OHF 3OHH 3OOZ 3PI5 3QBH 3QI1 3R1G 3R2F 3RSV 3RSX 3RTH 3RTM 3RTN 3RU1 3RVI 3S2O 3S7L 3S7M 3SKF 3SKG 3TPJ 3TPL 3TPP 3TPR 3U6A 3UDH 3UDJ 3UDK 3UDM 3UDN 3UDP 3UDQ 3UDR 3UDY 3UFL 3UQP 3UQR 3UQU 3UQW 3UQX 3VEU 3VF3 3VG1 3VV6 3VV7 3VV8 3WB4 3WB5 3ZMG 3ZOV 4ACU 4ACX 4AZY 4B00 4B05 4B0Q 4B1C 4B1D 4B1E 4B70 4B72 4B77 4B78 4BEK 4BFD 4D83 4D85 4D88 4D89 4D8C 4DH6 4DI2 4DJU 4DJV 4DJW 4DJX 4DJY 4DPF 4DPI 4DUS 4DV9 4DVF 4EWO 4EXG 4FCO 4FGX 4FM7 4FM8 4FRI 4FRJ 4FRK 4FRS 4FS4 4FSE 4FSL 4GID 4GMI 4H1E 4H3F 4H3G 4H3I 4H3J 4HA5 4HZT 4I0D 4I0E 4I0F 4I0G 4I0H 4I0I 4I0J 4I0Z 4I10 4I11 4I12 4I1C 4IVS 4IVT 4J0P 4J0T 4J0V 4J0Y 4J0Z 4J17 4J1C 4J1E 4J1F 4J1H 4J1I 4J1K 4JOO 4JP9 4JPC 4JPE 4K8S 4K9H 4KE0 4KE1 4L7G 4L7H 4L7J 4LC7 4LXA 4LXK 4LXM 4N00 4PZW 4PZX 4R8Y 4R91 4R92 4R93 4R95
ProteinModelPortal	P56817
SMR	P56817
BioGrid	117154
DIP	DIP-41388N
IntAct	P56817
MINT	MINT-242532
STRING	9606.ENSP00000318585
BindingDB	P56817
ChEMBL	CHEMBL2111390
GuidetoPHARMACOLOGY	2330
MEROPS	A01.004
TCDB	8.A.32.1.1
PhosphoSite	P56817
DMDM	296434407
PaxDb	P56817
PRIDE	P56817
DNASU	23621
Ensembl	ENST00000313005 ENST00000392937 ENST00000428381 ENST00000445823 ENST00000510630 ENST00000513780
GeneID	23621
KEGG	hsa:23621
UCSC	uc001pqw.3 uc001pqx.3 uc001pqy.3 uc001pqz.3
CTD	23621
GeneCards	GC11M117156
HGNC	HGNC:933
HPA	CAB016358
MIM	604252
neXtProt	NX_P56817
PharmGKB	PA25232
eggNOG	NOG71700
HOVERGEN	HBG059578
InParanoid	P56817
KO	K04521
OMA	YLMSENH
OrthoDB	EOG7DNNVW
PhylomeDB	P56817
TreeFam	TF329595
BioCyc	MetaCyc:ENSG00000160610-MONOMER
BRENDA	3.4.23.46
SABIO-RK	P56817
EvolutionaryTrace	P56817
GeneWiki	Beta-secretase_1
GenomeRNAi	23621
NextBio	35501710
PMAP-CutDB	P56817
PRO	PR:P56817
Proteomes	UP000005640
Bgee	P56817
CleanEx	HS_BACE1
ExpressionAtlas	P56817
Genevestigator	P56817
GO	GO:0030424 GO:0009986 GO:0030659 GO:0005783 GO:0005768 GO:0005794 GO:0016021 GO:0005887 GO:0005770 GO:0005771 GO:0005886 GO:0005802 GO:0004190 GO:0001540 GO:0008798 GO:0019899 GO:0050435 GO:0006509 GO:0006508
Gene3D	2.40.70.10
InterPro	IPR001461 IPR001969 IPR009119 IPR009120 IPR021109
PANTHER	PTHR13683
Pfam	PF00026
PRINTS	PR01816 PR01815 PR00792
SUPFAM	SSF50630
PROSITE	PS00141

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008233	peptidase activity	PMID:22449099^[1]	ECO:0000315			F		Figure 1 shows that the activity of BACE-1 is actively involved in the cleave of ST6Gal I from the Golgi membrane inducing secretion. Mutants without BACE-1 activity could not induce the cleavage of ST6Gal I and no secretion occurred.	complete CACAO 4378
	GO:0008233	peptidase activity	PMID:8562317^[2]	ECO:0000314			F		Figure 3 and Figure 4	complete CACAO 5045
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:24305806^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:23109336^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:23109336^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:23109336^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:23109336^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:23109336^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:27302062^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:27302062^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:27302062^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:27302062^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:16033761^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:16033761^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:10677483^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:10677483^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	PMID:10677483^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:29371969^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	P	occurs_in:(CL:0000031)	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:27084579^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:27084579^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:27084579^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:27084579^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:15886016^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:15886016^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:15886016^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:15886016^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:8562317^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:18353773^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05067)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:16407538^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F	occurs_in:(GO:0005641)	Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	PMID:15080893^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:12586838^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15162	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10531052^[15]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:10531052^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:12586838^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:24612608^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:11466313^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:12586838^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11466313^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:10531052^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	PMID:24612608^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:24612608^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:10531052^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	PMID:10531052^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002299446 RGD:2191 UniProtKB:P56817	P		Seeded From UniProt	complete
involved_in	GO:0030163	protein catabolic process	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000201569 PANTHER:PTN000342793 UniProtKB:P0CY27 UniProtKB:Q5A8N2 UniProtKB:Q5AC08	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 MGI:MGI:1860440 PANTHER:PTN002299446 UniProtKB:P56817 UniProtKB:Q9Y5Z0	C		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002299446 UniProtKB:P56817 UniProtKB:Q9Y5Z0	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000190503 CGD:CAL0000194661 CGD:CAL0000196689 CGD:CAL0000201140 MGI:MGI:1346542 PANTHER:PTN000342793 RGD:621511 SGD:S000002551 TAIR:locus:2008940 UniProtKB:P00797 UniProtKB:P0CY27 UniProtKB:P41748 UniProtKB:P43094 UniProtKB:P56817 UniProtKB:Q59VH7 UniProtKB:Q5AC08 UniProtKB:Q8I6Z5 WB:WBGene00000217	P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 PANTHER:PTN002299446 UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 PANTHER:PTN002299446 RGD:2191 UniProtKB:P56817 UniProtKB:Q9Y5Z0	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 PANTHER:PTN002299446 RGD:2191 UniProtKB:P56817	C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000196689 MGI:MGI:107361 MGI:MGI:1915935 MGI:MGI:88562 PANTHER:PTN000342793 PomBase:SPCC1795.09 RGD:2446 SGD:S000001277 SGD:S000002551 SGD:S000004110 SGD:S000004111 TAIR:locus:2145954 UniProtKB:P00797 UniProtKB:P0CY27 UniProtKB:P14091 UniProtKB:P20142 UniProtKB:P56817 UniProtKB:Q4WNV0 UniProtKB:Q5AC08 UniProtKB:Q8I6Z5 UniProtKB:Q9LTW4 UniProtKB:Q9Y5Z0	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000343246 UniProtKB:P56817	F		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0071287	cellular response to manganese ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	P		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56818 ensembl:ENSMUSP00000034591	F		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001461 InterPro:IPR001969 InterPro:IPR009119 InterPro:IPR009120	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001461 InterPro:IPR001969 InterPro:IPR009119 InterPro:IPR009120	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009119 InterPro:IPR009120	C		Seeded From UniProt	complete
enables	GO:0008798	beta-aspartyl-peptidase activity	PMID:10591214^[19] Reactome:R-HSA-5692495	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10887202^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:12354787^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070931	Golgi-associated vesicle lumen	Reactome:R-HSA-5693092 Reactome:R-HSA-5693086 Reactome:R-HSA-5693081 Reactome:R-HSA-5693071	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	Reactome:R-HSA-5692941 Reactome:R-HSA-5692495	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5693086 Reactome:R-HSA-5692941 Reactome:R-HSA-5692934	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-5693071 Reactome:R-HSA-5693001	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0064	F		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0232	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0152	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lee, M et al. (2012) Cleavage of ST6Gal I by radiation-induced BACE1 inhibits golgi-anchored ST6Gal I-mediated sialylation of integrin β1 and migration in colon cancer cells. Radiat Oncol 7 47 PubMed GONUTS page
↑ ^2.0 ^2.1 Urmoneit, B et al. (1995) Inhibition of beta A4 production by specific modulation of beta-secretase activity. J. Mol. Neurosci. 6 23-32 PubMed GONUTS page
↑ Herskowitz, JH et al. (2013) Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model. J. Neurosci. 33 19086-98 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Kang, EL et al. (2012) BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus. J. Biol. Chem. 287 42867-80 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Yeates, EF & Tesco, G (2016) The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation. J. Biol. Chem. 291 15753-66 PubMed GONUTS page
↑ ^6.0 ^6.1 Koh, YH et al. (2005) BACE is degraded via the lysosomal pathway. J. Biol. Chem. 280 32499-504 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Lin, X et al. (2000) Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 97 1456-60 PubMed GONUTS page
↑ An, F et al. (2017) MiR-124 acts as a target for Alzheimer's disease by regulating BACE1. Oncotarget 8 114065-114071 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Kurkinen, KM et al. (2016) SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J. Cell. Sci. 129 2224-38 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Wahle, T et al. (2005) GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Mol. Cell. Neurosci. 29 453-61 PubMed GONUTS page
↑ Schöbel, S et al. (2008) A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 283 14257-68 PubMed GONUTS page
↑ Spoelgen, R et al. (2006) Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J. Neurosci. 26 418-28 PubMed GONUTS page
↑ Pastorino, L et al. (2004) BACE (beta-secretase) modulates the processing of APLP2 in vivo. Mol. Cell. Neurosci. 25 642-9 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Kametaka, S et al. (2003) Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)). J. Biol. Chem. 278 15239-45 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Vassar, R et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286 735-41 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 John, BA et al. (2014) Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting. FEBS J. 281 2074-87 PubMed GONUTS page
↑ ^17.0 ^17.1 Yan, R et al. (2001) The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate. J. Biol. Chem. 276 36788-96 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 ^18.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Sinha, S et al. (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402 537-40 PubMed GONUTS page
↑ Haniu, M et al. (2000) Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties. J. Biol. Chem. 275 21099-106 PubMed GONUTS page
↑ Hartmann, D et al. (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum. Mol. Genet. 11 2615-24 PubMed GONUTS page

[PMID:22449099-1] Lee, M et al. (2012) Cleavage of ST6Gal I by radiation-induced BACE1 inhibits golgi-anchored ST6Gal I-mediated sialylation of integrin β1 and migration in colon cancer cells. Radiat Oncol 7 47 PubMed GONUTS page

[PMID:8562317-2] 2.0 ^2.1 Urmoneit, B et al. (1995) Inhibition of beta A4 production by specific modulation of beta-secretase activity. J. Mol. Neurosci. 6 23-32 PubMed GONUTS page

[PMID:24305806-3] Herskowitz, JH et al. (2013) Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model. J. Neurosci. 33 19086-98 PubMed GONUTS page

[PMID:23109336-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Kang, EL et al. (2012) BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus. J. Biol. Chem. 287 42867-80 PubMed GONUTS page

[PMID:27302062-5] 5.0 ^5.1 ^5.2 ^5.3 Yeates, EF & Tesco, G (2016) The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation. J. Biol. Chem. 291 15753-66 PubMed GONUTS page

[PMID:16033761-6] 6.0 ^6.1 Koh, YH et al. (2005) BACE is degraded via the lysosomal pathway. J. Biol. Chem. 280 32499-504 PubMed GONUTS page

[PMID:10677483-7] 7.0 ^7.1 ^7.2 Lin, X et al. (2000) Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 97 1456-60 PubMed GONUTS page

[PMID:29371969-8] An, F et al. (2017) MiR-124 acts as a target for Alzheimer's disease by regulating BACE1. Oncotarget 8 114065-114071 PubMed GONUTS page

[PMID:27084579-9] 9.0 ^9.1 ^9.2 ^9.3 Kurkinen, KM et al. (2016) SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J. Cell. Sci. 129 2224-38 PubMed GONUTS page

[PMID:15886016-10] 10.0 ^10.1 ^10.2 ^10.3 Wahle, T et al. (2005) GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Mol. Cell. Neurosci. 29 453-61 PubMed GONUTS page

[PMID:18353773-11] Schöbel, S et al. (2008) A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 283 14257-68 PubMed GONUTS page

[PMID:16407538-12] Spoelgen, R et al. (2006) Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J. Neurosci. 26 418-28 PubMed GONUTS page

[PMID:15080893-13] Pastorino, L et al. (2004) BACE (beta-secretase) modulates the processing of APLP2 in vivo. Mol. Cell. Neurosci. 25 642-9 PubMed GONUTS page

[PMID:12586838-14] 14.0 ^14.1 ^14.2 Kametaka, S et al. (2003) Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)). J. Biol. Chem. 278 15239-45 PubMed GONUTS page

[PMID:10531052-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Vassar, R et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286 735-41 PubMed GONUTS page

[PMID:24612608-16] 16.0 ^16.1 ^16.2 John, BA et al. (2014) Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting. FEBS J. 281 2074-87 PubMed GONUTS page

[PMID:11466313-17] 17.0 ^17.1 Yan, R et al. (2001) The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate. J. Biol. Chem. 276 36788-96 PubMed GONUTS page

[PMID:21873635-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 ^18.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10591214-19] Sinha, S et al. (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402 537-40 PubMed GONUTS page

[PMID:10887202-20] Haniu, M et al. (2000) Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties. J. Biol. Chem. 275 21099-106 PubMed GONUTS page

[PMID:12354787-21] Hartmann, D et al. (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum. Mol. Genet. 11 2615-24 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

HUMAN:BACE1

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

l

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools