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HUMAN:B4DZD6
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Cryptochrome-2 (ECO:0000313 with Ensembl:ENSP00000406751, ECO:0000313 with Ensembl:ENSP00000478187)
cDNA FLJ54895, highly similar to Homo sapiens cryptochrome 2 (photolyase-like) (CRY2), mRNA (ECO:0000313 with EMBL:BAG64048.1) | |
| External Links | ||
| UniProt | B4DZD6 | |
| EMBL | AC068385 KF455380 AK302865 | |
| RefSeq | NP_066940.2 | |
| UniGene | Hs.532491 | |
| DNASU | 1408 | |
| Ensembl | ENST00000443527 ENST00000616623 | |
| GeneID | 1408 | |
| KEGG | hsa:1408 | |
| UCSC | uc010rgn.2 | |
| CTD | 1408 | |
| HGNC | HGNC:2385 | |
| PharmGKB | PA26905 | |
| GeneTree | ENSGT00500000044813 | |
| HOGENOM | HOG000245622 | |
| HOVERGEN | HBG053470 | |
| KO | K02295 | |
| OMA | IQENHDD | |
| OrthoDB | EOG7QG43M | |
| TreeFam | TF323191 | |
| GenomeRNAi | 1408 | |
| NextBio | 5757 | |
| GO | GO:0005737 GO:0005739 GO:0005634 GO:0003913 GO:0071949 GO:0000976 GO:0032922 GO:0006281 GO:0043153 GO:0042593 GO:0019915 GO:0042754 GO:2000323 GO:2000850 GO:0045892 GO:0006606 GO:0032868 | |
| Gene3D | 3.40.50.620 | |
| InterPro | IPR006050 IPR005101 IPR014729 | |
| Pfam | PF00875 PF03441 | |
| SUPFAM | SSF48173 SSF52425 | |
| PROSITE | PS51645 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0014823 |
response to activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009416 |
response to light stimulus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009416 |
response to light stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000323 |
negative regulation of glucocorticoid receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0071949 |
FAD binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043153 |
entrainment of circadian clock by photoperiod |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042754 |
negative regulation of circadian rhythm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042752 |
regulation of circadian rhythm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042593 |
glucose homeostasis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032922 |
circadian regulation of gene expression |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032515 |
negative regulation of phosphoprotein phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P53041) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019902 |
phosphatase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009882 |
blue light photoreceptor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009785 |
blue light signaling pathway |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007623 |
circadian rhythm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0003914 |
DNA (6-4) photolyase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0003904 |
deoxyribodipyrimidine photo-lyase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:0000719 |
photoreactive repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000118 |
regulation of sodium-dependent phosphate transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018298 |
protein-chromophore linkage |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050896 |
response to stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009881 |
photoreceptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Partch, CL et al. (2005) Role of structural plasticity in signal transduction by the cryptochrome blue-light photoreceptor. Biochemistry 44 3795-805 PubMed GONUTS page
- ↑ Kawamoto, T et al. (2004) A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem. Biophys. Res. Commun. 313 117-24 PubMed GONUTS page
- ↑ 3.0 3.1 Honma, S et al. (2002) Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419 841-4 PubMed GONUTS page
- ↑ Hamaguchi, H et al. (2004) Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem. J. 382 43-50 PubMed GONUTS page
- ↑ 5.0 5.1 Zhao, S & Sancar, A (1997) Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity. Photochem. Photobiol. 66 727-31 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Hsu, DS et al. (1996) Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. Biochemistry 35 13871-7 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Ozgur, S & Sancar, A (2003) Purification and properties of human blue-light photoreceptor cryptochrome 2. Biochemistry 42 2926-32 PubMed GONUTS page
- ↑ 8.0 8.1 Ishibashi, K et al. (1998) Molecular cloning of a second human stanniocalcin homologue (STC2). Biochem. Biophys. Res. Commun. 250 252-8 PubMed GONUTS page
c
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- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:2000323 ! negative regulation of glucocorticoid receptor signaling pathway
- GO:0042754 ! negative regulation of circadian rhythm
- GO:0016607 ! nuclear speck
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
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