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HUMAN:B2LA1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | BCL2A1 (synonyms: BCL2L5, BFL1, GRS, HBPA1) | |
| Protein Name(s) | Bcl-2-related protein A1
Bcl-2-like protein 5 Bcl2-L-5 Hemopoietic-specific early response protein Protein BFL-1 Protein GRS | |
| External Links | ||
| UniProt | Q16548 | |
| EMBL | U27467 U29680 Y09397 AY234180 BT007103 CR541937 CR541962 AC015871 CH471136 BC016281 | |
| CCDS | CCDS10312.1 CCDS45322.1 | |
| PIR | I39055 | |
| RefSeq | NP_001108207.1 NP_004040.1 | |
| UniGene | Hs.227817 | |
| PDB | 2VM6 3I1H 3MQP 4ZEQ 5UUK 5UUL 5UUP | |
| PDBsum | 2VM6 3I1H 3MQP 4ZEQ 5UUK 5UUL 5UUP | |
| ProteinModelPortal | Q16548 | |
| SMR | Q16548 | |
| BioGrid | 107069 | |
| IntAct | Q16548 | |
| MINT | MINT-89617 | |
| STRING | 9606.ENSP00000267953 | |
| BindingDB | Q16548 | |
| ChEMBL | CHEMBL6044 | |
| iPTMnet | Q16548 | |
| PhosphoSitePlus | Q16548 | |
| BioMuta | BCL2A1 | |
| DMDM | 2493280 | |
| MaxQB | Q16548 | |
| PaxDb | Q16548 | |
| PeptideAtlas | Q16548 | |
| PRIDE | Q16548 | |
| DNASU | 597 | |
| Ensembl | ENST00000267953 ENST00000335661 | |
| GeneID | 597 | |
| KEGG | hsa:597 | |
| UCSC | uc002bfc.5 | |
| CTD | 597 | |
| DisGeNET | 597 | |
| EuPathDB | HostDB:ENSG00000140379.7 | |
| GeneCards | BCL2A1 | |
| HGNC | HGNC:991 | |
| MIM | 601056 | |
| neXtProt | NX_Q16548 | |
| OpenTargets | ENSG00000140379 | |
| PharmGKB | PA25303 | |
| eggNOG | KOG4728 ENOG41123S0 | |
| GeneTree | ENSGT00510000048456 | |
| HOGENOM | HOG000059278 | |
| HOVERGEN | HBG004840 | |
| InParanoid | Q16548 | |
| KO | K02162 | |
| OMA | ENTAEWI | |
| OrthoDB | EOG091G0N5N | |
| PhylomeDB | Q16548 | |
| TreeFam | TF315834 | |
| SIGNOR | Q16548 | |
| ChiTaRS | BCL2A1 | |
| EvolutionaryTrace | Q16548 | |
| GeneWiki | BCL2-related_protein_A1 | |
| GenomeRNAi | 597 | |
| PRO | PR:Q16548 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000140379 | |
| CleanEx | HS_BCL2A1 | |
| Genevisible | Q16548 | |
| GO | GO:0005741 GO:0015267 GO:0046982 GO:0042803 GO:0097192 GO:0008630 GO:0008053 GO:0043066 GO:0043065 GO:0001836 | |
| Gene3D | 1.10.437.10 | |
| InterPro | IPR002475 IPR020717 IPR020726 IPR013282 IPR036834 IPR026298 | |
| PANTHER | PTHR11256 PTHR11256:SF10 | |
| Pfam | PF00452 | |
| PRINTS | PR01862 PR01867 | |
| SUPFAM | SSF56854 | |
| PROSITE | PS50062 PS01080 PS01258 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000135647 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097192 |
extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101769 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88138 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101769 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1330841 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0029131 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88139 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051400 |
BH domain binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V977 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V977 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021987 |
cerebral cortex development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V977 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007568 |
aging |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V977 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR020717 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Karsan, A et al. (1996) Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. Blood 87 3089-96 PubMed GONUTS page
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