HUMAN:AURKA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AURKA (synonyms: AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6)
Protein Name(s)	Aurora kinase A Aurora 2 Aurora/IPL1-related kinase 1 ARK-1 Aurora-related kinase 1 hARK1 Breast tumor-amplified kinase Serine/threonine-protein kinase 15 Serine/threonine-protein kinase 6 Serine/threonine-protein kinase aurora-A
External Links
UniProt	O14965
EMBL	D84212 AF008551 AF011467 AF011468 AF195947 AF195942 AF195943 AF195944 AF195945 AF195946 AL121914 CH471077 CH471077 CH471077 CH471077 CH471077 CH471077 CH471077 CH471077 CH471077 CH471077 CH471077 CH471077 BC001280 BC002499 BC006423 BC027464
CCDS	CCDS13451.1
PIR	JC5974
RefSeq	NP_003591.2 NP_940835.1 NP_940836.1 NP_940837.1 NP_940838.1 NP_940839.1 XP_005260591.1 XP_006723935.1
UniGene	Hs.250822
PDB	1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 3W10 3W16 3W18 3W2C 4B0G 4BN1 4BYI 4BYJ 4C3P 4C3R 4DEA 4DEB 4DED 4DEE 4DHF 4J8M 4J8N 4JAI 4JAJ 4JBO 4JBP 4JBQ 4PRJ
PDBsum	1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 3W10 3W16 3W18 3W2C 4B0G 4BN1 4BYI 4BYJ 4C3P 4C3R 4DEA 4DEB 4DED 4DEE 4DHF 4J8M 4J8N 4JAI 4JAJ 4JBO 4JBP 4JBQ 4PRJ
ProteinModelPortal	O14965
SMR	O14965
BioGrid	112666
DIP	DIP-33068N
IntAct	O14965
MINT	MINT-254096
STRING	9606.ENSP00000216911
BindingDB	O14965
ChEMBL	CHEMBL4722
GuidetoPHARMACOLOGY	1936
PhosphoSite	O14965
MaxQB	O14965
PaxDb	O14965
PRIDE	O14965
DNASU	6790
Ensembl	ENST00000312783 ENST00000347343 ENST00000371356 ENST00000395911 ENST00000395913 ENST00000395914 ENST00000395915
GeneID	6790
KEGG	hsa:6790
UCSC	uc002xxd.1
CTD	6790
GeneCards	GC20M054944
H-InvDB	HIX0015930
HGNC	HGNC:11393
HPA	CAB001454 HPA002636
MIM	603072
neXtProt	NX_O14965
PharmGKB	PA36201
eggNOG	COG0515
GeneTree	ENSGT00770000120530
HOVERGEN	HBG108519
InParanoid	O14965
KO	K11481
OrthoDB	EOG74FF1F
PhylomeDB	O14965
TreeFam	TF105331
Reactome	REACT_160315 REACT_6761
SignaLink	O14965
EvolutionaryTrace	O14965
GeneWiki	Aurora_A_kinase
GenomeRNAi	6790
NextBio	26512
PRO	PR:O14965
Proteomes	UP000005640
Bgee	O14965
CleanEx	HS_AURKA
ExpressionAtlas	O14965
Genevestigator	O14965
GO	GO:0043203 GO:0005813 GO:0005829 GO:0042585 GO:0072687 GO:0005874 GO:0015630 GO:0030496 GO:0072686 GO:0005634 GO:0048471 GO:0045120 GO:0005819 GO:0031616 GO:0005524 GO:0035174 GO:0004672 GO:0019901 GO:0004674 GO:0004712 GO:0031145 GO:0009948 GO:0051642 GO:0000086 GO:0000278 GO:0007100 GO:0007067 GO:0007052 GO:0043066 GO:0032091 GO:0090233 GO:1990138 GO:0045840 GO:1900195 GO:0032436 GO:0046777 GO:0071539 GO:0006468 GO:0046605 GO:0031647 GO:0007057 GO:0043146
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005813	centrosome	PMID:25657325^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	PMID:25657325^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20460379^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P24522	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:20531406^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031616	spindle pole centrosome	PMID:19801554^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:19801554^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005876	spindle microtubule	PMID:19801554^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20531406^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:19801554^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007051	spindle organization	PMID:21820309^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:21820309^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q86Y91) has_regulation_target:(UniProtKB:Q99661)	Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:15987997^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:18615013^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P53350	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21820309^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q86Y91) has_direct_input:(UniProtKB:Q99661)	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:17726514^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21399614^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:14580337^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024227 PANTHER:PTN000681967 SGD:S000006130 UniProtKB:Q9UQB9 WB:WBGene00000099 dictyBase:DDB_G0279343	C		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107168 MGI:MGI:894678 PANTHER:PTN000681967	F		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681967 SGD:S000006130	P		Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024227 MGI:MGI:107168 PANTHER:PTN000681967 PomBase:SPCC320.13c SGD:S000006130 UniProtKB:Q96GD4 dictyBase:DDB_G0279343	C		Seeded From UniProt	complete
part_of	GO:0031616	spindle pole centrosome	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681967 UniProtKB:O14965 WB:WBGene00000098	C		Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:894678 PANTHER:PTN000681967	P		Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681967 SGD:S000006130 UniProtKB:O14965	C		Seeded From UniProt	complete
part_of	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024227 MGI:MGI:107168 PANTHER:PTN000681967 UniProtKB:Q96GD4	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21807936^[12]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18566290^[13]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:13678582^[14]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	PMID:19435814^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:19435814^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21600873^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21600873^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:21600873^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035404	histone-serine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0035174	P		Seeded From UniProt	complete
involved_in	GO:0035404	histone-serine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035174	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
part_of	GO:0042585	germinal vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	C		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	F		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	F		Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:0007100	mitotic centrosome separation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:0007057	spindle assembly involved in female meiosis I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	F		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:0000212	meiotic spindle organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:1990138	neuron projection extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:1900195	positive regulation of oocyte maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
part_of	GO:0072687	meiotic spindle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	C		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	C		Seeded From UniProt	complete
involved_in	GO:0071539	protein localization to centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:0051642	centrosome localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	P		Seeded From UniProt	complete
part_of	GO:0045120	pronucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	C		Seeded From UniProt	complete
part_of	GO:0043203	axon hillock	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97477 ensembl:ENSMUSP00000028997	C		Seeded From UniProt	complete
involved_in	GO:0000212	meiotic spindle organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030611	P		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030611	P		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030611	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR030611 InterPro:IPR030616	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030611	P		Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030611	P		Seeded From UniProt	complete
involved_in	GO:0007100	mitotic centrosome separation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030611	P		Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030611	P		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:9153231^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9153231^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005819	spindle	PMID:9153231^[17] PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9153231^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046605	regulation of centrosome cycle	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031145	anaphase-promoting complex-dependent catabolic process	Reactome:R-HSA-174178	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	Reactome:R-HSA-8854041 Reactome:R-HSA-8853496	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010389	regulation of G2/M transition of mitotic cell cycle	Reactome:R-HSA-8854518	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Reactome:R-HSA-6791312	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	Reactome:R-HSA-174195	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8854044 Reactome:R-HSA-8854041 Reactome:R-HSA-8853496 Reactome:R-HSA-8853444 Reactome:R-HSA-8853429 Reactome:R-HSA-8853419 Reactome:R-HSA-8853405 Reactome:R-HSA-3000319 Reactome:R-HSA-3000310 Reactome:R-HSA-2574845 Reactome:R-HSA-2574840 Reactome:R-HSA-174195 Reactome:R-HSA-174105 Reactome:R-HSA-174088	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6805103 Reactome:R-HSA-6791235	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-8853419	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	Reactome:R-HSA-69275	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0046	C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ohta, S et al. (2015) CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly. Mol. Biol. Cell 26 1225-37 PubMed GONUTS page
↑ Sánchez, R et al. (2010) Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase. J. Biol. Chem. 285 22196-201 PubMed GONUTS page
↑ ^3.0 ^3.1 Lefebvre, C et al. (2010) A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol. Syst. Biol. 6 377 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Bibby, RA et al. (2009) A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. J. Biol. Chem. 284 33177-84 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Tanenbaum, ME et al. (2011) A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr. Biol. 21 1356-65 PubMed GONUTS page
↑ Yu, CT et al. (2005) Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol. Cell. Biol. 25 5789-800 PubMed GONUTS page
↑ Macůrek, L et al. (2008) Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 455 119-23 PubMed GONUTS page
↑ North, BJ & Verdin, E (2007) Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS ONE 2 e784 PubMed GONUTS page
↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
↑ Bayliss, R et al. (2003) Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol. Cell 12 851-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Johnson, EO et al. (2011) PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer. J. Cell. Sci. 124 2711-22 PubMed GONUTS page
↑ Seki, A et al. (2008) Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science 320 1655-8 PubMed GONUTS page
↑ Hirota, T et al. (2003) Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 114 585-98 PubMed GONUTS page
↑ ^15.0 ^15.1 Li, CC et al. (2009) Aurora-A overexpression in mouse liver causes p53-dependent premitotic arrest during liver regeneration. Mol. Cancer Res. 7 678-88 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Mosquera, J et al. (2011) Identification of Ski as a target for Aurora A kinase. Biochem. Biophys. Res. Commun. 409 539-43 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Kimura, M et al. (1997) Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. J. Biol. Chem. 272 13766-71 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Lukasiewicz, KB & Lingle, WL (2009) Aurora A, centrosome structure, and the centrosome cycle. Environ. Mol. Mutagen. 50 602-19 PubMed GONUTS page

[PMID:25657325-1] 1.0 ^1.1 Ohta, S et al. (2015) CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly. Mol. Biol. Cell 26 1225-37 PubMed GONUTS page

[PMID:20460379-2] Sánchez, R et al. (2010) Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase. J. Biol. Chem. 285 22196-201 PubMed GONUTS page

[PMID:20531406-3] 3.0 ^3.1 Lefebvre, C et al. (2010) A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol. Syst. Biol. 6 377 PubMed GONUTS page

[PMID:19801554-4] 4.0 ^4.1 ^4.2 ^4.3 Bibby, RA et al. (2009) A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. J. Biol. Chem. 284 33177-84 PubMed GONUTS page

[PMID:21820309-5] 5.0 ^5.1 ^5.2 Tanenbaum, ME et al. (2011) A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr. Biol. 21 1356-65 PubMed GONUTS page

[PMID:15987997-6] Yu, CT et al. (2005) Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol. Cell. Biol. 25 5789-800 PubMed GONUTS page

[PMID:18615013-7] Macůrek, L et al. (2008) Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 455 119-23 PubMed GONUTS page

[PMID:17726514-8] North, BJ & Verdin, E (2007) Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS ONE 2 e784 PubMed GONUTS page

[PMID:21399614-9] Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page

[PMID:14580337-10] Bayliss, R et al. (2003) Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol. Cell 12 851-62 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21807936-12] Johnson, EO et al. (2011) PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer. J. Cell. Sci. 124 2711-22 PubMed GONUTS page

[PMID:18566290-13] Seki, A et al. (2008) Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science 320 1655-8 PubMed GONUTS page

[PMID:13678582-14] Hirota, T et al. (2003) Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 114 585-98 PubMed GONUTS page

[PMID:19435814-15] 15.0 ^15.1 Li, CC et al. (2009) Aurora-A overexpression in mouse liver causes p53-dependent premitotic arrest during liver regeneration. Mol. Cancer Res. 7 678-88 PubMed GONUTS page

[PMID:21600873-16] 16.0 ^16.1 ^16.2 Mosquera, J et al. (2011) Identification of Ski as a target for Aurora A kinase. Biochem. Biophys. Res. Commun. 409 539-43 PubMed GONUTS page

[PMID:9153231-17] 17.0 ^17.1 ^17.2 ^17.3 Kimura, M et al. (1997) Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. J. Biol. Chem. 272 13766-71 PubMed GONUTS page

[PMID:19774610-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Lukasiewicz, KB & Lingle, WL (2009) Aurora A, centrosome structure, and the centrosome cycle. Environ. Mol. Mutagen. 50 602-19 PubMed GONUTS page

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