HUMAN:AT2B4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ATP2B4 (synonyms: ATP2B2, MXRA1)
Protein Name(s)	Plasma membrane calcium-transporting ATPase 4 PMCA4 Matrix-remodeling-associated protein 1 Plasma membrane calcium ATPase isoform 4 Plasma membrane calcium pump isoform 4
External Links
UniProt	P23634
EMBL	M25874 M83363 BX537444 U42026 U42061 U42062 U42378 AL513343 AC114402 AL513343 AC114402 CH471067 CH471067 BC140774
CCDS	CCDS1440.1 CCDS30977.1
PIR	A35547
RefSeq	NP_001001396.1 NP_001675.3
UniGene	Hs.343522 Hs.733333
PDB	1CFF 2KNE
PDBsum	1CFF 2KNE
ProteinModelPortal	P23634
SMR	P23634
BioGrid	106983
DIP	DIP-6128N
IntAct	P23634
MINT	MINT-219327
STRING	9606.ENSP00000350310
TCDB	3.A.3.2.1
PhosphoSite	P23634
DMDM	14286105
MaxQB	P23634
PaxDb	P23634
PRIDE	P23634
DNASU	493
Ensembl	ENST00000341360 ENST00000357681 ENST00000367218
GeneID	493
KEGG	hsa:493
UCSC	uc001gzv.3 uc001gzw.3
CTD	493
GeneCards	GC01P203595
HGNC	HGNC:817
HPA	CAB016118 HPA040431
MIM	108732
neXtProt	NX_P23634
PharmGKB	PA25110
eggNOG	COG0474
GeneTree	ENSGT00510000046331
HOVERGEN	HBG061286
InParanoid	P23634
KO	K05850
OMA	EPVMVNA
OrthoDB	EOG7SN8BN
PhylomeDB	P23634
TreeFam	TF300330
Reactome	REACT_23765 REACT_25149
ChiTaRS	ATP2B4
EvolutionaryTrace	P23634
GeneWiki	ATP2B4
GenomeRNAi	493
NextBio	2071
PRO	PR:P23634
Proteomes	UP000005640
Bgee	P23634
CleanEx	HS_ATP2B2 HS_ATP2B4
ExpressionAtlas	P23634
Genevestigator	P23634
GO	GO:0005901 GO:0005887 GO:0016020 GO:0005886 GO:0043234 GO:0030315 GO:0030018 GO:0005524 GO:0005388 GO:0005516 GO:0046872 GO:0050998 GO:0036487 GO:0030346 GO:0097110 GO:0007596 GO:0055074 GO:0098703 GO:0070588 GO:0006874 GO:0071872 GO:0034220 GO:1901205 GO:1900082 GO:0070885 GO:1903243 GO:1903249 GO:0045019 GO:0010751 GO:0051001 GO:1902083 GO:0098736 GO:2000481 GO:0033138 GO:1902305 GO:0006357 GO:0051599 GO:0055085
Gene3D	1.20.1110.10
InterPro	IPR030319 IPR022141 IPR006068 IPR004014 IPR023299 IPR018303 IPR023298 IPR008250 IPR023214 IPR006408 IPR001757
PANTHER	PTHR24093:SF276
Pfam	PF12424 PF00689 PF00690 PF00122 PF00702
PRINTS	PR00119
SMART	SM00831
SUPFAM	SSF56784 SSF81660
TIGRFAMs	TIGR01517 TIGR01494
PROSITE	PS00154

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1902806	regulation of cell cycle G1/S phase transition	PMID:24448801^[1]	ECO:0000315			P		Figure 4. Primary carotid vascular smooth muscle cells (VSMC) from PMCA4 knockout mice showed G1-phase arrest when compared to wild-type plasma membrane calcium ATPase-4 (PMCA4) mice. When electroporated with PMCA4 constructs, knockout PMCA4 mice displayed wild-type phenotype and progressed through G1-phase, whereas mutant mice could not due to having only 10% of normal calcium efflux activity.	complete CACAO 9946
involved_in	GO:1905145	cellular response to acetylcholine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6Q477	P		Seeded From UniProt	complete
involved_in	GO:0014832	urinary bladder smooth muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6Q477	P		Seeded From UniProt	complete
part_of	GO:0036126	sperm flagellum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6Q477	C		Seeded From UniProt	complete
involved_in	GO:0030317	flagellated sperm motility	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6Q477	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6Q477	P		Seeded From UniProt	complete
involved_in	GO:0097553	calcium ion transmembrane import into cytosol	PMID:8530416^[2]	ECO:0000305	curator inference used in manual assertion	GO:0070588	P		Seeded From UniProt	complete
involved_in	GO:1902806	regulation of cell cycle G1/S phase transition	PMID:24448801^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0036487	nitric-oxide synthase inhibitor activity	PMID:17242280^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0098736) part_of:(GO:0086023)	Seeded From UniProt	complete
involved_in	GO:0051001	negative regulation of nitric-oxide synthase activity	PMID:17242280^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0086023) part_of:(GO:0098736)	Seeded From UniProt	complete
involved_in	GO:0071872	cellular response to epinephrine stimulus	PMID:19278978^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002495)\|occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0051001	negative regulation of nitric-oxide synthase activity	PMID:19278978^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	PMID:19278978^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0045019	negative regulation of nitric oxide biosynthetic process	PMID:19278978^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0010751	negative regulation of nitric oxide mediated signal transduction	PMID:19278978^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:19278978^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:1900082	negative regulation of arginine catabolic process	PMID:19278978^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:1903249	negative regulation of citrulline biosynthetic process	PMID:19278978^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098736	negative regulation of the force of heart contraction	PMID:17242280^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:19278978^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:8530416^[2]	ECO:0000305	curator inference used in manual assertion	GO:0070588	P		Seeded From UniProt	complete
involved_in	GO:0051001	negative regulation of nitric-oxide synthase activity	PMID:19287093^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	PMID:19287093^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002495)	Seeded From UniProt	complete
enables	GO:0030346	protein phosphatase 2B binding	PMID:19287093^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	PMID:19287093^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19287093^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051599	response to hydrostatic pressure	PMID:19287093^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	PMID:19287093^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:19287093^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0098703	calcium ion import across plasma membrane	PMID:8530416^[2]	ECO:0000305	curator inference used in manual assertion	GO:0070588	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:8530416^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:8530416^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045019	negative regulation of nitric oxide biosynthetic process	PMID:11591728^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:8530416^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8530416^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0036487	nitric-oxide synthase inhibitor activity	PMID:11591728^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P29475)	Seeded From UniProt	complete
involved_in	GO:0051001	negative regulation of nitric-oxide synthase activity	PMID:11591728^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P29475)	Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	PMID:11591728^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29476	F		Seeded From UniProt	complete
involved_in	GO:0140199	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	PMID:17242280^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902305	regulation of sodium ion transmembrane transport	PMID:18591664^[8]	ECO:0000305	curator inference used in manual assertion	GO:0032991	P		Seeded From UniProt	complete
involved_in	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation	PMID:18591664^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F7AAP4	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F7AAP4	C		Seeded From UniProt	complete
contributes_to	GO:0017080	sodium channel regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F7AAP4	F		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105368 PANTHER:PTN001184751 UniProtKB:P20020 UniProtKB:Q01814 UniProtKB:Q16720	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000643848 RGD:2176 RGD:621303 RGD:621304 RGD:621305 UniProtKB:Q01814	F		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259214 MGI:MGI:105368 MGI:MGI:88111 PANTHER:PTN000643846 PomBase:SPAPB2B4.04c SGD:S000002974 UniProtKB:P23634 UniProtKB:Q4WT17 UniProtKB:Q5B3G0 UniProtKB:Q5BE41 WB:WBGene00003151	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000642960 UniProtKB:P9WPS9	C		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000643812 RGD:2176 RGD:621305 SGD:S000002974 TAIR:locus:2094726 TAIR:locus:2175579 UniProtKB:P23634 UniProtKB:Q01814 WB:WBGene00003151 dictyBase:DDB_G0277861	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:1901660	calcium ion export	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	P		Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	C		Seeded From UniProt	complete
part_of	GO:0097228	sperm principal piece	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	C		Seeded From UniProt	complete
involved_in	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	C		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	F		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	F		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	C		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	P		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	F		Seeded From UniProt	complete
involved_in	GO:0003407	neural retina development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64542 ensembl:ENSRNOP00000004078	P		Seeded From UniProt	complete
involved_in	GO:1905145	cellular response to acetylcholine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6Q477 ensembl:ENSMUSP00000119242	P		Seeded From UniProt	complete
involved_in	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6Q477 ensembl:ENSMUSP00000119242	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6Q477 ensembl:ENSMUSP00000119242	C		Seeded From UniProt	complete
part_of	GO:0036126	sperm flagellum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6Q477 ensembl:ENSMUSP00000119242	C		Seeded From UniProt	complete
involved_in	GO:0030317	flagellated sperm motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6Q477 ensembl:ENSMUSP00000119242	P		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6Q477 ensembl:ENSMUSP00000119242	C		Seeded From UniProt	complete
involved_in	GO:0014832	urinary bladder smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6Q477 ensembl:ENSMUSP00000119242	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6Q477 ensembl:ENSMUSP00000119242	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023299	F		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006408 InterPro:IPR022141 InterPro:IPR034304	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006408 InterPro:IPR034304	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006408	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001757 InterPro:IPR034304	C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006408 InterPro:IPR034304	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:11591728^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2137451^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903779	regulation of cardiac conduction	Reactome:R-HSA-5578775	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	Reactome:R-HSA-936837	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5617178 Reactome:R-HSA-418309	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0282	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Afroze, T et al. (2014) Calcium efflux activity of plasma membrane Ca2+ ATPase-4 (PMCA4) mediates cell cycle progression in vascular smooth muscle cells. J. Biol. Chem. 289 7221-31 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Adamo, HP et al. (1995) Mutants in the putative nucleotide-binding region of the plasma membrane Ca(2+)-pump. A reduction in activity due to slow dephosphorylation. J. Biol. Chem. 270 30111-4 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Oceandy, D et al. (2007) Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b. Circulation 115 483-92 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Mohamed, TM et al. (2009) Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium. J. Biol. Chem. 284 12091-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Wu, X et al. (2009) Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. J. Clin. Invest. 119 976-85 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Schuh, K et al. (2001) The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. J. Cell Biol. 155 201-5 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^8.0 ^8.1 Ueda, K et al. (2008) Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc. Natl. Acad. Sci. U.S.A. 105 9355-60 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Strehler, EE et al. (1990) Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane. J. Biol. Chem. 265 2835-42 PubMed GONUTS page

[PMID:24448801-1] 1.0 ^1.1 Afroze, T et al. (2014) Calcium efflux activity of plasma membrane Ca2+ ATPase-4 (PMCA4) mediates cell cycle progression in vascular smooth muscle cells. J. Biol. Chem. 289 7221-31 PubMed GONUTS page

[PMID:8530416-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Adamo, HP et al. (1995) Mutants in the putative nucleotide-binding region of the plasma membrane Ca(2+)-pump. A reduction in activity due to slow dephosphorylation. J. Biol. Chem. 270 30111-4 PubMed GONUTS page

[PMID:17242280-3] 3.0 ^3.1 ^3.2 ^3.3 Oceandy, D et al. (2007) Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b. Circulation 115 483-92 PubMed GONUTS page

[PMID:19278978-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Mohamed, TM et al. (2009) Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium. J. Biol. Chem. 284 12091-8 PubMed GONUTS page

[PMID:19287093-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Wu, X et al. (2009) Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. J. Clin. Invest. 119 976-85 PubMed GONUTS page

[PMID:11591728-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Schuh, K et al. (2001) The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. J. Cell Biol. 155 201-5 PubMed GONUTS page

[PMID:19946888-7] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:18591664-8] 8.0 ^8.1 Ueda, K et al. (2008) Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc. Natl. Acad. Sci. U.S.A. 105 9355-60 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2137451-10] Strehler, EE et al. (1990) Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane. J. Biol. Chem. 265 2835-42 PubMed GONUTS page

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