HUMAN:ASAH2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ASAH2 (synonyms: HNAC1)
Protein Name(s)	Neutral ceramidase N-CDase NCDase Acylsphingosine deacylase 2 BCDase LCDase hCD N-acylsphingosine amidohydrolase 2 Non-lysosomal ceramidase Neutral ceramidase soluble form
External Links
UniProt	Q9NR71
EMBL	AY049008 AF449759 AL450382 AL589794 AL589794 AL954360 AF250847 BC107105
CCDS	CCDS44398.1 CCDS7239.2
RefSeq	NP_001137446.1 NP_063946.2
UniGene	Hs.512645
ProteinModelPortal	Q9NR71
SMR	Q9NR71
BioGrid	121160 575684
STRING	9606.ENSP00000378897
BindingDB	Q9NR71
ChEMBL	CHEMBL2021754
DMDM	110832757
MaxQB	Q9NR71
PaxDb	Q9NR71
PRIDE	Q9NR71
Ensembl	ENST00000329428 ENST00000395526 ENST00000447815
GeneID	56624
KEGG	hsa:56624
UCSC	uc001jjd.3 uc009xos.3
CTD	56624
GeneCards	GC10M051944
H-InvDB	HIX0058802
HGNC	HGNC:18860
MIM	611202
neXtProt	NX_Q9NR71
PharmGKB	PA134977109
eggNOG	NOG75118
GeneTree	ENSGT00390000015792
HOVERGEN	HBG080870
InParanoid	Q9NR71
KO	K12349
OMA	GAFCESP
OrthoDB	EOG7WQ7RQ
PhylomeDB	Q9NR71
TreeFam	TF300786
BRENDA	3.5.1.23
Reactome	REACT_116105
SABIO-RK	Q9NR71
GeneWiki	ASAH2
GenomeRNAi	56624
NextBio	62071
PRO	PR:Q9NR71
Proteomes	UP000005640
Bgee	Q9NR71
CleanEx	HS_ASAH2
ExpressionAtlas	Q9NR71
Genevestigator	Q9NR71
GO	GO:0016021 GO:0005739 GO:0005886 GO:0017040 GO:0006915 GO:0006672 GO:0006687 GO:0007165 GO:0044281 GO:0006665
InterPro	IPR006823
PANTHER	PTHR12670
Pfam	PF04734

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
colocalizes_with	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91XT9	C	Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JHE3	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JHE3	C	Seeded From UniProt	complete
involved_in	GO:0044241	lipid digestion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JHE3	P	Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	PMID:24798654^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:24798654^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0046514	ceramide catabolic process	PMID:19345744^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	PMID:19345744^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046514	ceramide catabolic process	PMID:30154232^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046512	sphingosine biosynthetic process	PMID:30154232^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017040	N-acylsphingosine amidohydrolase activity	PMID:30154232^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:30154232^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:30154232^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006670	sphingosine metabolic process	PMID:17475390^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046514	ceramide catabolic process	PMID:17475390^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046513	ceramide biosynthetic process	PMID:17475390^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017040	N-acylsphingosine amidohydrolase activity	PMID:17475390^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046514	ceramide catabolic process	PMID:16229686^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006670	sphingosine metabolic process	PMID:16229686^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006670	sphingosine metabolic process	PMID:10781606^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046514	ceramide catabolic process	PMID:10781606^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017040	N-acylsphingosine amidohydrolase activity	PMID:10781606^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:10781606^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:15946935^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006670	sphingosine metabolic process	PMID:15946935^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017040	N-acylsphingosine amidohydrolase activity	PMID:15946935^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046514	ceramide catabolic process	PMID:15946935^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046513	ceramide biosynthetic process	PMID:11278489^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017040	N-acylsphingosine amidohydrolase activity	PMID:11278489^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0017040	N-acylsphingosine amidohydrolase activity	PMID:16229686^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:26190575^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:26190575^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006672	ceramide metabolic process	PMID:26190575^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006670	sphingosine metabolic process	PMID:26190575^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017040	N-acylsphingosine amidohydrolase activity	PMID:26190575^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046514	ceramide catabolic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039774 PANTHER:PTN000975176 UniProtKB:O06769	P	Seeded From UniProt	complete
involved_in	GO:0046512	sphingosine biosynthetic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000975176 UniProtKB:O06769 UniProtKB:Q9I596	P	Seeded From UniProt	complete
involved_in	GO:0042759	long-chain fatty acid biosynthetic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000975176 UniProtKB:O06769 UniProtKB:Q9I596	P	Seeded From UniProt	complete
enables	GO:0017040	N-acylsphingosine amidohydrolase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039774 MGI:MGI:1859310 PANTHER:PTN000975176 UniProtKB:O06769 UniProtKB:Q9I596 UniProtKB:Q9NR71	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039774 PANTHER:PTN000975176	C	Seeded From UniProt	complete
enables	GO:0102121	ceramidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.23	F	Seeded From UniProt	complete
enables	GO:0017040	N-acylsphingosine amidohydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.23	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0006665	sphingolipid metabolic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0746 UniPathway:UPA00222	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C	Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0035	C	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0466	C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhu, Q et al. (2014) Low-dose cytokine-induced neutral ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect. FEBS J. 281 2861-70 PubMed GONUTS page
↑ ^2.0 ^2.1 Wu, BX et al. (2009) Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim. Biophys. Acta 1791 730-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Sakamoto, W et al. (2018) Functions of neutral ceramidase in the Golgi apparatus. J. Lipid Res. 59 2116-2125 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Ohlsson, L et al. (2007) Purification and characterization of human intestinal neutral ceramidase. Biochimie 89 950-60 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Galadari, S et al. (2006) Identification of a novel amidase motif in neutral ceramidase. Biochem. J. 393 687-95 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 El Bawab, S et al. (2000) Molecular cloning and characterization of a human mitochondrial ceramidase. J. Biol. Chem. 275 21508-13 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Osawa, Y et al. (2005) Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J. Biol. Chem. 280 27879-87 PubMed GONUTS page
↑ ^8.0 ^8.1 El Bawab, S et al. (2001) Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J. Biol. Chem. 276 16758-66 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Airola, MV et al. (2015) Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure 23 1482-1491 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24798654-1] 1.0 ^1.1 Zhu, Q et al. (2014) Low-dose cytokine-induced neutral ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect. FEBS J. 281 2861-70 PubMed GONUTS page

[PMID:19345744-2] 2.0 ^2.1 Wu, BX et al. (2009) Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim. Biophys. Acta 1791 730-9 PubMed GONUTS page

[PMID:30154232-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Sakamoto, W et al. (2018) Functions of neutral ceramidase in the Golgi apparatus. J. Lipid Res. 59 2116-2125 PubMed GONUTS page

[PMID:17475390-4] 4.0 ^4.1 ^4.2 ^4.3 Ohlsson, L et al. (2007) Purification and characterization of human intestinal neutral ceramidase. Biochimie 89 950-60 PubMed GONUTS page

[PMID:16229686-5] 5.0 ^5.1 ^5.2 Galadari, S et al. (2006) Identification of a novel amidase motif in neutral ceramidase. Biochem. J. 393 687-95 PubMed GONUTS page

[PMID:10781606-6] 6.0 ^6.1 ^6.2 ^6.3 El Bawab, S et al. (2000) Molecular cloning and characterization of a human mitochondrial ceramidase. J. Biol. Chem. 275 21508-13 PubMed GONUTS page

[PMID:15946935-7] 7.0 ^7.1 ^7.2 ^7.3 Osawa, Y et al. (2005) Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J. Biol. Chem. 280 27879-87 PubMed GONUTS page

[PMID:11278489-8] 8.0 ^8.1 El Bawab, S et al. (2001) Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J. Biol. Chem. 276 16758-66 PubMed GONUTS page

[PMID:26190575-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Airola, MV et al. (2015) Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure 23 1482-1491 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:ASAH2

Contents

Annotations

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References

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