HUMAN:APOC3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	APOC3
Protein Name(s)	Apolipoprotein C-III Apo-CIII ApoC-III Apolipoprotein C3
External Links
UniProt	P02656
EMBL	J00098 M33043 M33041 M33042 X01392 X01388 X03120 V01513 M28613 M28614 X00567 AY422951 AY555191 BC027977 BC121081
CCDS	CCDS8377.1
PIR	A90950
RefSeq	NP_000031.1
UniGene	Hs.73849
PDB	2JQ3
PDBsum	2JQ3
ProteinModelPortal	P02656
SMR	P02656
BioGrid	106842
IntAct	P02656
MINT	MINT-5000873
STRING	9606.ENSP00000227667
PhosphoSite	P02656
UniCarbKB	P02656
BioMuta	APOC3
DMDM	114026
DOSAC-COBS-2DPAGE	P02656
SWISS-2DPAGE	P02656
MaxQB	P02656
PaxDb	P02656
PRIDE	P02656
DNASU	345
Ensembl	ENST00000227667
GeneID	345
KEGG	hsa:345
UCSC	uc001ppt.1
CTD	345
GeneCards	GC11P116700
HGNC	HGNC:610
MIM	107720 614028
neXtProt	NX_P02656
Orphanet	79506 33271
PharmGKB	PA53
eggNOG	NOG39866
GeneTree	ENSGT00390000015395
HOGENOM	HOG000247042
HOVERGEN	HBG050549
InParanoid	P02656
KO	K08759
PhylomeDB	P02656
TreeFam	TF338209
Reactome	REACT_13621 REACT_24968 REACT_6841
EvolutionaryTrace	P02656
GeneWiki	Apolipoprotein_C3
GenomeRNAi	345
NextBio	1423
PRO	PR:P02656
Proteomes	UP000005640
Bgee	P02656
CleanEx	HS_APOC3
ExpressionAtlas	P02656
Genevisible	P02656
GO	GO:0042627 GO:0005769 GO:0070062 GO:0005576 GO:0005615 GO:0034363 GO:0034366 GO:0034361 GO:0015485 GO:0030234 GO:0070653 GO:0055102 GO:0005543 GO:0033344 GO:0042632 GO:0034382 GO:0007186 GO:0034375 GO:0042157 GO:0060621 GO:0045717 GO:0010987 GO:0050995 GO:0045833 GO:0051005 GO:0010989 GO:0048261 GO:0010897 GO:0010916 GO:0010903 GO:0033700 GO:0007603 GO:0032489 GO:0001523 GO:0043691 GO:0044281 GO:0019433 GO:0070328 GO:0006641 GO:0034379
InterPro	IPR008403
PANTHER	PTHR14225
Pfam	PF05778
ProDom	PD010414

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27559042^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0006618) part_of:(UBERON:0002302)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27068509^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070653	high-density lipoprotein particle receptor binding	PMID:9254056^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61009	F		Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	PMID:18767813^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060621	negative regulation of cholesterol import	PMID:15778093^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0055102	lipase inhibitor activity	PMID:3973011^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0055102	lipase inhibitor activity	PMID:18635818^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0055102	lipase inhibitor activity	PMID:15576844^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0055102	lipase inhibitor activity	PMID:182536^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051005	negative regulation of lipoprotein lipase activity	PMID:3973011^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051005	negative regulation of lipoprotein lipase activity	PMID:18635818^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051005	negative regulation of lipoprotein lipase activity	PMID:11060345^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	PMID:15576844^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048261	negative regulation of receptor-mediated endocytosis	PMID:1917954^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045833	negative regulation of lipid metabolic process	PMID:182536^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045717	negative regulation of fatty acid biosynthetic process	PMID:18635818^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045717	negative regulation of fatty acid biosynthetic process	PMID:11060345^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043691	reverse cholesterol transport	PMID:17438339^[13]	ECO:0000305	curator inference used in manual assertion	GO:0034375	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:18767813^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	PMID:8245722^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034382	chylomicron remnant clearance	PMID:4020294^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:17438339^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034366	spherical high-density lipoprotein particle	PMID:17438339^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	PMID:17336988^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:17154273^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:3973011^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:16935699^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:11162594^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:11162594^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:16443932^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032489	regulation of Cdc42 protein signal transduction	PMID:16443932^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030234	enzyme regulator activity	PMID:11060345^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:11060345^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:11162594^[19]	ECO:0000305	curator inference used in manual assertion	GO:0033344	F		Seeded From UniProt	complete
involved_in	GO:0010989	negative regulation of low-density lipoprotein particle clearance	PMID:15778093^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010987	negative regulation of high-density lipoprotein particle clearance	PMID:15778093^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	PMID:1917954^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	PMID:3973011^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	PMID:18635818^[8]	ECO:0000305	curator inference used in manual assertion	GO:0051005	P		Seeded From UniProt	complete
involved_in	GO:0010897	negative regulation of triglyceride catabolic process	PMID:3973011^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010897	negative regulation of triglyceride catabolic process	PMID:18635818^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:16443932^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11060345^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:11060345^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:4066713^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006641	triglyceride metabolic process	PMID:17142127^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070653	high-density lipoprotein particle receptor binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	F		Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	P		Seeded From UniProt	complete
enables	GO:0055102	lipase inhibitor activity	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	F		Seeded From UniProt	complete
involved_in	GO:0051005	negative regulation of lipoprotein lipase activity	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	P		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	C		Seeded From UniProt	complete
part_of	GO:0034366	spherical high-density lipoprotein particle	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	C		Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	C		Seeded From UniProt	complete
involved_in	GO:0010989	negative regulation of low-density lipoprotein particle clearance	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	P		Seeded From UniProt	complete
involved_in	GO:0010987	negative regulation of high-density lipoprotein particle clearance	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	P		Seeded From UniProt	complete
involved_in	GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	P		Seeded From UniProt	complete
involved_in	GO:0010897	negative regulation of triglyceride catabolic process	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	P		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000369187 UniProtKB:P02656	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008403	C		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008403	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008403	F		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008403	P		Seeded From UniProt	complete
involved_in	GO:0034379	very-low-density lipoprotein particle assembly	PMID:18399797^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034378	chylomicron assembly	Reactome:R-HSA-8963888	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	Reactome:R-HSA-8964058	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034371	chylomicron remodeling	Reactome:R-HSA-8963901	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	Reactome:R-HSA-2429643 Reactome:R-HSA-2404140 Reactome:R-HSA-2404131	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-266303 Reactome:R-HSA-2423785 Reactome:R-HSA-2404131 Reactome:R-HSA-2395784 Reactome:R-HSA-2395768 Reactome:R-HSA-174757 Reactome:R-HSA-174690 Reactome:R-HSA-174660	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001523	retinoid metabolic process	Reactome:R-HSA-975634	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0442	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0162	C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0850	C		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Xu, S et al. (1997) Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake. J. Lipid Res. 38 1289-98 PubMed GONUTS page
↑ ^5.0 ^5.1 Kypreos, KE (2008) ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia. Biochemistry 47 10491-502 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Huard, K et al. (2005) Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells. Int. J. Biochem. Cell Biol. 37 1308-18 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Wang, CS et al. (1985) Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III. J. Clin. Invest. 75 384-90 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Dorfmeister, B et al. (2008) Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. Arterioscler. Thromb. Vasc. Biol. 28 1866-71 PubMed GONUTS page
↑ ^9.0 ^9.1 Berbée, JF et al. (2005) Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL. J. Lipid Res. 46 297-306 PubMed GONUTS page
↑ ^10.0 ^10.1 Kinnunen, PK & Ehnolm, C (1976) Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase. FEBS Lett. 65 354-7 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Liu, H et al. (2000) Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr. J. Lipid Res. 41 1760-71 PubMed GONUTS page
↑ ^12.0 ^12.1 Sehayek, E & Eisenberg, S (1991) Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J. Biol. Chem. 266 18259-67 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Qu, S et al. (2007) Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice. J. Lipid Res. 48 1476-87 PubMed GONUTS page
↑ Connelly, PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J. Lipid Res. 34 1717-27 PubMed GONUTS page
↑ Windler, E & Havel, RJ (1985) Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J. Lipid Res. 26 556-65 PubMed GONUTS page
↑ Meyer, BJ et al. (2007) Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate. Atherosclerosis 195 e28-34 PubMed GONUTS page
↑ Mancone, C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7 143-54 PubMed GONUTS page
↑ Jackson, KG et al. (2006) Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids. Nutr Metab Cardiovasc Dis 16 405-17 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Nofer, JR et al. (2006) Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J. Lipid Res. 47 794-803 PubMed GONUTS page
↑ Yokoyama, S et al. (1985) Behavior of human apolipoprotein E in aqueous solutions and at interfaces. J. Biol. Chem. 260 16375-82 PubMed GONUTS page
↑ Hallman, DM et al. (2006) Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study. Metab. Clin. Exp. 55 1574-81 PubMed GONUTS page
↑ ^23.00 ^23.01 ^23.02 ^23.03 ^23.04 ^23.05 ^23.06 ^23.07 ^23.08 ^23.09 ^23.10 ^23.11 ^23.12 ^23.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ooi, EM et al. (2008) Apolipoprotein C-III: understanding an emerging cardiovascular risk factor. Clin. Sci. 114 611-24 PubMed GONUTS page

[PMID:27559042-1] Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page

[PMID:27068509-2] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:23533145-3] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:9254056-4] Xu, S et al. (1997) Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake. J. Lipid Res. 38 1289-98 PubMed GONUTS page

[PMID:18767813-5] 5.0 ^5.1 Kypreos, KE (2008) ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia. Biochemistry 47 10491-502 PubMed GONUTS page

[PMID:15778093-6] 6.0 ^6.1 ^6.2 Huard, K et al. (2005) Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells. Int. J. Biochem. Cell Biol. 37 1308-18 PubMed GONUTS page

[PMID:3973011-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Wang, CS et al. (1985) Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III. J. Clin. Invest. 75 384-90 PubMed GONUTS page

[PMID:18635818-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Dorfmeister, B et al. (2008) Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. Arterioscler. Thromb. Vasc. Biol. 28 1866-71 PubMed GONUTS page

[PMID:15576844-9] 9.0 ^9.1 Berbée, JF et al. (2005) Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL. J. Lipid Res. 46 297-306 PubMed GONUTS page

[PMID:182536-10] 10.0 ^10.1 Kinnunen, PK & Ehnolm, C (1976) Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase. FEBS Lett. 65 354-7 PubMed GONUTS page

[PMID:11060345-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Liu, H et al. (2000) Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr. J. Lipid Res. 41 1760-71 PubMed GONUTS page

[PMID:1917954-12] 12.0 ^12.1 Sehayek, E & Eisenberg, S (1991) Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J. Biol. Chem. 266 18259-67 PubMed GONUTS page

[PMID:17438339-13] 13.0 ^13.1 ^13.2 Qu, S et al. (2007) Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice. J. Lipid Res. 48 1476-87 PubMed GONUTS page

[PMID:8245722-14] Connelly, PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J. Lipid Res. 34 1717-27 PubMed GONUTS page

[PMID:4020294-15] Windler, E & Havel, RJ (1985) Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J. Lipid Res. 26 556-65 PubMed GONUTS page

[PMID:17336988-16] Meyer, BJ et al. (2007) Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate. Atherosclerosis 195 e28-34 PubMed GONUTS page

[PMID:17154273-17] Mancone, C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7 143-54 PubMed GONUTS page

[PMID:16935699-18] Jackson, KG et al. (2006) Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids. Nutr Metab Cardiovasc Dis 16 405-17 PubMed GONUTS page

[PMID:11162594-19] 19.0 ^19.1 ^19.2 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page

[PMID:16443932-20] 20.0 ^20.1 ^20.2 Nofer, JR et al. (2006) Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J. Lipid Res. 47 794-803 PubMed GONUTS page

[PMID:4066713-21] Yokoyama, S et al. (1985) Behavior of human apolipoprotein E in aqueous solutions and at interfaces. J. Biol. Chem. 260 16375-82 PubMed GONUTS page

[PMID:17142127-22] Hallman, DM et al. (2006) Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study. Metab. Clin. Exp. 55 1574-81 PubMed GONUTS page

[PMID:21873635-23] 23.00 ^23.01 ^23.02 ^23.03 ^23.04 ^23.05 ^23.06 ^23.07 ^23.08 ^23.09 ^23.10 ^23.11 ^23.12 ^23.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18399797-24] Ooi, EM et al. (2008) Apolipoprotein C-III: understanding an emerging cardiovascular risk factor. Clin. Sci. 114 611-24 PubMed GONUTS page

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HUMAN:APOC3

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