HUMAN:APOA2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	APOA2
Protein Name(s)	Apolipoprotein A-II Apo-AII ApoA-II Apolipoprotein A2 Proapolipoprotein A-II ProapoA-II Truncated apolipoprotein A-II Apolipoprotein A-II(1-76)
External Links
UniProt	P02652
EMBL	X04898 X00955 X02905 X02619 M29882 AY100524 AK312034 BT006786 AL590714 BC005282
CCDS	CCDS1226.1
PIR	A93586
RefSeq	NP_001634.1
UniGene	Hs.237658
PDB	1L6L 2OU1
PDBsum	1L6L 2OU1
ProteinModelPortal	P02652
BioGrid	106833
IntAct	P02652
MINT	MINT-106326
STRING	9606.ENSP00000356969
PhosphoSite	P02652
BioMuta	APOA2
DMDM	114000
SWISS-2DPAGE	P02652
MaxQB	P02652
PaxDb	P02652
PeptideAtlas	P02652
PRIDE	P02652
DNASU	336
Ensembl	ENST00000367990
GeneID	336
KEGG	hsa:336
UCSC	uc001fzc.1
CTD	336
GeneCards	GC01M161192
HGNC	HGNC:601
HPA	CAB025885
MIM	107670
neXtProt	NX_P02652
Orphanet	238269
PharmGKB	PA24886
eggNOG	NOG40617
GeneTree	ENSGT00390000003306
HOGENOM	HOG000033999
HOVERGEN	HBG050544
InParanoid	P02652
KO	K08758
OrthoDB	EOG7G4QHG
PhylomeDB	P02652
TreeFam	TF338165
Reactome	REACT_116145 REACT_24968 REACT_6841
ChiTaRS	APOA2
EvolutionaryTrace	P02652
GeneWiki	APOA2
GenomeRNAi	336
NextBio	1391
PMAP-CutDB	P02652
PRO	PR:P02652
Proteomes	UP000005640
Bgee	P02652
CleanEx	HS_APOA2
ExpressionAtlas	P02652
Genevisible	P02652
GO	GO:0072562 GO:0042627 GO:0005829 GO:0005769 GO:0005788 GO:0070062 GO:0005576 GO:0034364 GO:0034366 GO:0034361 GO:0034190 GO:0015485 GO:0017127 GO:0008035 GO:0070653 GO:0055102 GO:0008289 GO:0005319 GO:0031210 GO:0060228 GO:0005543 GO:0046982 GO:0042803 GO:0002526 GO:0044255 GO:0033344 GO:0042632 GO:0008203 GO:0046340 GO:0034380 GO:0034384 GO:0034375 GO:0042157 GO:0034374 GO:0060621 GO:0032375 GO:0060695 GO:0002740 GO:0060192 GO:0050995 GO:0010903 GO:0031100 GO:0018206 GO:0006656 GO:0009395 GO:0033700 GO:0007603 GO:0043085 GO:0010873 GO:0045416 GO:0050996 GO:0006457 GO:0018158 GO:0030300 GO:0031647 GO:0042493 GO:0043627 GO:0051384 GO:0009749 GO:0001523 GO:0043691 GO:0044281 GO:0006641 GO:0034370 GO:0016032
InterPro	IPR006801
PANTHER	PTHR11027
Pfam	PF04711
ProDom	PD010397

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0050821	protein stabilization	PMID:20495215^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:27477018^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NZC2	F	happens_during:(GO:0006497)	Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	PMID:20495215^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	PMID:11027668^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10809	F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
enables	GO:0070653	high-density lipoprotein particle receptor binding	PMID:10764676^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8WTV0	F		Seeded From UniProt	complete
involved_in	GO:0060695	negative regulation of cholesterol transporter activity	PMID:8106353^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060621	negative regulation of cholesterol import	PMID:10764676^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060192	negative regulation of lipase activity	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0055102	lipase inhibitor activity	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050996	positive regulation of lipid catabolic process	PMID:8640403^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:8245722^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04114	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:8245722^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	F		Seeded From UniProt	complete
involved_in	GO:0046340	diacylglycerol catabolic process	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043691	reverse cholesterol transport	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17264082^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	PMID:8245722^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034384	high-density lipoprotein particle clearance	PMID:10764676^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:218942^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:8106353^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034374	low-density lipoprotein particle remodeling	PMID:8106353^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034370	triglyceride-rich lipoprotein particle remodeling	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034366	spherical high-density lipoprotein particle	PMID:16682745^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:210174^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:3104518^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:17264082^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:8245722^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0034190	apolipoprotein receptor binding	PMID:11162594^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95477	F		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:11162594^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:11162594^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032375	negative regulation of cholesterol transport	PMID:8636092^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P02647)	Seeded From UniProt	complete
enables	GO:0031210	phosphatidylcholine binding	PMID:17264082^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0017127	cholesterol transporter activity	PMID:9651324^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:218942^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010873	positive regulation of cholesterol esterification	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	PMID:14988251^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009395	phospholipid catabolic process	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006656	phosphatidylcholine biosynthetic process	PMID:14967812^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:218942^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005319	lipid transporter activity	PMID:1606170^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002740	negative regulation of cytokine secretion involved in immune response	PMID:12458630^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7918467^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05090	F		Seeded From UniProt	complete
involved_in	GO:0045416	positive regulation of interleukin-8 biosynthetic process	PMID:11591715^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018206	peptidyl-methionine modification	PMID:12576517^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018158	protein oxidation	PMID:12576517^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:14718574^[27]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070653	high-density lipoprotein particle receptor binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	F		Seeded From UniProt	complete
involved_in	GO:0060192	negative regulation of lipase activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88050 PANTHER:PTN000111938 UniProtKB:P02652	P		Seeded From UniProt	complete
enables	GO:0055102	lipase inhibitor activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	F		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88050 PANTHER:PTN000111938 UniProtKB:P02652	P		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	C		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88050 PANTHER:PTN000111938	P		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	P		Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	P		Seeded From UniProt	complete
involved_in	GO:0034374	low-density lipoprotein particle remodeling	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	P		Seeded From UniProt	complete
involved_in	GO:0034370	triglyceride-rich lipoprotein particle remodeling	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	P		Seeded From UniProt	complete
part_of	GO:0034366	spherical high-density lipoprotein particle	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	C		Seeded From UniProt	complete
enables	GO:0034190	apolipoprotein receptor binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	F		Seeded From UniProt	complete
enables	GO:0031210	phosphatidylcholine binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	F		Seeded From UniProt	complete
involved_in	GO:0030301	cholesterol transport	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 RGD:2131	P		Seeded From UniProt	complete
contributes_to	GO:0017127	cholesterol transporter activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 RGD:2131 UniProtKB:P02652	F		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111938 UniProtKB:P02652	F		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88050 PANTHER:PTN000111938	P		Seeded From UniProt	complete
enables	GO:0008035	high-density lipoprotein particle binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88050 PANTHER:PTN000111938	F		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060228	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04638 ensembl:ENSRNOP00000004662	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04638 ensembl:ENSRNOP00000004662	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04638 ensembl:ENSRNOP00000004662	P		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04638 ensembl:ENSRNOP00000004662	P		Seeded From UniProt	complete
involved_in	GO:0030301	cholesterol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04638 ensembl:ENSRNOP00000004662	P		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04638 ensembl:ENSRNOP00000004662	F		Seeded From UniProt	complete
involved_in	GO:0002526	acute inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04638 ensembl:ENSRNOP00000004662	P		Seeded From UniProt	complete
involved_in	GO:0060192	negative regulation of lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09813 ensembl:ENSMUSP00000106953	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09813 ensembl:ENSMUSP00000106953	P		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09813 ensembl:ENSMUSP00000106953	P		Seeded From UniProt	complete
involved_in	GO:0030300	regulation of intestinal cholesterol absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09813 ensembl:ENSMUSP00000106953	P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09813 ensembl:ENSMUSP00000106953	P		Seeded From UniProt	complete
enables	GO:0008035	high-density lipoprotein particle binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09813 ensembl:ENSMUSP00000106953	F		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09813 ensembl:ENSMUSP00000106953	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09813 ensembl:ENSMUSP00000106953	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006801 InterPro:IPR036172	C		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006801 InterPro:IPR036172	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006801 InterPro:IPR036172	F		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006801 InterPro:IPR036172	P		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:27477018^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006641	triglyceride metabolic process	PMID:11551871^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-2395784 Reactome:R-HSA-2395768 Reactome:R-HSA-2187332 Reactome:R-HSA-1989776 Reactome:R-HSA-174757 Reactome:R-HSA-174690 Reactome:R-HSA-174660 Reactome:R-HSA-174587 Reactome:R-HSA-2423785 Reactome:R-HSA-2404131	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001523	retinoid metabolic process	Reactome:R-HSA-975634	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034378	chylomicron assembly	Reactome:R-HSA-8963888	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034371	chylomicron remodeling	Reactome:R-HSA-8963901	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	Reactome:R-HSA-400206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-2395764 Reactome:R-HSA-2187332	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289 Reactome:R-HSA-174741 Reactome:R-HSA-174587	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	Reactome:R-HSA-2429643 Reactome:R-HSA-2404140 Reactome:R-HSA-2404131	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0345	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Tanaka, N et al. (2010) Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. J. Lipid Res. 51 2591-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Yeh, FL et al. (2016) TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron 91 328-40 PubMed GONUTS page
↑ Bocharov, AV et al. (2000) Heat shock protein 60 is a high-affinity high-density lipoprotein binding protein. Biochem. Biophys. Res. Commun. 277 228-35 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Pilon, A et al. (2000) Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake. Arterioscler. Thromb. Vasc. Biol. 20 1074-81 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Lagrost, L et al. (1994) Influence of apolipoprotein composition of high density lipoprotein particles on cholesteryl ester transfer protein activity. Particles containing various proportions of apolipoproteins AI and AII. J. Biol. Chem. 269 3189-97 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 Boucher, J et al. (2004) Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. J. Lipid Res. 45 849-58 PubMed GONUTS page
↑ Mowri, HO et al. (1996) Apolipoprotein A-II influences the substrate properties of human HDL2 and HDL3 for hepatic lipase. Arterioscler. Thromb. Vasc. Biol. 16 755-62 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Connelly, PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J. Lipid Res. 34 1717-27 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Silva, RA et al. (2007) The structure of apolipoprotein A-II in discoidal high density lipoproteins. J. Biol. Chem. 282 9713-21 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Ritter, MC & Scanu, AM (1979) Apolipoprotein A-II and structure of human serum high density lipoproteins. An approach by reassembly techniques. J. Biol. Chem. 254 2517-25 PubMed GONUTS page
↑ Christoffersen, C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J. Lipid Res. 47 1833-43 PubMed GONUTS page
↑ Weisgraber, KH & Mahley, RW (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J. Biol. Chem. 253 6281-8 PubMed GONUTS page
↑ Cheung, MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J. Lipid Res. 27 1135-44 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page
↑ Marzal-Casacuberta, A et al. (1996) Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II. J. Biol. Chem. 271 6720-8 PubMed GONUTS page
↑ Wang, WQ et al. (1998) Enhanced cholesterol efflux by tyrosyl radical-oxidized high density lipoprotein is mediated by apolipoprotein AI-AII heterodimers. J. Biol. Chem. 273 17391-8 PubMed GONUTS page
↑ Sauvaget, D et al. (2004) In vitro transcriptional induction of the human apolipoprotein A-II gene by glucose. Diabetes 53 672-8 PubMed GONUTS page
↑ Bekaert, ED et al. (1992) Isolation and partial characterization of lipoprotein A-II (LP-A-II) particles of human plasma. Biochim. Biophys. Acta 1126 105-13 PubMed GONUTS page
↑ Furlaneto, CJ et al. (2002) Apolipoproteins A-I and A-II downregulate neutrophil functions. Lipids 37 925-8 PubMed GONUTS page
↑ Yang, CY et al. (1994) Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links. Biochemistry 33 12451-5 PubMed GONUTS page
↑ Klezovitch, O et al. (2001) Stimulation of interleukin-8 production in human THP-1 macrophages by apolipoprotein(a). Evidence for a critical involvement of elements in its C-terminal domain. J. Biol. Chem. 276 46864-9 PubMed GONUTS page
↑ ^26.0 ^26.1 Pankhurst, G et al. (2003) Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein. J. Lipid Res. 44 349-55 PubMed GONUTS page
↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
↑ ^28.00 ^28.01 ^28.02 ^28.03 ^28.04 ^28.05 ^28.06 ^28.07 ^28.08 ^28.09 ^28.10 ^28.11 ^28.12 ^28.13 ^28.14 ^28.15 ^28.16 ^28.17 ^28.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ van 't Hooft, FM et al. (2001) Human evidence that the apolipoprotein a-II gene is implicated in visceral fat accumulation and metabolism of triglyceride-rich lipoproteins. Circulation 104 1223-8 PubMed GONUTS page

[PMID:20495215-1] 1.0 ^1.1 Tanaka, N et al. (2010) Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. J. Lipid Res. 51 2591-9 PubMed GONUTS page

[PMID:27477018-2] 2.0 ^2.1 Yeh, FL et al. (2016) TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron 91 328-40 PubMed GONUTS page

[PMID:11027668-3] Bocharov, AV et al. (2000) Heat shock protein 60 is a high-affinity high-density lipoprotein binding protein. Biochem. Biophys. Res. Commun. 277 228-35 PubMed GONUTS page

[PMID:23533145-4] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:22516433-5] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:19199708-6] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-7] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:10764676-8] 8.0 ^8.1 ^8.2 Pilon, A et al. (2000) Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake. Arterioscler. Thromb. Vasc. Biol. 20 1074-81 PubMed GONUTS page

[PMID:8106353-9] 9.0 ^9.1 ^9.2 Lagrost, L et al. (1994) Influence of apolipoprotein composition of high density lipoprotein particles on cholesteryl ester transfer protein activity. Particles containing various proportions of apolipoproteins AI and AII. J. Biol. Chem. 269 3189-97 PubMed GONUTS page

[PMID:14967812-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 Boucher, J et al. (2004) Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. J. Lipid Res. 45 849-58 PubMed GONUTS page

[PMID:8640403-11] Mowri, HO et al. (1996) Apolipoprotein A-II influences the substrate properties of human HDL2 and HDL3 for hepatic lipase. Arterioscler. Thromb. Vasc. Biol. 16 755-62 PubMed GONUTS page

[PMID:8245722-12] 12.0 ^12.1 ^12.2 ^12.3 Connelly, PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J. Lipid Res. 34 1717-27 PubMed GONUTS page

[PMID:17264082-13] 13.0 ^13.1 ^13.2 Silva, RA et al. (2007) The structure of apolipoprotein A-II in discoidal high density lipoproteins. J. Biol. Chem. 282 9713-21 PubMed GONUTS page

[PMID:218942-14] 14.0 ^14.1 ^14.2 Ritter, MC & Scanu, AM (1979) Apolipoprotein A-II and structure of human serum high density lipoproteins. An approach by reassembly techniques. J. Biol. Chem. 254 2517-25 PubMed GONUTS page

[PMID:16682745-15] Christoffersen, C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J. Lipid Res. 47 1833-43 PubMed GONUTS page

[PMID:210174-16] Weisgraber, KH & Mahley, RW (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J. Biol. Chem. 253 6281-8 PubMed GONUTS page

[PMID:3104518-17] Cheung, MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J. Lipid Res. 27 1135-44 PubMed GONUTS page

[PMID:11162594-18] 18.0 ^18.1 ^18.2 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page

[PMID:8636092-19] Marzal-Casacuberta, A et al. (1996) Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II. J. Biol. Chem. 271 6720-8 PubMed GONUTS page

[PMID:9651324-20] Wang, WQ et al. (1998) Enhanced cholesterol efflux by tyrosyl radical-oxidized high density lipoprotein is mediated by apolipoprotein AI-AII heterodimers. J. Biol. Chem. 273 17391-8 PubMed GONUTS page

[PMID:14988251-21] Sauvaget, D et al. (2004) In vitro transcriptional induction of the human apolipoprotein A-II gene by glucose. Diabetes 53 672-8 PubMed GONUTS page

[PMID:1606170-22] Bekaert, ED et al. (1992) Isolation and partial characterization of lipoprotein A-II (LP-A-II) particles of human plasma. Biochim. Biophys. Acta 1126 105-13 PubMed GONUTS page

[PMID:12458630-23] Furlaneto, CJ et al. (2002) Apolipoproteins A-I and A-II downregulate neutrophil functions. Lipids 37 925-8 PubMed GONUTS page

[PMID:7918467-24] Yang, CY et al. (1994) Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links. Biochemistry 33 12451-5 PubMed GONUTS page

[PMID:11591715-25] Klezovitch, O et al. (2001) Stimulation of interleukin-8 production in human THP-1 macrophages by apolipoprotein(a). Evidence for a critical involvement of elements in its C-terminal domain. J. Biol. Chem. 276 46864-9 PubMed GONUTS page

[PMID:12576517-26] 26.0 ^26.1 Pankhurst, G et al. (2003) Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein. J. Lipid Res. 44 349-55 PubMed GONUTS page

[PMID:14718574-27] Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

[PMID:21873635-28] 28.00 ^28.01 ^28.02 ^28.03 ^28.04 ^28.05 ^28.06 ^28.07 ^28.08 ^28.09 ^28.10 ^28.11 ^28.12 ^28.13 ^28.14 ^28.15 ^28.16 ^28.17 ^28.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11551871-29] van 't Hooft, FM et al. (2001) Human evidence that the apolipoprotein a-II gene is implicated in visceral fat accumulation and metabolism of triglyceride-rich lipoproteins. Circulation 104 1223-8 PubMed GONUTS page

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