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HUMAN:ANXA4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ANXA4 (synonyms: ANX4) | |
| Protein Name(s) | Annexin A4
35-beta calcimedin Annexin IV Annexin-4 Carbohydrate-binding protein p33/p41 Chromobindin-4 Endonexin I Lipocortin IV P32.5 PP4-X Placental anticoagulant protein II PAP-II Protein II | |
| External Links | ||
| UniProt | P09525 | |
| EMBL | M19383 M82809 D78152 AK293177 AC019206 AC092431 AC112787 BC000182 BC011659 | |
| PIR | A42077 | |
| RefSeq | NP_001144.1 | |
| UniGene | Hs.422986 | |
| PDB | 2ZOC | |
| PDBsum | 2ZOC | |
| ProteinModelPortal | P09525 | |
| SMR | P09525 | |
| BioGrid | 106804 | |
| IntAct | P09525 | |
| MINT | MINT-4528752 | |
| STRING | 9606.ENSP00000377833 | |
| PhosphoSite | P09525 | |
| DMDM | 1703319 | |
| DOSAC-COBS-2DPAGE | P09525 | |
| OGP | P09525 | |
| REPRODUCTION-2DPAGE | IPI00793199 P09525 | |
| SWISS-2DPAGE | P09525 | |
| MaxQB | P09525 | |
| PaxDb | P09525 | |
| PRIDE | P09525 | |
| DNASU | 307 | |
| Ensembl | ENST00000394295 ENST00000536030 | |
| GeneID | 307 | |
| KEGG | hsa:307 | |
| UCSC | uc010yqo.2 | |
| CTD | 307 | |
| GeneCards | GC02P069872 | |
| HGNC | HGNC:542 | |
| HPA | CAB005076 CAB017560 HPA007393 | |
| MIM | 106491 | |
| neXtProt | NX_P09525 | |
| PharmGKB | PA24832 | |
| eggNOG | NOG267770 | |
| HOVERGEN | HBG061815 | |
| InParanoid | P09525 | |
| KO | K17093 | |
| PhylomeDB | P09525 | |
| TreeFam | TF105452 | |
| ChiTaRS | ANXA4 | |
| EvolutionaryTrace | P09525 | |
| GeneWiki | ANXA4 | |
| GenomeRNAi | 307 | |
| NextBio | 1239 | |
| PRO | PR:P09525 | |
| Proteomes | UP000005640 UP000005640 | |
| Bgee | P09525 | |
| CleanEx | HS_ANXA4 | |
| ExpressionAtlas | P09525 | |
| Genevestigator | P09525 | |
| GO | GO:0009986 GO:0005737 GO:0070062 GO:0031965 GO:0005634 GO:0048471 GO:0005886 GO:0012506 GO:0005509 GO:0005544 GO:0048306 GO:0042802 GO:0051059 GO:0004859 GO:0030855 GO:0043066 GO:0043086 GO:2000483 GO:0032088 GO:0006357 GO:0007165 | |
| Gene3D | 1.10.220.10 | |
| InterPro | IPR001464 IPR018502 IPR018252 IPR002391 | |
| PANTHER | PTHR10502:SF28 | |
| Pfam | PF00191 | |
| PRINTS | PR00196 | |
| SMART | SM00335 | |
| PROSITE | PS00223 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0050673 |
epithelial cell proliferation |
PMID:P09525 |
ECO:0000317 |
P |
Fig 1 states overexpression of ANXA4 induces cell proliferation |
Missing: with/from | ||||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0003688) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001155) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000483 |
negative regulation of interleukin-8 secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051059 |
NF-kappaB binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:P19838:PRO_0000030311 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051059 |
NF-kappaB binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
part_of:(GO:0006357) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000639) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030855 |
epithelial cell differentiation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
results_in_acquisition_of_features_of:(CL:1000334) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
inhibited_by:(CHEBI:60888) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
occurs_in:(GO:0005886)|occurs_in:(GO:0031965) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0012506 |
vesicle membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005544 |
calcium-dependent phospholipid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005544 |
calcium-dependent phospholipid binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004859 |
phospholipase inhibitor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001314045 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001314045 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035374 |
chondroitin sulfate binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001314045 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030855 |
epithelial cell differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001314045 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008201 |
heparin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001314045 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007219 |
Notch signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88030 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97769 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002574842 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97769 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001314045 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001314045 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043086 |
negative regulation of catalytic activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004859 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007219 |
Notch signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97429 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001464 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005544 |
calcium-dependent phospholipid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001464 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005544 |
calcium-dependent phospholipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
- ↑ Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 4.0 4.1 Iwasa, T et al. (2012) Suppression of MIP-2 or IL-8 production by annexins A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils. Biochim. Biophys. Acta 1822 204-11 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Jeon, YJ et al. (2010) Annexin A4 interacts with the NF-kappaB p50 subunit and modulates NF-kappaB transcriptional activity in a Ca2+-dependent manner. Cell. Mol. Life Sci. 67 2271-81 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
- ↑ Buhrke, T et al. (2011) Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Dev. Growth Differ. 53 411-26 PubMed GONUTS page
- ↑ Ling, TY et al. (2004) Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. J. Biol. Chem. 279 38736-48 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 Piljic, A & Schultz, C (2006) Annexin A4 self-association modulates general membrane protein mobility in living cells. Mol. Biol. Cell 17 3318-28 PubMed GONUTS page
- ↑ Blackwood, RA & Ernst, JD (1990) Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Biochem. J. 266 195-200 PubMed GONUTS page
- ↑ 13.0 13.1 Grundmann, U et al. (1988) Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family. Behring Inst. Mitt. 59-67 PubMed GONUTS page
- ↑ 14.00 14.01 14.02 14.03 14.04 14.05 14.06 14.07 14.08 14.09 14.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page
c
- GO:0005544 ! calcium-dependent phospholipid binding
- GO:0048306 ! calcium-dependent protein binding
- GO:0005509 ! calcium ion binding
- Catarrhini
- GO:0009986 ! cell surface
- GO:0035374 ! chondroitin sulfate binding
- Chordata
- GO:0062023 ! collagen-containing extracellular matrix
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
e
n
- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:0043086 ! negative regulation of catalytic activity
- GO:0043066 ! negative regulation of apoptotic process
- GO:2000483 ! negative regulation of interleukin-8 secretion
- GO:0051059 ! NF-kappaB binding
- GO:0007219 ! Notch signaling pathway
- GO:0031965 ! nuclear membrane
- GO:0005634 ! nucleus
p
