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HUMAN:ANM1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PRMT1 (synonyms: HMT2, HRMT1L2, IR1B4)
Protein Name(s) Protein arginine N-methyltransferase 1

Histone-arginine N-methyltransferase PRMT1 Interferon receptor 1-bound protein 4

External Links
UniProt Q99873
EMBL Y10805
Y10806
Y10807
D66904
AF222689
AF222689
AF222689
AK304660
CR407608
AC011495
CH471177
BC019268
BC109282
BC109283
CCDS CCDS42592.1
RefSeq NP_001527.3
NP_938074.2
UniGene Hs.20521
ProteinModelPortal Q99873
SMR Q99873
BioGrid 109512
DIP DIP-30878N
IntAct Q99873
MINT MINT-4861475
BindingDB Q99873
ChEMBL CHEMBL5524
GuidetoPHARMACOLOGY 1252
PhosphoSite Q99873
DMDM 161789011
MaxQB Q99873
PaxDb Q99873
PRIDE Q99873
DNASU 3276
Ensembl ENST00000391851
GeneID 3276
KEGG hsa:3276
UCSC uc002ppe.3
uc021uxu.1
CTD 3276
GeneCards GC19P050181
HGNC HGNC:5187
HPA CAB022550
MIM 602950
neXtProt NX_Q99873
PharmGKB PA29461
eggNOG COG0500
GeneTree ENSGT00550000074406
HOVERGEN HBG001793
InParanoid Q99873
KO K11434
PhylomeDB Q99873
Reactome REACT_228108
SABIO-RK Q99873
SignaLink Q99873
ChiTaRS PRMT1
GeneWiki PRMT1
GenomeRNAi 3276
NextBio 13013
PRO PR:Q99873
Proteomes UP000005640
Bgee Q99873
CleanEx HS_PRMT1
ExpressionAtlas Q99873
Genevestigator Q99873
GO GO:0005737
GO:0005829
GO:0005654
GO:0005634
GO:0042054
GO:0044020
GO:0042802
GO:0008168
GO:0008170
GO:0044822
GO:0035242
GO:0007166
GO:0043985
GO:0016571
GO:0045653
GO:0031175
GO:0018216
GO:0019919
GO:0006479
GO:0006355
Gene3D 3.40.50.150
InterPro IPR025799
IPR025714
IPR029063
PANTHER PTHR11006
Pfam PF13847
SUPFAM SSF53335
PROSITE PS51678

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0035242

protein-arginine omega-N asymmetric methyltransferase activity

PMID:26575292[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0035241

protein-arginine omega-N monomethyltransferase activity

PMID:26575292[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0018216

peptidyl-arginine methylation

PMID:26575292[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045652

regulation of megakaryocyte differentiation

PMID:26575292[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:28040436[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006479

protein methylation

PMID:28040436[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008276

protein methyltransferase activity

PMID:28040436[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1900745

positive regulation of p38MAPK cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63009

P

Seeded From UniProt

complete

involved_in

GO:0046985

positive regulation of hemoglobin biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63009

P

Seeded From UniProt

complete

enables

GO:0044020

histone methyltransferase activity (H4-R3 specific)

PMID:25284789[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0034709

methylosome

PMID:25284789[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0035242

protein-arginine omega-N asymmetric methyltransferase activity

PMID:25284789[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008327

methyl-CpG binding

PMID:25284789[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045648

positive regulation of erythrocyte differentiation

PMID:23483889[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0048273

mitogen-activated protein kinase p38 binding

PMID:23483889[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q16539

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:19460357[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P23396

F

Seeded From UniProt

complete

involved_in

GO:0018216

peptidyl-arginine methylation

PMID:19460357[5]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P23396)

Seeded From UniProt

complete

enables

GO:0008276

protein methyltransferase activity

PMID:19460357[5]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(UniProtKB:P23396)

Seeded From UniProt

complete

involved_in

GO:0006479

protein methylation

PMID:26876602[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:26876602[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

PMID:26876602[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:1904047

S-adenosyl-L-methionine binding

PMID:26876602[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:26876602[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045653

negative regulation of megakaryocyte differentiation

PMID:20442406[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0044020

histone methyltransferase activity (H4-R3 specific)

PMID:11448779[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043985

histone H4-R3 methylation

PMID:11448779[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042054

histone methyltransferase activity

PMID:19405910[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0031175

neuron projection development

PMID:18773938[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018216

peptidyl-arginine methylation

PMID:18657504[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016571

histone methylation

PMID:19405910[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008170

N-methyltransferase activity

PMID:19124016[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008170

N-methyltransferase activity

PMID:18657504[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043985

histone H4-R3 methylation

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000109552
UniProtKB:Q99873

P

Seeded From UniProt

complete

enables

GO:0035242

protein-arginine omega-N asymmetric methyltransferase activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037770
FB:FBgn0037834
MGI:MGI:107846
MGI:MGI:1913208
PANTHER:PTN000109455
RGD:62020
RGD:620413
SGD:S000000238
TAIR:locus:2010607
TAIR:locus:2077567
TAIR:locus:2154339
UniProtKB:Q7Q2B7
UniProtKB:Q96LA8
UniProtKB:Q99873
UniProtKB:Q9NR22
WB:WBGene00013766

F

Seeded From UniProt

complete

involved_in

GO:0034969

histone arginine methylation

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913208
MGI:MGI:2384879
PANTHER:PTN000109455
UniProtKB:Q582G4

P

Seeded From UniProt

complete

involved_in

GO:0019919

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037770
FB:FBgn0037834
MGI:MGI:107846
PANTHER:PTN000109455
PomBase:SPAC890.07c
PomBase:SPBC8D2.10c
RGD:62020
RGD:620413
TAIR:locus:2010607
TAIR:locus:2077567
TAIR:locus:2154339
UniProtKB:Q7Q2B7
UniProtKB:Q96LA8
UniProtKB:Q9NR22
WB:WBGene00013766

P

Seeded From UniProt

complete

enables

GO:0008469

histone-arginine N-methyltransferase activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1316652
MGI:MGI:2139971
PANTHER:PTN000109455
RGD:62020
TAIR:locus:2010607
TAIR:locus:2077567
TAIR:locus:2154339
UniProtKB:C8V494
UniProtKB:C8VIM6
UniProtKB:Q86X55
UniProtKB:Q96LA8
UniProtKB:Q9NR22
UniProtKB:Q9NVM4
WB:WBGene00013766

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913208
PANTHER:PTN000109455
UniProtKB:Q7Q2B7

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913208
MGI:MGI:1919224
PANTHER:PTN000109455
RGD:62020
TAIR:locus:2010607
TAIR:locus:2051995
TAIR:locus:2082244
TAIR:locus:2134328
UniProtKB:P55345
UniProtKB:Q86X55
UniProtKB:Q9NVM4

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001663148
PomBase:SPAC890.07c
RGD:62020
SGD:S000000238
TAIR:locus:2134328
UniProtKB:Q8ILK1
UniProtKB:Q99873

C

Seeded From UniProt

complete

enables

GO:0016274

protein-arginine N-methyltransferase activity

PMID:18316480[15]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016274

protein-arginine N-methyltransferase activity

PMID:18495660[16]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10749851[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[18]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99873

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:23455924[19]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99873

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16169070[20]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99873

F

Seeded From UniProt

complete

enables

GO:0042054

histone methyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JIF0
ensembl:ENSMUSP00000103474

F

Seeded From UniProt

complete

enables

GO:0016274

protein-arginine N-methyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JIF0
ensembl:ENSMUSP00000103474

F

Seeded From UniProt

complete

enables

GO:0008276

protein methyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JIF0
ensembl:ENSMUSP00000103474

F

Seeded From UniProt

complete

involved_in

GO:0001701

in utero embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JIF0
ensembl:ENSMUSP00000103474

P

Seeded From UniProt

complete

involved_in

GO:0006479

protein methylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR025799

P

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR025799

F

Seeded From UniProt

complete

enables

GO:0008170

N-methyltransferase activity

PMID:9029147[21]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

PMID:9545638[22]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

PMID:9029147[21]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006479

protein methylation

PMID:9545638[22]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:9029147[21]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045652

regulation of megakaryocyte differentiation

Reactome:R-HSA-8936459

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016274

protein-arginine N-methyltransferase activity

Reactome:R-HSA-5205867

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Reactome:R-HSA-6791312

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-9023861
Reactome:R-HSA-9023860
Reactome:R-HSA-8937050
Reactome:R-HSA-8937037
Reactome:R-HSA-8937016
Reactome:R-HSA-8936979
Reactome:R-HSA-8936621
Reactome:R-HSA-8936616
Reactome:R-HSA-8936481
Reactome:R-HSA-8935740
Reactome:R-HSA-8934742
Reactome:R-HSA-8934735
Reactome:R-HSA-5661126
Reactome:R-HSA-5205867
Reactome:R-HSA-5205798
Reactome:R-HSA-3215152

ECO:0000304

author statement supported by traceable reference used in manual assertion
















C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Zhang, L et al. (2015) Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. Elife 4 PubMed GONUTS page
  2. 2.0 2.1 2.2 Akter, KA et al. (2017) FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression. Int. J. Biochem. Cell Biol. 84 1-13 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Takai, H et al. (2014) 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. Cell Rep 9 48-60 PubMed GONUTS page
  4. 4.0 4.1 Hua, WK et al. (2013) Protein arginine methyltransferase 1 interacts with and activates p38α to facilitate erythroid differentiation. PLoS ONE 8 e56715 PubMed GONUTS page
  5. 5.0 5.1 5.2 Shin, HS et al. (2009) Arginine methylation of ribosomal protein S3 affects ribosome assembly. Biochem. Biophys. Res. Commun. 385 273-8 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Toma-Fukai, S et al. (2016) Novel helical assembly in arginine methyltransferase 8. J. Mol. Biol. 428 1197-1208 PubMed GONUTS page
  7. Chang, YI et al. (2010) Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells. J. Biol. Chem. 285 20595-606 PubMed GONUTS page
  8. Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  9. 9.0 9.1 Strahl, BD et al. (2001) Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr. Biol. 11 996-1000 PubMed GONUTS page
  10. 10.0 10.1 Lakowski, TM & Frankel, A (2009) Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. Biochem. J. 421 253-61 PubMed GONUTS page
  11. Miyata, S et al. (2008) PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells. Neurosci. Lett. 445 162-5 PubMed GONUTS page
  12. 12.0 12.1 Le Romancer, M et al. (2008) Regulation of estrogen rapid signaling through arginine methylation by PRMT1. Mol. Cell 31 212-21 PubMed GONUTS page
  13. Jobert, L et al. (2009) PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function. Exp. Cell Res. 315 1273-86 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 14.5 14.6 14.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  15. Zhao, X et al. (2008) Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes Dev. 22 640-53 PubMed GONUTS page
  16. Fronz, K et al. (2008) Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. J. Biol. Chem. 283 20408-20 PubMed GONUTS page
  17. Tang, J et al. (2000) Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. J. Biol. Chem. 275 19866-76 PubMed GONUTS page
  18. Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  19. Weimann, M et al. (2013) A Y2H-seq approach defines the human protein methyltransferase interactome. Nat. Methods 10 339-42 PubMed GONUTS page
  20. Stelzl, U et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122 957-68 PubMed GONUTS page
  21. 21.0 21.1 21.2 Abramovich, C et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16 260-6 PubMed GONUTS page
  22. 22.0 22.1 Scott, HS et al. (1998) Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). Genomics 48 330-40 PubMed GONUTS page