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HUMAN:ANM1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | PRMT1 (synonyms: HMT2, HRMT1L2, IR1B4) | |
Protein Name(s) | Protein arginine N-methyltransferase 1
Histone-arginine N-methyltransferase PRMT1 Interferon receptor 1-bound protein 4 | |
External Links | ||
UniProt | Q99873 | |
EMBL | Y10805 Y10806 Y10807 D66904 AF222689 AF222689 AF222689 AK304660 CR407608 AC011495 CH471177 BC019268 BC109282 BC109283 | |
CCDS | CCDS42592.1 | |
RefSeq | NP_001527.3 NP_938074.2 | |
UniGene | Hs.20521 | |
ProteinModelPortal | Q99873 | |
SMR | Q99873 | |
BioGrid | 109512 | |
DIP | DIP-30878N | |
IntAct | Q99873 | |
MINT | MINT-4861475 | |
BindingDB | Q99873 | |
ChEMBL | CHEMBL5524 | |
GuidetoPHARMACOLOGY | 1252 | |
PhosphoSite | Q99873 | |
DMDM | 161789011 | |
MaxQB | Q99873 | |
PaxDb | Q99873 | |
PRIDE | Q99873 | |
DNASU | 3276 | |
Ensembl | ENST00000391851 | |
GeneID | 3276 | |
KEGG | hsa:3276 | |
UCSC | uc002ppe.3 uc021uxu.1 | |
CTD | 3276 | |
GeneCards | GC19P050181 | |
HGNC | HGNC:5187 | |
HPA | CAB022550 | |
MIM | 602950 | |
neXtProt | NX_Q99873 | |
PharmGKB | PA29461 | |
eggNOG | COG0500 | |
GeneTree | ENSGT00550000074406 | |
HOVERGEN | HBG001793 | |
InParanoid | Q99873 | |
KO | K11434 | |
PhylomeDB | Q99873 | |
Reactome | REACT_228108 | |
SABIO-RK | Q99873 | |
SignaLink | Q99873 | |
ChiTaRS | PRMT1 | |
GeneWiki | PRMT1 | |
GenomeRNAi | 3276 | |
NextBio | 13013 | |
PRO | PR:Q99873 | |
Proteomes | UP000005640 | |
Bgee | Q99873 | |
CleanEx | HS_PRMT1 | |
ExpressionAtlas | Q99873 | |
Genevestigator | Q99873 | |
GO | GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0042054 GO:0044020 GO:0042802 GO:0008168 GO:0008170 GO:0044822 GO:0035242 GO:0007166 GO:0043985 GO:0016571 GO:0045653 GO:0031175 GO:0018216 GO:0019919 GO:0006479 GO:0006355 | |
Gene3D | 3.40.50.150 | |
InterPro | IPR025799 IPR025714 IPR029063 | |
PANTHER | PTHR11006 | |
Pfam | PF13847 | |
SUPFAM | SSF53335 | |
PROSITE | PS51678 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0035242 |
protein-arginine omega-N asymmetric methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0035241 |
protein-arginine omega-N monomethyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0018216 |
peptidyl-arginine methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045652 |
regulation of megakaryocyte differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006479 |
protein methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008276 |
protein methyltransferase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1900745 |
positive regulation of p38MAPK cascade |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046985 |
positive regulation of hemoglobin biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044020 |
histone methyltransferase activity (H4-R3 specific) |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0034709 |
methylosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0035242 |
protein-arginine omega-N asymmetric methyltransferase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008327 |
methyl-CpG binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045648 |
positive regulation of erythrocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0048273 |
mitogen-activated protein kinase p38 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0018216 |
peptidyl-arginine methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P23396) |
Seeded From UniProt |
complete | ||
enables |
GO:0008276 |
protein methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_regulation_target:(UniProtKB:P23396) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006479 |
protein methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051260 |
protein homooligomerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:1904047 |
S-adenosyl-L-methionine binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045653 |
negative regulation of megakaryocyte differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0044020 |
histone methyltransferase activity (H4-R3 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043985 |
histone H4-R3 methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042054 |
histone methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031175 |
neuron projection development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0018216 |
peptidyl-arginine methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016571 |
histone methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008170 |
N-methyltransferase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008170 |
N-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043985 |
histone H4-R3 methylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000109552 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0035242 |
protein-arginine omega-N asymmetric methyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0037770 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034969 |
histone arginine methylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913208 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019919 |
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0037770 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008469 |
histone-arginine N-methyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1316652 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913208 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913208 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001663148 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0016274 |
protein-arginine N-methyltransferase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016274 |
protein-arginine N-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042054 |
histone methyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JIF0 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0016274 |
protein-arginine N-methyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JIF0 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008276 |
protein methyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JIF0 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001701 |
in utero embryonic development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JIF0 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006479 |
protein methylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008170 |
N-methyltransferase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006479 |
protein methylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045652 |
regulation of megakaryocyte differentiation |
Reactome:R-HSA-8936459 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0016274 |
protein-arginine N-methyltransferase activity |
Reactome:R-HSA-5205867 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006977 |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
Reactome:R-HSA-6791312 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-9023861 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Zhang, L et al. (2015) Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. Elife 4 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Akter, KA et al. (2017) FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression. Int. J. Biochem. Cell Biol. 84 1-13 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Takai, H et al. (2014) 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. Cell Rep 9 48-60 PubMed GONUTS page
- ↑ 4.0 4.1 Hua, WK et al. (2013) Protein arginine methyltransferase 1 interacts with and activates p38α to facilitate erythroid differentiation. PLoS ONE 8 e56715 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Shin, HS et al. (2009) Arginine methylation of ribosomal protein S3 affects ribosome assembly. Biochem. Biophys. Res. Commun. 385 273-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Toma-Fukai, S et al. (2016) Novel helical assembly in arginine methyltransferase 8. J. Mol. Biol. 428 1197-1208 PubMed GONUTS page
- ↑ Chang, YI et al. (2010) Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells. J. Biol. Chem. 285 20595-606 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ 9.0 9.1 Strahl, BD et al. (2001) Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr. Biol. 11 996-1000 PubMed GONUTS page
- ↑ 10.0 10.1 Lakowski, TM & Frankel, A (2009) Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. Biochem. J. 421 253-61 PubMed GONUTS page
- ↑ Miyata, S et al. (2008) PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells. Neurosci. Lett. 445 162-5 PubMed GONUTS page
- ↑ 12.0 12.1 Le Romancer, M et al. (2008) Regulation of estrogen rapid signaling through arginine methylation by PRMT1. Mol. Cell 31 212-21 PubMed GONUTS page
- ↑ Jobert, L et al. (2009) PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function. Exp. Cell Res. 315 1273-86 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 14.5 14.6 14.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Zhao, X et al. (2008) Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes Dev. 22 640-53 PubMed GONUTS page
- ↑ Fronz, K et al. (2008) Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. J. Biol. Chem. 283 20408-20 PubMed GONUTS page
- ↑ Tang, J et al. (2000) Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. J. Biol. Chem. 275 19866-76 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
- ↑ Weimann, M et al. (2013) A Y2H-seq approach defines the human protein methyltransferase interactome. Nat. Methods 10 339-42 PubMed GONUTS page
- ↑ Stelzl, U et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122 957-68 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 Abramovich, C et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16 260-6 PubMed GONUTS page
- ↑ 22.0 22.1 Scott, HS et al. (1998) Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). Genomics 48 330-40 PubMed GONUTS page
c
h
m
n
o
p
- GO:0019919 ! peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
- GO:0018216 ! peptidyl-arginine methylation
- GO:0046985 ! positive regulation of hemoglobin biosynthetic process
- GO:0045648 ! positive regulation of erythrocyte differentiation
- GO:0008284 ! positive regulation of cell population proliferation
- GO:1900745 ! positive regulation of p38MAPK cascade
- Primates
- GO:0016274 ! protein-arginine N-methyltransferase activity
- GO:0035242 ! protein-arginine omega-N asymmetric methyltransferase activity
- GO:0035241 ! protein-arginine omega-N monomethyltransferase activity
- GO:0051260 ! protein homooligomerization
- GO:0008276 ! protein methyltransferase activity
- GO:0006479 ! protein methylation
r