GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:AL4A1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ALDH4A1 (synonyms: ALDH4, P5CDH)
Protein Name(s) Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

P5C dehydrogenase Aldehyde dehydrogenase family 4 member A1 L-glutamate gamma-semialdehyde dehydrogenase

External Links
UniProt P30038
EMBL U24267
U24266
FJ462711
AK289972
AK294552
AK222486
AL080251
AL954340
AL954340
AL080251
BX537160
CH471134
BC007581
BC023600
CCDS CCDS188.1
CCDS53272.1
RefSeq NP_001154976.1
NP_003739.2
NP_733844.1
UniGene Hs.77448
PDB 3V9G
3V9H
3V9I
4OE5
PDBsum 3V9G
3V9H
3V9I
4OE5
ProteinModelPortal P30038
SMR P30038
BioGrid 114208
IntAct P30038
STRING 9606.ENSP00000290597
PhosphoSite P30038
DMDM 62511241
OGP P30038
SWISS-2DPAGE P30038
MaxQB P30038
PaxDb P30038
PRIDE P30038
DNASU 8659
Ensembl ENST00000290597
ENST00000375341
ENST00000538309
ENST00000538839
GeneID 8659
KEGG hsa:8659
UCSC uc001bbb.3
uc021ohl.1
CTD 8659
GeneCards GC01M019197
HGNC HGNC:406
HPA CAB004645
HPA006401
MIM 239510
606811
neXtProt NX_P30038
Orphanet 79101
PharmGKB PA24701
eggNOG COG1012
GeneTree ENSGT00560000077335
HOVERGEN HBG050484
InParanoid P30038
KO K00294
OMA LTDWKYP
OrthoDB EOG7T1R9D
PhylomeDB P30038
TreeFam TF300481
BioCyc MetaCyc:HS14757-MONOMER
Reactome REACT_1002
SABIO-RK P30038
UniPathway UPA00261
ChiTaRS ALDH4A1
GeneWiki Aldehyde_dehydrogenase_4_family,_member_A1
GenomeRNAi 8659
NextBio 32473
PRO PR:P30038
Proteomes UP000005640
Bgee P30038
CleanEx HS_ALDH4A1
ExpressionAtlas P30038
Genevestigator P30038
GO GO:0005759
GO:0003842
GO:0004029
GO:0009055
GO:0042802
GO:0019470
GO:0034641
GO:0006537
GO:0006561
GO:0006562
GO:0010133
GO:0006560
GO:0044281
Gene3D 3.40.309.10
3.40.605.10
InterPro IPR016161
IPR016163
IPR016160
IPR029510
IPR016162
IPR015590
IPR005931
Pfam PF00171
SUPFAM SSF53720
TIGRFAMs TIGR01236
PROSITE PS00070
PS00687

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004029

aldehyde dehydrogenase (NAD) activity

PMID:4015840[1]

ECO:0000314

F

Table 1, The gels were stained for ALDH activity with an agar overlay containing propionaldehyde or benzaldehyde

complete
CACAO 8806

enables

GO:0004029

aldehyde dehydrogenase (NAD) activity

PMID:4015840[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003842

1-pyrroline-5-carboxylate dehydrogenase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2443883
PANTHER:PTN002684348
UniProtKB:P30038

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22516612[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P30038

F

Seeded From UniProt

complete

involved_in

GO:0022900

electron transport chain

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0009055

P

Seeded From UniProt

complete

enables

GO:0003842

1-pyrroline-5-carboxylate dehydrogenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CHT0
ensembl:ENSMUSP00000043821

F

Seeded From UniProt

complete

enables

GO:0003842

1-pyrroline-5-carboxylate dehydrogenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005931

F

Seeded From UniProt

complete

involved_in

GO:0010133

proline catabolic process to glutamate

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005931

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015590
InterPro:IPR016160
InterPro:IPR016161
InterPro:IPR016162
InterPro:IPR016163
InterPro:IPR029510

F

Seeded From UniProt

complete

enables

GO:0016620

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016163

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015590
InterPro:IPR016160
InterPro:IPR016161
InterPro:IPR016162
InterPro:IPR016163
InterPro:IPR029510

P

Seeded From UniProt

complete

involved_in

GO:0006562

proline catabolic process

PMID:8621661[4]
Reactome:R-HSA-70688

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006560

proline metabolic process

PMID:8621661[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:8621661[4]
Reactome:R-HSA-70679
Reactome:R-HSA-6784399

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0004029

aldehyde dehydrogenase (NAD) activity

PMID:8621661[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003842

1-pyrroline-5-carboxylate dehydrogenase activity

PMID:8621661[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019470

4-hydroxyproline catabolic process

PMID:21998747[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0009055

electron transfer activity

PMID:8621661[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046487

glyoxylate metabolic process

Reactome:R-HSA-6784399

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0006560

proline metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0642

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

involved_in

GO:0010133

proline catabolic process to glutamate

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00261

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Hopkinson, DA et al. () Biochemical genetic analysis of human and rodent aldehyde dehydrogenase (ALDH). Alcohol 2 73-8 PubMed GONUTS page
  2. ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Srivastava, D et al. (2012) The three-dimensional structural basis of type II hyperprolinemia. J. Mol. Biol. 420 176-89 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Hu, CA et al. (1996) Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase. J. Biol. Chem. 271 9795-800 PubMed GONUTS page
  5. ↑ Riedel, TJ et al. (2011) Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. PLoS ONE 6 e26021 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:AL4A1&oldid=5954152"