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Category:GO:0003842 ! L-glutamate gamma-semialdehyde dehydrogenase activity
name: L-glutamate gamma-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + 2 H+." [RHEA:30235]
comment: (S)-1-pyrroline-5-carboxylate is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde. The activity can also oxidize other 1-pyrrolines, e.g. oxidation of 3-hydroxy-1-pyrroline-5-carboxylate to 4-hydroxyglutamate, and oxidation of (R)-1-pyrroline-5-carboxylate to D-glutamate.
synonym: "1-pyrroline dehydrogenase" BROAD []
synonym: "1-pyrroline-5-carboxylate dehydrogenase activity" RELATED []
synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" RELATED []
synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" RELATED [EC:1.2.1.88]
synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" RELATED []
synonym: "pyrroline-5-carboxylate dehydrogenase activity" RELATED [EC:1.2.1.88]
synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" RELATED [EC:1.2.1.88]
xref: EC:1.2.1.88
xref: MetaCyc:RXN-14116
xref: RHEA:30235
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
AmiGO
<GOterm>GO:0003842</GOterm>
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