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HUMAN:AL3A1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ALDH3A1 (synonyms: ALDH3)
Protein Name(s) Aldehyde dehydrogenase, dimeric NADP-preferring

ALDHIII Aldehyde dehydrogenase 3 Aldehyde dehydrogenase family 3 member A1

External Links
UniProt P30838
EMBL M74542
M77477
S61044
BT007102
AK292193
AK314584
AC005722
CH471212
BC004370
BC008892
BC021194
CCDS CCDS11212.1
PIR A42584
RefSeq NP_000682.3
NP_001128639.1
NP_001128640.1
UniGene Hs.531682
PDB 3SZA
3SZB
4H80
4L1O
4L2O
PDBsum 3SZA
3SZB
4H80
4L1O
4L2O
ProteinModelPortal P30838
SMR P30838
BioGrid 106720
IntAct P30838
STRING 9606.ENSP00000225740
BindingDB P30838
ChEMBL CHEMBL3578
PhosphoSite P30838
DMDM 311033473
MaxQB P30838
PaxDb P30838
PRIDE P30838
DNASU 218
Ensembl ENST00000225740
ENST00000444455
ENST00000457500
GeneID 218
KEGG hsa:218
UCSC uc002gwj.3
CTD 218
GeneCards GC17M019641
H-InvDB HIX0013622
HGNC HGNC:405
HPA CAB045957
HPA051150
MIM 100660
neXtProt NX_P30838
PharmGKB PA24697
eggNOG COG1012
GeneTree ENSGT00390000002825
HOGENOM HOG000271515
HOVERGEN HBG050483
InParanoid P30838
KO K00129
OMA QKLPEWA
PhylomeDB P30838
TreeFam TF314264
SABIO-RK P30838
ChiTaRS ALDH3A1
EvolutionaryTrace P30838
GeneWiki Aldehyde_dehydrogenase_3_family,_member_A1
GenomeRNAi 218
NextBio 882
PRO PR:P30838
Proteomes UP000005640
Bgee P30838
CleanEx HS_ALDH3A1
ExpressionAtlas P30838
Genevestigator P30838
GO GO:0005737
GO:0005829
GO:0005783
GO:0005615
GO:0005886
GO:0004028
GO:0008106
GO:0004029
GO:0004030
GO:0007568
GO:0006081
GO:0055114
GO:0008284
GO:0051591
GO:0042493
GO:0051384
GO:0001666
GO:0007584
Gene3D 3.40.309.10
3.40.605.10
InterPro IPR016161
IPR016163
IPR016160
IPR029510
IPR016162
IPR015590
IPR012394
Pfam PF00171
PIRSF PIRSF036492
SUPFAM SSF53720
PROSITE PS00070
PS00687

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0018479

benzaldehyde dehydrogenase (NAD+) activity

PMID:4015840[1]

ECO:0000314

F

Table 1. The gels were stained for ALDH activity with an agar overlay containing propionaldehyde or benzaldehyde.

complete
CACAO 8521

enables

GO:0018479

benzaldehyde dehydrogenase (NAD+) activity

PMID:4015840[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:22664934[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:1737758[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008106

alcohol dehydrogenase (NADP+) activity

PMID:1737758[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006081

cellular aldehyde metabolic process

PMID:1737758[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11883

C

Seeded From UniProt

complete

enables

GO:0004029

aldehyde dehydrogenase (NAD) activity

PMID:1737758[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004028

3-chloroallyl aldehyde dehydrogenase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1353451
PANTHER:PTN000193230
RGD:2088
RGD:61866

F

Seeded From UniProt

complete

enables

GO:0004028

3-chloroallyl aldehyde dehydrogenase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1353451
PANTHER:PTN000193081
RGD:2088
RGD:61866

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051591

response to cAMP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

P

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

P

Seeded From UniProt

complete

involved_in

GO:0007584

response to nutrient

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

C

Seeded From UniProt

complete

enables

GO:0004028

3-chloroallyl aldehyde dehydrogenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

F

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11883
ensembl:ENSRNOP00000003182

P

Seeded From UniProt

complete

enables

GO:0016620

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47739
ensembl:ENSMUSP00000019246

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47739
ensembl:ENSMUSP00000019246

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47739
ensembl:ENSMUSP00000019246

C

Seeded From UniProt

complete

enables

GO:0004029

aldehyde dehydrogenase (NAD) activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47739
ensembl:ENSMUSP00000019246

F

Seeded From UniProt

complete

enables

GO:0004028

3-chloroallyl aldehyde dehydrogenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47739
ensembl:ENSMUSP00000019246

F

Seeded From UniProt

complete

involved_in

GO:0006081

cellular aldehyde metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012394

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015590
InterPro:IPR016160
InterPro:IPR016161
InterPro:IPR016162
InterPro:IPR016163
InterPro:IPR029510

F

Seeded From UniProt

complete

enables

GO:0016620

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016163

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012394
InterPro:IPR015590
InterPro:IPR016160
InterPro:IPR016161
InterPro:IPR016162
InterPro:IPR016163
InterPro:IPR029510

P

Seeded From UniProt

complete

enables

GO:0004030

aldehyde dehydrogenase [NAD(P)+] activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.2.1.5

F

Seeded From UniProt

complete

involved_in

GO:0006805

xenobiotic metabolic process

Reactome:R-HSA-211945

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5692283

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004030

aldehyde dehydrogenase [NAD(P)+] activity

Reactome:R-HSA-5692283

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Hopkinson, DA et al. () Biochemical genetic analysis of human and rodent aldehyde dehydrogenase (ALDH). Alcohol 2 73-8 PubMed GONUTS page
  2. ↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Hsu, LC et al. (1992) Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli. J. Biol. Chem. 267 3030-7 PubMed GONUTS page
  4. ↑ 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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