HUMAN:AKT3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AKT3 (synonyms: PKBG)
Protein Name(s)	RAC-gamma serine/threonine-protein kinase Protein kinase Akt-3 Protein kinase B gamma PKB gamma RAC-PK-gamma STK-2
External Links
UniProt	Q9Y243
EMBL	AF124141 AF135794 AF085234 AJ245709 AL117525 AY005799 AL591721 AC096539 AL592151 AL662889 AL591721 AC096539 AL592151 AL662889 AL592151 AC096539 AL591721 AL662889 AL592151 AC096539 AL591721 AL662889 AL662889 AC096539 AL591721 AL592151 AL662889 AC096539 AL591721 AL592151 CH471148 CH471148 BC121154
CCDS	CCDS31076.1 CCDS31077.1
PIR	A59380 T17287
RefSeq	NP_001193658.1 NP_005456.1 NP_859029.1 XP_005273051.1 XP_005273052.1 XP_006711788.1 XP_006725022.1 XP_006725023.1 XP_006725024.1
UniGene	Hs.498292
PDB	2X18
PDBsum	2X18
ProteinModelPortal	Q9Y243
SMR	Q9Y243
BioGrid	115318
DIP	DIP-32584N
IntAct	Q9Y243
MINT	MINT-222821
STRING	9606.ENSP00000263826
BindingDB	Q9Y243
ChEMBL	CHEMBL2111353
GuidetoPHARMACOLOGY	2286
PhosphoSite	Q9Y243
DMDM	12643943
MaxQB	Q9Y243
PaxDb	Q9Y243
PRIDE	Q9Y243
DNASU	10000
Ensembl	ENST00000263826 ENST00000336199 ENST00000366539 ENST00000366540 ENST00000613395 ENST00000619536 ENST00000621586
GeneID	10000
KEGG	hsa:10000
UCSC	uc001hzz.1 uc001iab.2
CTD	10000
GeneCards	GC01M243653
HGNC	HGNC:393
HPA	CAB013090 HPA026441
MIM	611223 615937
neXtProt	NX_Q9Y243
Orphanet	99802 83473
PharmGKB	PA24686
eggNOG	COG0515
GeneTree	ENSGT00770000120449
HOGENOM	HOG000233033
HOVERGEN	HBG108317
InParanoid	Q9Y243
KO	K04456
OMA	RGCQIMA
OrthoDB	EOG7Q5HCW
PhylomeDB	Q9Y243
TreeFam	TF102004
BRENDA	2.7.11.1
Reactome	REACT_115662 REACT_12442 REACT_12447 REACT_12564 REACT_13655 REACT_147727 REACT_1695 REACT_19290 REACT_19358 REACT_19405 REACT_228016 REACT_75829
SignaLink	Q9Y243
ChiTaRS	AKT3
GeneWiki	AKT3
GenomeRNAi	10000
NextBio	37765
PRO	PR:Q9Y243
Proteomes	UP000005640 UP000005640
Bgee	Q9Y243
CleanEx	HS_AKT3
ExpressionAtlas	Q9Y243
Genevestigator	Q9Y243
GO	GO:0005737 GO:0005794 GO:0005634 GO:0005886 GO:0005524 GO:0004672 GO:0004674 GO:0000002 GO:0006468 GO:0007165
Gene3D	2.30.29.30
InterPro	IPR000961 IPR011009 IPR001849 IPR011993 IPR017892 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00169 PF00069 PF00433
SMART	SM00233 SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS50003 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:28254819^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_movement_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1905564	positive regulation of vascular endothelial cell proliferation	PMID:28254819^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_division_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	PMID:25323119^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002619)	Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:25323119^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_movement_of:(CL:0002619)	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:25323119^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_division_of:(CL:0002619)	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:18524868^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:16540465^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16540465^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000002	mitochondrial genome maintenance	PMID:18524868^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003744 FB:FBgn0010379 MGI:MGI:97601 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAPB18E9.02c RGD:3395 RGD:3399 RGD:61925 RGD:620968 RGD:67383 SGD:S000000201 UniProtKB:O15530 UniProtKB:P31749 UniProtKB:Q15208 UniProtKB:Q9NRM7 UniProtKB:Q9Y2H1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87986 PANTHER:PTN000683254 RGD:2081 RGD:3395 RGD:3399 RGD:3668 RGD:61925 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000005460 UniProtKB:A0A1D5PUY5 UniProtKB:P31749 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q05513 UniProtKB:Q05655 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004033 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003091 FB:FBgn0003744 FB:FBgn0010379 FB:FBgn0260399 FB:FBgn0261854 MGI:MGI:104874 MGI:MGI:2182368 MGI:MGI:87986 MGI:MGI:894676 MGI:MGI:97595 MGI:MGI:97596 MGI:MGI:97599 MGI:MGI:97602 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAC24B11.11c PomBase:SPAC821.12 PomBase:SPAPB18E9.02c PomBase:SPCC576.15c RGD:2081 RGD:2082 RGD:3399 RGD:3668 RGD:620146 RGD:620968 RGD:62390 SGD:S000001248 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000003324 SGD:S000005105 SGD:S000005460 SGD:S000006315 TAIR:locus:2088515 UniProtKB:O15530 UniProtKB:O95835 UniProtKB:P05771 UniProtKB:P17252 UniProtKB:P31749 UniProtKB:P31751 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q04759 UniProtKB:Q05513 UniProtKB:Q05655 UniProtKB:Q09013 UniProtKB:Q15208 UniProtKB:Q16512 UniProtKB:Q16513 UniProtKB:Q96GX5 UniProtKB:Q9NRM7 UniProtKB:Q9XF67 UniProtKB:Q9Y243 UniProtKB:Q9Y2H1 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599 dictyBase:DDB_G0268620	F		Seeded From UniProt	complete
involved_in	GO:1905653	positive regulation of artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUA6 ensembl:ENSMUSP00000106789	P		Seeded From UniProt	complete
involved_in	GO:0048873	homeostasis of number of cells within a tissue	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUA6 ensembl:ENSMUSP00000106789	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUA6 ensembl:ENSMUSP00000106789	P		Seeded From UniProt	complete
involved_in	GO:0045793	positive regulation of cell size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUA6 ensembl:ENSMUSP00000106789	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUA6 ensembl:ENSMUSP00000106789	P		Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUA6 ensembl:ENSMUSP00000106789	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR017892 InterPro:IPR034675 InterPro:IPR039029	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441 InterPro:IPR017892	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR017892 InterPro:IPR034675	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039029	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10092583^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10092583^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10092583^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhu, LP et al. (2017) MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3). Arterioscler. Thromb. Vasc. Biol. 37 957-968 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Zheng, Y & Xu, Z (2014) MicroRNA-22 induces endothelial progenitor cell senescence by targeting AKT3. Cell. Physiol. Biochem. 34 1547-55 PubMed GONUTS page
↑ ^3.0 ^3.1 Wright, GL et al. (2008) VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. FASEB J. 22 3264-75 PubMed GONUTS page
↑ ^4.0 ^4.1 Zhang, X et al. (2006) Kinetic mechanism of AKT/PKB enzyme family. J. Biol. Chem. 281 13949-56 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Brodbeck, D et al. (1999) A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J. Biol. Chem. 274 9133-6 PubMed GONUTS page

[PMID:28254819-1] 1.0 ^1.1 Zhu, LP et al. (2017) MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3). Arterioscler. Thromb. Vasc. Biol. 37 957-968 PubMed GONUTS page

[PMID:25323119-2] 2.0 ^2.1 ^2.2 Zheng, Y & Xu, Z (2014) MicroRNA-22 induces endothelial progenitor cell senescence by targeting AKT3. Cell. Physiol. Biochem. 34 1547-55 PubMed GONUTS page

[PMID:18524868-3] 3.0 ^3.1 Wright, GL et al. (2008) VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. FASEB J. 22 3264-75 PubMed GONUTS page

[PMID:16540465-4] 4.0 ^4.1 Zhang, X et al. (2006) Kinetic mechanism of AKT/PKB enzyme family. J. Biol. Chem. 281 13949-56 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10092583-6] 6.0 ^6.1 ^6.2 Brodbeck, D et al. (1999) A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J. Biol. Chem. 274 9133-6 PubMed GONUTS page

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HUMAN:AKT3

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References

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