HUMAN:AKD1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AKD1 (synonyms: AKD2, C6orf199, C6orf224)
Protein Name(s)	Adenylate kinase domain-containing protein 1 Adenylate kinase domain-containing protein 2
External Links
UniProt	Q5TCS8
EMBL	AK055538 AK098657 AK124171 AK131244 AK315561 AL133472 AL121788 AL133472 AL121788 AL121788 AL133472 AL121788 AL133472 AL109947 AL139391 CH471051 BC022031 BC087860 BC101714 BC111948
IPI	IPI00418605 IPI00552962 IPI00556253 IPI00641136 IPI00856053 IPI00930224
RefSeq	NP_001138600.2 NP_659462.1
UniGene	Hs.205144
ProteinModelPortal	Q5TCS8
IntAct	Q5TCS8
MINT	MINT-1369939
PhosphoSite	Q5TCS8
DMDM	302393675
PaxDb	Q5TCS8
PRIDE	Q5TCS8
DNASU	221264
Ensembl	ENST00000285397 ENST00000355283 ENST00000424296
GeneID	221264
KEGG	hsa:221264
UCSC	uc003ptn.2
CTD	221264
GeneCards	GC06M109814
H-InvDB	HIX0025110 HIX0207381
HGNC	HGNC:33814
HPA	HPA031779
neXtProt	NX_Q5TCS8
PharmGKB	PA162380441 PA164715271
eggNOG	COG0563
HOVERGEN	HBG107661
InParanoid	Q6ZNF1
OMA	AQFLGEH
GenomeRNAi	221264
NextBio	91262
ArrayExpress	Q5TCS8
Bgee	Q5TCS8
CleanEx	HS_C6orf199
Genevestigator	Q5TCS8
GO	GO:0005524 GO:0019205 GO:0017111 GO:0006139
InterPro	IPR003593 IPR000850 IPR027417 IPR007029
PANTHER	PTHR23359
Pfam	PF00406 PF04945
SMART	SM00382
SUPFAM	SSF52540

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0055114	oxidation-reduction process	PMID:7508385^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008209	androgen metabolic process	PMID:7508385^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008207	C21-steroid hormone metabolic process	PMID:7508385^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007586	digestion	PMID:7508385^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006707	cholesterol catabolic process	PMID:7508385^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006699	bile acid biosynthetic process	PMID:7508385^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:7508385^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0047086	ketosteroid monooxygenase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000199026 UniProtKB:P42330 UniProtKB:P52895 UniProtKB:Q04828	F	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000198921 SGD:S000005646 UniProtKB:Q96JD6	F	Seeded From UniProt	complete
enables	GO:0016229	steroid dehydrogenase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000199026 RGD:708361	F	Seeded From UniProt	complete
involved_in	GO:0008209	androgen metabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000199133 UniProtKB:P51857	P	Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1933427 PANTHER:PTN000199026 UniProtKB:P42330 UniProtKB:P52895	P	Seeded From UniProt	complete
enables	GO:0008106	alcohol dehydrogenase (NADP+) activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13015 PANTHER:PTN000198921 TAIR:locus:2040646 UniProtKB:Q90W83	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13015 MGI:MGI:1929955 PANTHER:PTN000198921 RGD:2092 RGD:708428 RGD:708475 SGD:S000000353 TAIR:locus:2025936 TAIR:locus:2040751 TAIR:locus:2065639 TAIR:locus:2084505 UniProtKB:C9JRZ8 UniProtKB:P15121 UniProtKB:P51857 UniProtKB:Q04828 UniProtKB:Q96JD6 UniProtKB:Q9SJV2 dictyBase:DDB_G0293850	C	Seeded From UniProt	complete
enables	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1353494 MGI:MGI:1929955 PANTHER:PTN000198921 RGD:2092 RGD:708428 SGD:S000001146 SGD:S000002282 SGD:S000002776 SGD:S000003857 SGD:S000005646 UniProtKB:P15121 UniProtKB:P42330 UniProtKB:P52895 UniProtKB:Q04828 dictyBase:DDB_G0293850	F	Seeded From UniProt	complete
involved_in	GO:0006699	bile acid biosynthetic process	PMID:7508385^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018170 InterPro:IPR020471	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018170 InterPro:IPR020471	P	Seeded From UniProt	complete
enables	GO:0047787	delta4-3-oxosteroid 5beta-reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.3.1.3	F	Seeded From UniProt	complete
enables	GO:0005496	steroid binding	PMID:7508385^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006699	bile acid biosynthetic process	Reactome:R-HSA-193807 Reactome:R-HSA-193775 Reactome:R-HSA-193368	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-193824 Reactome:R-HSA-193821 Reactome:R-HSA-193755 Reactome:R-HSA-193746 Reactome:R-HSA-192067 Reactome:R-HSA-192033	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004033	aldo-keto reductase (NADP) activity	Reactome:R-HSA-193824 Reactome:R-HSA-193821 Reactome:R-HSA-193755 Reactome:R-HSA-193746 Reactome:R-HSA-192067 Reactome:R-HSA-192033	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P	Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0442	P	Seeded From UniProt	complete
involved_in	GO:0030573	bile acid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0088	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Kondo, KH et al. (1994) Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme. Eur. J. Biochem. 219 357-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7508385-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Kondo, KH et al. (1994) Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme. Eur. J. Biochem. 219 357-63 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:AKD1

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