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HUMAN:AIFM2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AIFM2 (synonyms: AMID, PRG3 (ECO:0000303 with PMID:12135761[1]))
Protein Name(s) Apoptosis-inducing factor 2

Apoptosis-inducing factor homologous mitochondrion-associated inducer of death Apoptosis-inducing factor-like mitochondrion-associated inducer of death p53-responsive gene 3 protein

External Links
UniProt Q9BRQ8
EMBL AF337957
AF506757
AK027403
AK127353
AL731540
CH471083
BC006121
BC023601
BX537621
CCDS CCDS7297.1
RefSeq NP_001185625.1
NP_116186.1
UniGene Hs.650680
ProteinModelPortal Q9BRQ8
SMR Q9BRQ8
BioGrid 124325
IntAct Q9BRQ8
STRING 9606.ENSP00000312370
PhosphoSite Q9BRQ8
DMDM 74752283
MaxQB Q9BRQ8
PaxDb Q9BRQ8
PRIDE Q9BRQ8
DNASU 84883
Ensembl ENST00000307864
ENST00000373248
ENST00000613322
GeneID 84883
KEGG hsa:84883
UCSC uc001jqp.2
CTD 84883
GeneCards GC10M071857
H-InvDB HIX0026110
HGNC HGNC:21411
HPA HPA042309
MIM 605159
neXtProt NX_Q9BRQ8
PharmGKB PA162376150
eggNOG COG1252
GeneTree ENSGT00390000004582
HOGENOM HOG000238788
HOVERGEN HBG054912
InParanoid Q9BRQ8
OMA PFTLVDM
OrthoDB EOG7J447T
PhylomeDB Q9BRQ8
TreeFam TF329369
ChiTaRS AIFM2
GeneWiki AIFM2
GenomeRNAi 84883
NextBio 75197
PRO PR:Q9BRQ8
Proteomes UP000005640
Bgee Q9BRQ8
CleanEx HS_AIFM2
HS_PRG3
Genevestigator Q9BRQ8
GO GO:0005737
GO:0005829
GO:0005615
GO:0016021
GO:0005811
GO:0005741
GO:0005739
GO:0003677
GO:0004174
GO:0050660
GO:0008137
GO:0008637
GO:0043065
InterPro IPR013027
IPR023753
IPR001327
IPR000103
Pfam PF00070
PF07992
PRINTS PR00368
PR00469

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016491

oxidoreductase activity

PMID:15958387[2]

ECO:0000314

F

Fig. 3 shows that AMID is a flavoprotein with NAD(P)H-dependent oxidoreductase activity.

complete

part_of

GO:0005615

extracellular space

PMID:22664934[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:15958387[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:11980907[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11980907[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005811

lipid droplet

PMID:14741744[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:11980907[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

PMID:15958387[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:15958387[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002464367
UniProtKB:Q9BRQ8

F

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002464374
UniProtKB:Q9BRQ8

P

Seeded From UniProt

complete

involved_in

GO:0008637

apoptotic mitochondrial changes

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002464374
UniProtKB:Q9BRQ8

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002464374
UniProtKB:Q9BRQ8

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002464367
UniProtKB:Q7S4Y9
UniProtKB:Q9BRQ8

C

Seeded From UniProt

complete

enables

GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002464367
UniProtKB:Q9BRQ8

F

Seeded From UniProt

complete

involved_in

GO:0008637

apoptotic mitochondrial changes

PMID:11980907[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:11980907[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12135761[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0022904

respiratory electron transport chain

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004174

P

Seeded From UniProt

complete

involved_in

GO:0022904

respiratory electron transport chain

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004174

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR023753

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR023753

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

Reactome:R-HSA-5633008

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

Reactome:R-HSA-6791306

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1000
UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Ohiro, Y et al. (2002) A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). FEBS Lett. 524 163-71 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Marshall, KR et al. (2005) The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity. J. Biol. Chem. 280 30735-40 PubMed GONUTS page
  3. ↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Wu, M et al. (2002) AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J. Biol. Chem. 277 25617-23 PubMed GONUTS page
  5. ↑ Fujimoto, Y et al. (2004) Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim. Biophys. Acta 1644 47-59 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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