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HUMAN:ACH10

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CHRNA10 (synonyms: NACHRA10)
Protein Name(s) Neuronal acetylcholine receptor subunit alpha-10

Nicotinic acetylcholine receptor subunit alpha-10 NACHR alpha-10

External Links
UniProt Q9GZZ6
EMBL AJ278118
AF199235
AF327367
AJ295237
CCDS CCDS7745.1
RefSeq NP_065135.2
UniGene Hs.732806
ProteinModelPortal Q9GZZ6
SMR Q9GZZ6
STRING 9606.ENSP00000250699
BindingDB Q9GZZ6
ChEMBL CHEMBL2109238
DrugBank DB01161
DB00674
DB00333
DB00184
DB01090
DB00202
DB01116
GuidetoPHARMACOLOGY 470
DMDM 14916526
PaxDb Q9GZZ6
PRIDE Q9GZZ6
DNASU 57053
Ensembl ENST00000250699
GeneID 57053
KEGG hsa:57053
UCSC uc001lyf.3
CTD 57053
GeneCards GC11M003699
HGNC HGNC:13800
HPA HPA060919
MIM 606372
neXtProt NX_Q9GZZ6
PharmGKB PA26488
eggNOG NOG306809
GeneTree ENSGT00760000118930
HOGENOM HOG000006756
HOVERGEN HBG003756
InParanoid Q9GZZ6
KO K04811
OMA CHQEALL
OrthoDB EOG72JWGV
PhylomeDB Q9GZZ6
TreeFam TF315605
GeneWiki CHRNA10
GenomeRNAi 57053
NextBio 62824
PRO PR:Q9GZZ6
Proteomes UP000005640
Bgee Q9GZZ6
CleanEx HS_CHRNA10
ExpressionAtlas Q9GZZ6
Genevestigator Q9GZZ6
GO GO:0005892
GO:0030424
GO:0030054
GO:0016020
GO:0043204
GO:0045211
GO:0004889
GO:0005262
GO:0005102
GO:0050910
GO:0042472
GO:0007204
GO:0042127
GO:0007271
Gene3D 1.20.120.370
2.70.170.10
InterPro IPR027361
IPR006202
IPR006201
IPR006029
IPR018000
IPR002394
PANTHER PTHR18945
Pfam PF02931
PF02932
PRINTS PR00254
PR00252
SUPFAM SSF63712
SSF90112
TIGRFAMs TIGR00860
PROSITE PS00236

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0050877

nervous system process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87888
PANTHER:PTN000434994
UniProtKB:P11230
UniProtKB:P17787
UniProtKB:P43681

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95747
PANTHER:PTN000434994
UniProtKB:G5EDF1
UniProtKB:P11230
WB:WBGene00006765
WB:WBGene00006774

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95747
PANTHER:PTN000434994
RGD:2351
RGD:621544
WB:WBGene00000042
WB:WBGene00002974
WB:WBGene00006765
WB:WBGene00006774

C

Seeded From UniProt

complete

involved_in

GO:0042391

regulation of membrane potential

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87885
MGI:MGI:87887
MGI:MGI:87888
MGI:MGI:87890
MGI:MGI:87891
MGI:MGI:87892
MGI:MGI:87893
MGI:MGI:87894
MGI:MGI:87895
MGI:MGI:95747
MGI:MGI:95751
MGI:MGI:99779
PANTHER:PTN000434994
RGD:2348
UniProtKB:P02708
UniProtKB:P23415

P

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95613
PANTHER:PTN000434994
UniProtKB:P23416
UniProtKB:P36544
UniProtKB:Q401N2
WB:WBGene00000055
WB:WBGene00002974
WB:WBGene00006797

P

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003011
FB:FBgn0086778
MGI:MGI:103156
MGI:MGI:95613
MGI:MGI:95623
MGI:MGI:95747
PANTHER:PTN000434994
RGD:2648
RGD:61859
RGD:61901
UniProtKB:P48167
WB:WBGene00000050
WB:WBGene00000054

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000434994
UniProtKB:P11230
UniProtKB:P17787
UniProtKB:P30926
UniProtKB:P32297
UniProtKB:P36544
UniProtKB:P43681
UniProtKB:Q15822

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861899
MGI:MGI:95623
MGI:MGI:95750
PANTHER:PTN000434994
RGD:2649
RGD:2650
RGD:61855
RGD:61861
RGD:621229
UniProtKB:O75311
UniProtKB:P23415
UniProtKB:P23416
UniProtKB:P28472
UniProtKB:P48167
UniProtKB:Q9UGM1
WB:WBGene00000955
WB:WBGene00001133
WB:WBGene00001591
WB:WBGene00001592

C

Seeded From UniProt

complete

contributes_to

GO:0005230

extracellular ligand-gated ion channel activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000434994
WB:WBGene00000043
WB:WBGene00001512
WB:WBGene00003386
WB:WBGene00006774
WB:WBGene00012857
WB:WBGene00017375

F

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:18420419[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9UGM1

P

Seeded From UniProt

complete

involved_in

GO:0060078

regulation of postsynaptic membrane potential

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0022848

P

Seeded From UniProt

complete

involved_in

GO:0060078

regulation of postsynaptic membrane potential

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0022848

P

Seeded From UniProt

complete

involved_in

GO:0060078

regulation of postsynaptic membrane potential

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:1904315

P

Seeded From UniProt

complete

involved_in

GO:0060079

excitatory postsynaptic potential

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0022848

P

Seeded From UniProt

complete

involved_in

GO:0060079

excitatory postsynaptic potential

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0022848

P

Seeded From UniProt

complete

involved_in

GO:0050910

detection of mechanical stimulus involved in sensory perception of sound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RX82
ensembl:ENSMUSP00000081891

P

Seeded From UniProt

complete

involved_in

GO:0042472

inner ear morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RX82
ensembl:ENSMUSP00000081891

P

Seeded From UniProt

complete

enables

GO:0022848

acetylcholine-gated cation-selective channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RX82
ensembl:ENSMUSP00000081891

F

Seeded From UniProt

complete

involved_in

GO:0007271

synaptic transmission, cholinergic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RX82
ensembl:ENSMUSP00000081891

P

Seeded From UniProt

complete

enables

GO:1904315

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JLB5
ensembl:ENSRNOP00000027506

F

Seeded From UniProt

complete

part_of

GO:0099060

integral component of postsynaptic specialization membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JLB5
ensembl:ENSRNOP00000027506

C

Seeded From UniProt

complete

part_of

GO:0098981

cholinergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JLB5
ensembl:ENSRNOP00000027506

C

Seeded From UniProt

complete

involved_in

GO:0070373

negative regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JLB5
ensembl:ENSRNOP00000027506

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JLB5
ensembl:ENSRNOP00000027506

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JLB5
ensembl:ENSRNOP00000027506

C

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006201

F

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002394
InterPro:IPR006201

F

Seeded From UniProt

complete

enables

GO:0005230

extracellular ligand-gated ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006202
InterPro:IPR036734

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002394
InterPro:IPR006029
InterPro:IPR006202
InterPro:IPR036719
InterPro:IPR036734

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002394
InterPro:IPR006029
InterPro:IPR006201
InterPro:IPR006202
InterPro:IPR036719
InterPro:IPR036734

C

Seeded From UniProt

complete

enables

GO:0022848

acetylcholine-gated cation-selective channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002394

F

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006201

P

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002394

C

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

PMID:11350119[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:11350119[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007271

synaptic transmission, cholinergic

PMID:11350119[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:11350119[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0628
UniProtKB-SubCell:SL-0219

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0107

F

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0107

P

Seeded From UniProt

complete

involved_in

GO:0006816

calcium ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0109

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Osman, AA et al. (2008) Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Mol. Cell. Neurosci. 38 153-69 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Lustig, LR et al. (2001) Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). Genomics 73 272-83 PubMed GONUTS page
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