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HUMAN:ACACA

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ACACA (synonyms: ACAC, ACC1, ACCA)
Protein Name(s) Acetyl-CoA carboxylase 1

ACC1 ACC-alpha Biotin carboxylase

External Links
UniProt Q13085
EMBL U19822
AY315619
AY315620
AY315621
AY315623
AY315625
AY315627
AY237919
BC137287
AJ534888
AJ534889
AJ564444
CCDS CCDS11317.1
CCDS11318.1
CCDS42302.1
CCDS42303.1
PIR I38928
RefSeq NP_942131.1
NP_942133.1
NP_942134.1
NP_942135.1
NP_942136.1
UniGene Hs.160556
PDB 2YL2
3COJ
4ASI
PDBsum 2YL2
3COJ
4ASI
ProteinModelPortal Q13085
SMR Q13085
BioGrid 106549
DIP DIP-36122N
IntAct Q13085
MINT MINT-1415014
BindingDB Q13085
ChEMBL CHEMBL3351
DrugBank DB00121
GuidetoPHARMACOLOGY 1263
PhosphoSite Q13085
DMDM 118601083
MaxQB Q13085
PaxDb Q13085
PRIDE Q13085
Ensembl ENST00000611803
ENST00000612895
ENST00000613687
ENST00000614428
ENST00000616317
ENST00000616352
ENST00000617649
ENST00000619487
ENST00000621312
GeneID 31
KEGG hsa:31
UCSC uc002hnk.3
uc002hnl.3
uc002hno.3
CTD 31
GeneCards GC17M035441
HGNC HGNC:84
HPA CAB013715
MIM 200350
613933
neXtProt NX_Q13085
PharmGKB PA24421
eggNOG COG0511
GeneTree ENSGT00550000074703
HOVERGEN HBG005371
InParanoid Q13085
KO K11262
OMA GESGCIH
OrthoDB EOG7HXCPW
PhylomeDB Q13085
TreeFam TF300061
BRENDA 6.4.1.2
Reactome REACT_11082
REACT_11153
REACT_1319
REACT_147904
REACT_169312
REACT_2122
SABIO-RK Q13085
UniPathway UPA00655
ChiTaRS ACACA
EvolutionaryTrace Q13085
GeneWiki ACACA
GenomeRNAi 31
NextBio 111
PRO PR:Q13085
Proteomes UP000005640
UP000005640
Bgee Q13085
ExpressionAtlas Q13085
Genevestigator Q13085
GO GO:0005829
GO:0070062
GO:0005739
GO:0003989
GO:0005524
GO:0004075
GO:0046872
GO:0006084
GO:0006768
GO:0006853
GO:0044255
GO:0006112
GO:0006633
GO:0055088
GO:0035338
GO:2001295
GO:0044268
GO:0031325
GO:0051289
GO:0044281
GO:0001894
GO:0019432
GO:0006766
GO:0006767
Gene3D 3.30.1490.20
3.30.470.20
3.40.50.20
3.90.226.10
InterPro IPR013537
IPR011761
IPR013815
IPR013816
IPR001882
IPR011764
IPR005482
IPR000089
IPR005481
IPR000022
IPR005479
IPR029045
IPR011763
IPR011762
IPR016185
IPR011054
IPR011053
Pfam PF08326
PF02785
PF00364
PF01039
PF00289
PF02786
SMART SM00878
SUPFAM SSF51230
SSF51246
SSF52096
SSF52440
PROSITE PS50975
PS50979
PS00188
PS50968
PS50989
PS50980
PS00866
PS00867

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032868

response to insulin stimulus

PMID:20139635[1]

ECO:0000315

P

Fig.4

complete

GO:0071548

response to dexamethasone stimulus

PMID:20139635[1]

ECO:0000315

P

Fig.3

complete

involved_in

GO:0051289

protein homotetramerization

PMID:20952656[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5SWU9

P

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5SWU9

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5SWU9

P

Seeded From UniProt

complete

involved_in

GO:0006084

acetyl-CoA metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5SWU9

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5SWU9

C

Seeded From UniProt

complete

enables

GO:0003989

acetyl-CoA carboxylase activity

PMID:20952656[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5SWU9

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:20457939[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13085

F

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0001650

fibrillar center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071380

cellular response to prostaglandin E stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5SWU9
ensembl:ENSMUSP00000099490

P

Seeded From UniProt

complete

involved_in

GO:0055088

lipid homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5SWU9
ensembl:ENSMUSP00000099490

P

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5SWU9
ensembl:ENSMUSP00000099490

P

Seeded From UniProt

complete

involved_in

GO:0019538

protein metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5SWU9
ensembl:ENSMUSP00000099490

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5SWU9
ensembl:ENSMUSP00000099490

P

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5SWU9
ensembl:ENSMUSP00000099490

P

Seeded From UniProt

complete

involved_in

GO:0006084

acetyl-CoA metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5SWU9
ensembl:ENSMUSP00000099490

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5SWU9
ensembl:ENSMUSP00000099490

C

Seeded From UniProt

complete

enables

GO:0003989

acetyl-CoA carboxylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5SWU9
ensembl:ENSMUSP00000099490

F

Seeded From UniProt

complete

involved_in

GO:0001894

tissue homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5SWU9
ensembl:ENSMUSP00000099490

P

Seeded From UniProt

complete

enables

GO:0003989

acetyl-CoA carboxylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013537

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005479
InterPro:IPR011761
InterPro:IPR013537
InterPro:IPR013815

F

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013537

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011763

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011761

F

Seeded From UniProt

complete

enables

GO:0004075

biotin carboxylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.3.4.14

F

Seeded From UniProt

complete

enables

GO:0003989

acetyl-CoA carboxylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.4.1.2

F

Seeded From UniProt

complete

enables

GO:0003989

acetyl-CoA carboxylase activity

PMID:7905825[4]
Reactome:R-HSA-200555

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0046949

fatty-acyl-CoA biosynthetic process

Reactome:R-HSA-75105

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045540

regulation of cholesterol biosynthetic process

Reactome:R-HSA-1655829

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031325

positive regulation of cellular metabolic process

Reactome:R-HSA-163765

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006853

carnitine shuttle

Reactome:R-HSA-200425

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-75851
Reactome:R-HSA-3323184
Reactome:R-HSA-3065958
Reactome:R-HSA-2993814
Reactome:R-HSA-200555
Reactome:R-HSA-1655845
Reactome:R-HSA-163743

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511
UniProtKB-KW:KW-0021

F

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021
UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:2001295

malonyl-CoA biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00655

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Zhao, LF et al. (2010) Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Endocr. J. 57 317-24 PubMed GONUTS page
  2. ↑ 2.0 2.1 Colbert, CL et al. (2010) Crystal structure of Spot 14, a modulator of fatty acid synthesis. Proc. Natl. Acad. Sci. U.S.A. 107 18820-5 PubMed GONUTS page
  3. ↑ Kim, CW et al. (2010) Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proc. Natl. Acad. Sci. U.S.A. 107 9626-31 PubMed GONUTS page
  4. ↑ Ha, J et al. (1994) Cloning of human acetyl-CoA carboxylase cDNA. Eur. J. Biochem. 219 297-306 PubMed GONUTS page
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