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HUMAN:ACACA
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | ACACA (synonyms: ACAC, ACC1, ACCA) | |
Protein Name(s) | Acetyl-CoA carboxylase 1
ACC1 ACC-alpha Biotin carboxylase | |
External Links | ||
UniProt | Q13085 | |
EMBL | U19822 AY315619 AY315620 AY315621 AY315623 AY315625 AY315627 AY237919 BC137287 AJ534888 AJ534889 AJ564444 | |
CCDS | CCDS11317.1 CCDS11318.1 CCDS42302.1 CCDS42303.1 | |
PIR | I38928 | |
RefSeq | NP_942131.1 NP_942133.1 NP_942134.1 NP_942135.1 NP_942136.1 | |
UniGene | Hs.160556 | |
PDB | 2YL2 3COJ 4ASI | |
PDBsum | 2YL2 3COJ 4ASI | |
ProteinModelPortal | Q13085 | |
SMR | Q13085 | |
BioGrid | 106549 | |
DIP | DIP-36122N | |
IntAct | Q13085 | |
MINT | MINT-1415014 | |
BindingDB | Q13085 | |
ChEMBL | CHEMBL3351 | |
DrugBank | DB00121 | |
GuidetoPHARMACOLOGY | 1263 | |
PhosphoSite | Q13085 | |
DMDM | 118601083 | |
MaxQB | Q13085 | |
PaxDb | Q13085 | |
PRIDE | Q13085 | |
Ensembl | ENST00000611803 ENST00000612895 ENST00000613687 ENST00000614428 ENST00000616317 ENST00000616352 ENST00000617649 ENST00000619487 ENST00000621312 | |
GeneID | 31 | |
KEGG | hsa:31 | |
UCSC | uc002hnk.3 uc002hnl.3 uc002hno.3 | |
CTD | 31 | |
GeneCards | GC17M035441 | |
HGNC | HGNC:84 | |
HPA | CAB013715 | |
MIM | 200350 613933 | |
neXtProt | NX_Q13085 | |
PharmGKB | PA24421 | |
eggNOG | COG0511 | |
GeneTree | ENSGT00550000074703 | |
HOVERGEN | HBG005371 | |
InParanoid | Q13085 | |
KO | K11262 | |
OMA | GESGCIH | |
OrthoDB | EOG7HXCPW | |
PhylomeDB | Q13085 | |
TreeFam | TF300061 | |
BRENDA | 6.4.1.2 | |
Reactome | REACT_11082 REACT_11153 REACT_1319 REACT_147904 REACT_169312 REACT_2122 | |
SABIO-RK | Q13085 | |
UniPathway | UPA00655 | |
ChiTaRS | ACACA | |
EvolutionaryTrace | Q13085 | |
GeneWiki | ACACA | |
GenomeRNAi | 31 | |
NextBio | 111 | |
PRO | PR:Q13085 | |
Proteomes | UP000005640 UP000005640 | |
Bgee | Q13085 | |
ExpressionAtlas | Q13085 | |
Genevestigator | Q13085 | |
GO | GO:0005829 GO:0070062 GO:0005739 GO:0003989 GO:0005524 GO:0004075 GO:0046872 GO:0006084 GO:0006768 GO:0006853 GO:0044255 GO:0006112 GO:0006633 GO:0055088 GO:0035338 GO:2001295 GO:0044268 GO:0031325 GO:0051289 GO:0044281 GO:0001894 GO:0019432 GO:0006766 GO:0006767 | |
Gene3D | 3.30.1490.20 3.30.470.20 3.40.50.20 3.90.226.10 | |
InterPro | IPR013537 IPR011761 IPR013815 IPR013816 IPR001882 IPR011764 IPR005482 IPR000089 IPR005481 IPR000022 IPR005479 IPR029045 IPR011763 IPR011762 IPR016185 IPR011054 IPR011053 | |
Pfam | PF08326 PF02785 PF00364 PF01039 PF00289 PF02786 | |
SMART | SM00878 | |
SUPFAM | SSF51230 SSF51246 SSF52096 SSF52440 | |
PROSITE | PS50975 PS50979 PS00188 PS50968 PS50989 PS50980 PS00866 PS00867 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0032868 |
response to insulin stimulus |
ECO:0000315 |
P |
Fig.4 |
complete | |||||
GO:0071548 |
response to dexamethasone stimulus |
ECO:0000315 |
P |
Fig.3 |
complete | |||||
involved_in |
GO:0051289 |
protein homotetramerization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051289 |
protein homotetramerization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006084 |
acetyl-CoA metabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0015629 |
actin cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0001650 |
fibrillar center |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071380 |
cellular response to prostaglandin E stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SWU9 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055088 |
lipid homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SWU9 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051289 |
protein homotetramerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SWU9 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019538 |
protein metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SWU9 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SWU9 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SWU9 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006084 |
acetyl-CoA metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SWU9 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SWU9 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SWU9 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001894 |
tissue homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SWU9 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR005479 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016874 |
ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004075 |
biotin carboxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
PMID:7905825[4] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
involved_in |
GO:0046949 |
fatty-acyl-CoA biosynthetic process |
Reactome:R-HSA-75105 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045540 |
regulation of cholesterol biosynthetic process |
Reactome:R-HSA-1655829 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031325 |
positive regulation of cellular metabolic process |
Reactome:R-HSA-163765 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006853 |
carnitine shuttle |
Reactome:R-HSA-200425 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-75851 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001295 |
malonyl-CoA biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00655 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Zhao, LF et al. (2010) Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Endocr. J. 57 317-24 PubMed GONUTS page
- ↑ 2.0 2.1 Colbert, CL et al. (2010) Crystal structure of Spot 14, a modulator of fatty acid synthesis. Proc. Natl. Acad. Sci. U.S.A. 107 18820-5 PubMed GONUTS page
- ↑ Kim, CW et al. (2010) Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proc. Natl. Acad. Sci. U.S.A. 107 9626-31 PubMed GONUTS page
- ↑ Ha, J et al. (1994) Cloning of human acetyl-CoA carboxylase cDNA. Eur. J. Biochem. 219 297-306 PubMed GONUTS page
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