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HUMAN:ABEC1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | APOBEC1 | |
| Protein Name(s) | C->U-editing enzyme APOBEC-1
Apolipoprotein B mRNA-editing enzyme 1 HEPR | |
| External Links | ||
| UniProt | P41238 | |
| EMBL | L25877 L26234 U72891 AB009426 U78720 | |
| CCDS | CCDS8579.1 | |
| PIR | I59323 | |
| RefSeq | NP_001635.2 XP_005253412.1 | |
| UniGene | Hs.560 | |
| ProteinModelPortal | P41238 | |
| SMR | P41238 | |
| BioGrid | 106836 | |
| STRING | 9606.ENSP00000229304 | |
| PhosphoSite | P41238 | |
| DMDM | 152013530 | |
| PaxDb | P41238 | |
| PRIDE | P41238 | |
| Ensembl | ENST00000229304 | |
| GeneID | 339 | |
| KEGG | hsa:339 | |
| UCSC | uc001qtb.3 | |
| CTD | 339 | |
| GeneCards | GC12M007801 | |
| HGNC | HGNC:604 | |
| MIM | 600130 | |
| neXtProt | NX_P41238 | |
| PharmGKB | PA24889 | |
| eggNOG | NOG41905 | |
| GeneTree | ENSGT00530000062933 | |
| HOGENOM | HOG000033766 | |
| HOVERGEN | HBG050445 | |
| KO | K16932 | |
| OMA | NFVNYPP | |
| OrthoDB | EOG7NGQCB | |
| PhylomeDB | P41238 | |
| TreeFam | TF331356 | |
| Reactome | REACT_1390 REACT_167 | |
| GeneWiki | APOBEC1 | |
| GenomeRNAi | 339 | |
| NextBio | 1403 | |
| PRO | PR:P41238 | |
| Proteomes | UP000005640 | |
| Bgee | P41238 | |
| CleanEx | HS_APOBEC1 | |
| Genevestigator | P41238 | |
| GO | GO:0005737 GO:0005654 GO:0017091 GO:0004126 GO:0003723 GO:0008270 GO:0032869 GO:0009972 GO:0016554 GO:0051607 GO:0080111 GO:0010467 GO:0006629 GO:0042158 GO:0042953 GO:0016556 GO:0006397 GO:0048255 GO:0090310 GO:0042127 GO:0051592 GO:0042493 GO:0045471 GO:0010332 GO:0006970 GO:0010043 GO:0006396 | |
| InterPro | IPR016192 IPR013158 IPR016193 | |
| Pfam | PF08210 | |
| SUPFAM | SSF53927 | |
| PROSITE | PS00903 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0090310 |
negative regulation of methylation-dependent chromatin silencing |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0080111 |
DNA demethylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0080111 |
DNA demethylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103298 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016554 |
cytidine to uridine editing |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103298 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1933111 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000355219 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004126 |
cytidine deaminase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1342279 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000355219 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009972 |
cytidine deamination |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004126 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009972 |
cytidine deamination |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004126 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009972 |
cytidine deamination |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004126 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009972 |
cytidine deamination |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004126 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043085 |
positive regulation of catalytic activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008047 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090366 |
positive regulation of mRNA modification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070383 |
DNA cytosine deamination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051592 |
response to calcium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045471 |
response to ethanol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043021 |
ribonucleoprotein complex binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016556 |
mRNA modification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016554 |
cytidine to uridine editing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010043 |
response to zinc ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008047 |
enzyme activator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006970 |
response to osmotic stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004131 |
cytosine deaminase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004126 |
cytidine deaminase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P38483 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090310 |
negative regulation of methylation-dependent chromatin silencing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090209 |
negative regulation of triglyceride metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080111 |
DNA demethylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048255 |
mRNA stabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042953 |
lipoprotein transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042158 |
lipoprotein biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042157 |
lipoprotein metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035925 |
mRNA 3'-UTR AU-rich region binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016556 |
mRNA modification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016554 |
cytidine to uridine editing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010332 |
response to gamma radiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006641 |
triglyceride metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51908 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006396 |
RNA processing |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004126 |
cytidine deaminase activity |
PMID:7736571[3] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
|
enables |
GO:0003723 |
RNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016554 |
cytidine to uridine editing |
Reactome:R-HSA-72200 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-83677 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Sun, H et al. (2012) Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor. Arterioscler. Thromb. Vasc. Biol. 32 1585-95 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Navaratnam, N et al. (1995) Evolutionary origins of apoB mRNA editing: catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site. Cell 81 187-95 PubMed GONUTS page
- ↑ Lau, PP et al. (1994) Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. Proc. Natl. Acad. Sci. U.S.A. 91 8522-6 PubMed GONUTS page
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- GO:0042127 ! regulation of cell population proliferation
- GO:0051592 ! response to calcium ion
- GO:0045471 ! response to ethanol
- GO:0042493 ! response to drug
- GO:0006970 ! response to osmotic stress
- GO:0010332 ! response to gamma radiation
- GO:0010043 ! response to zinc ion
- GO:0043021 ! ribonucleoprotein complex binding
- GO:0003723 ! RNA binding
- GO:0006396 ! RNA processing
