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HUMAN:ABCG2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ABCG2 (synonyms: ABCP, BCRP, BCRP1, MXR)
Protein Name(s) ATP-binding cassette sub-family G member 2

Breast cancer resistance protein CDw338 Mitoxantrone resistance-associated protein Placenta-specific ATP-binding cassette transporter Urate exporter

External Links
UniProt Q9UNQ0
EMBL AF103796
AF098951
AB056867
AB051855
AY017168
AY289766
AY288307
AF463519
AY333755
AY333756
AK002040
AK290000
DQ996467
AC084732
AC097484
BC021281
BC092408
AF093771
AF093772
CCDS CCDS3628.1
CCDS58910.1
RefSeq NP_001244315.1
NP_004818.2
XP_005263411.1
XP_005263412.1
UniGene Hs.480218
ProteinModelPortal Q9UNQ0
SMR Q9UNQ0
BioGrid 114821
DIP DIP-29162N
IntAct Q9UNQ0
MINT MINT-2840423
BindingDB Q9UNQ0
ChEMBL CHEMBL5393
DrugBank DB08916
DB06605
DB00921
DB06772
DB00958
DB00515
DB00242
DB00631
DB00286
DB00091
DB08912
DB00970
DB01254
DB00694
DB01234
DB00255
DB01248
DB00997
DB00470
DB00530
DB00783
DB00655
DB00773
DB00973
DB00544
DB00158
DB00317
DB01016
DB01094
DB00741
DB00619
DB00762
DB00602
DB00709
DB00448
DB01097
DB00563
DB01204
DB00688
DB00220
DB04868
DB00698
DB01051
DB00338
DB00526
DB01229
DB00213
DB06589
DB08860
DB08901
DB00175
DB00457
DB01129
DB08896
DB08864
DB00740
DB00503
DB01098
DB01232
DB00398
DB00795
DB00669
DB01268
DB00675
DB00966
DB00444
DB08880
DB00624
DB01030
DB05294
DB08881
DB00285
DB00661
DB00541
DB08828
DB00549
DB00495
TCDB 3.A.1.204.2
PhosphoSite Q9UNQ0
DMDM 67462103
MaxQB Q9UNQ0
PaxDb Q9UNQ0
PRIDE Q9UNQ0
DNASU 9429
Ensembl ENST00000237612
ENST00000515655
GeneID 9429
KEGG hsa:9429
UCSC uc003hrf.3
uc003hrh.3
CTD 9429
GeneCards GC04M089011
HGNC HGNC:74
HPA CAB037299
HPA054719
MIM 138900
603756
614490
neXtProt NX_Q9UNQ0
PharmGKB PA390
eggNOG COG1131
GeneTree ENSGT00740000114855
HOVERGEN HBG050441
InParanoid Q9UNQ0
KO K05681
OMA FYKETKA
OrthoDB EOG7HXCR2
PhylomeDB Q9UNQ0
TreeFam TF105211
Reactome REACT_120801
REACT_25060
ChiTaRS ABCG2
GeneWiki ABCG2
GenomeRNAi 9429
NextBio 35322
PRO PR:Q9UNQ0
Proteomes UP000005640
Bgee Q9UNQ0
ExpressionAtlas Q9UNQ0
Genevestigator Q9UNQ0
GO GO:0016021
GO:0031966
GO:0005654
GO:0005634
GO:0005886
GO:0005524
GO:0042626
GO:0015232
GO:0042803
GO:0005215
GO:0008559
GO:0006879
GO:0006855
GO:0015886
GO:0042493
GO:0044281
GO:0055085
GO:0006810
GO:0046415
GO:0042908
Gene3D 3.40.50.300
InterPro IPR003593
IPR013525
IPR003439
IPR030256
IPR027417
PANTHER PTHR19241:SF198
Pfam PF01061
PF00005
SMART SM00382
SUPFAM SSF52540
PROSITE PS50893

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0055085

transmembrane transport

PMID:25793771[1]

ECO:0000316

UniProtKB:Q9UNQ0


P

Figure 2 displayed how the expression level of ABCG2 was already altered in mild/moderate dysplasia in carcinogenesis

complete
CACAO 10876

involved_in

GO:1990748

cellular detoxification

PMID:9861027[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008559

xenobiotic transmembrane transporting ATPase activity

PMID:9861027[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046415

urate metabolic process

PMID:19503597[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:16870176[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046415

urate metabolic process

PMID:20053405[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046415

urate metabolic process

PMID:18834626[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003996
FB:FBgn0020762
PANTHER:PTN000443108
TAIR:locus:2084081

P

Seeded From UniProt

complete

enables

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020762
PANTHER:PTN000443108
TAIR:locus:2016089
UniProtKB:Q9H221
UniProtKB:Q9H222

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000443108
PomBase:SPCC18B5.01c
RGD:631345
SGD:S000002418
SGD:S000005537
SGD:S000005679
SGD:S000005855
SGD:S000005979
TAIR:locus:2009680
TAIR:locus:2016089
TAIR:locus:2019693
TAIR:locus:2028656
TAIR:locus:2030898
TAIR:locus:2037703
TAIR:locus:2039523
TAIR:locus:2039682
TAIR:locus:2044893
TAIR:locus:2046203
TAIR:locus:2049867
TAIR:locus:2084081
TAIR:locus:2090009
TAIR:locus:2100514
TAIR:locus:2124029
TAIR:locus:2144133
TAIR:locus:2196593
UniProtKB:A0A1D8PCM6
UniProtKB:A0A1D8PE84
UniProtKB:A0A1D8PQ95
UniProtKB:E9RBG1
UniProtKB:Q4X006
UniProtKB:Q8H8V7
UniProtKB:Q94A18
UniProtKB:Q9UNQ0

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:20399185[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UNQ0

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:19506252[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UNQ0

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:17098188[10]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UNQ0

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16870176[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UNQ0

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006855

drug transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008559

P

Seeded From UniProt

complete

involved_in

GO:0042908

xenobiotic transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008559

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003439
InterPro:IPR030256

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013525

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030256

C

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003439

F

Seeded From UniProt

complete

enables

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030256

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030256

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:29610494[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UNQ0-1

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:28554189[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UNQ0-1

F

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

Reactome:R-HSA-917937

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-917979

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0171

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Andersen, V et al. (2015) High ABCC2 and low ABCG2 gene expression are early events in the colorectal adenoma-carcinoma sequence. PLoS ONE 10 e0119255 PubMed GONUTS page
  2. ↑ 2.0 2.1 Doyle, LA et al. (1998) A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 95 15665-70 PubMed GONUTS page
  3. ↑ Kolz, M et al. (2009) Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 5 e1000504 PubMed GONUTS page
  4. ↑ 4.0 4.1 Engel, T et al. (2006) Expression and functional characterization of ABCG1 splice variant ABCG1(666). FEBS Lett. 580 4551-9 PubMed GONUTS page
  5. ↑ Brandstätter, A et al. (2010) Sex and age interaction with genetic association of atherogenic uric acid concentrations. Atherosclerosis 210 474-8 PubMed GONUTS page
  6. ↑ Dehghan, A et al. (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 372 1953-61 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ Rosenberg, MF et al. (2010) The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone. Structure 18 482-93 PubMed GONUTS page
  9. ↑ Woodward, OM et al. (2009) Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc. Natl. Acad. Sci. U.S.A. 106 10338-42 PubMed GONUTS page
  10. ↑ McDevitt, CA et al. (2006) Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2. Structure 14 1623-32 PubMed GONUTS page
  11. ↑ Jackson, SM et al. (2018) Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol. 25 333-340 PubMed GONUTS page
  12. ↑ Taylor, NMI et al. (2017) Structure of the human multidrug transporter ABCG2. Nature 546 504-509 PubMed GONUTS page
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