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HUMAN:AAKG2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PRKAG2 | |
| Protein Name(s) | 5'-AMP-activated protein kinase subunit gamma-2
AMPK gamma2 AMPK subunit gamma-2 H91620p | |
| External Links | ||
| UniProt | Q9UGJ0 | |
| EMBL | AB025580 AJ249976 AF087875 AK001887 BT007127 AC006358 AC006966 AC093583 BC020540 BC068598 | |
| CCDS | CCDS43683.1 CCDS47752.1 CCDS5928.1 | |
| RefSeq | NP_001035723.1 NP_057287.2 NP_077747.1 | |
| UniGene | Hs.647072 | |
| ProteinModelPortal | Q9UGJ0 | |
| SMR | Q9UGJ0 | |
| BioGrid | 119531 | |
| IntAct | Q9UGJ0 | |
| MINT | MINT-4831646 | |
| STRING | 9606.ENSP00000287878 | |
| ChEMBL | CHEMBL2096907 | |
| DrugBank | DB00945 | |
| PhosphoSite | Q9UGJ0 | |
| DMDM | 14285344 | |
| MaxQB | Q9UGJ0 | |
| PaxDb | Q9UGJ0 | |
| PRIDE | Q9UGJ0 | |
| DNASU | 51422 | |
| Ensembl | ENST00000287878 ENST00000392801 ENST00000418337 | |
| GeneID | 51422 | |
| KEGG | hsa:51422 | |
| UCSC | uc003wki.3 | |
| CTD | 51422 | |
| GeneCards | GC07M151253 | |
| GeneReviews | PRKAG2 | |
| HGNC | HGNC:9386 | |
| HPA | CAB018641 HPA004246 | |
| MIM | 194200 261740 600858 602743 | |
| neXtProt | NX_Q9UGJ0 | |
| Orphanet | 155 907 | |
| PharmGKB | PA33752 | |
| eggNOG | COG0517 | |
| GeneTree | ENSGT00390000009849 | |
| HOVERGEN | HBG050431 | |
| KO | K07200 | |
| OMA | XVQIYEL | |
| OrthoDB | EOG74FF0W | |
| PhylomeDB | Q9UGJ0 | |
| TreeFam | TF313247 | |
| Reactome | REACT_11082 REACT_147867 REACT_1988 REACT_200686 REACT_21285 REACT_21393 | |
| SignaLink | Q9UGJ0 | |
| ChiTaRS | PRKAG2 | |
| GeneWiki | PRKAG2 | |
| GenomeRNAi | 51422 | |
| NextBio | 54969 | |
| PRO | PR:Q9UGJ0 | |
| Proteomes | UP000005640 | |
| Bgee | Q9UGJ0 | |
| CleanEx | HS_PRKAG2 | |
| ExpressionAtlas | Q9UGJ0 | |
| Genevestigator | Q9UGJ0 | |
| GO | GO:0031588 GO:0005829 GO:0005615 GO:0005654 GO:0043531 GO:0016208 GO:0004679 GO:0005524 GO:0004862 GO:0008603 GO:0008607 GO:0030295 GO:0019901 GO:0006754 GO:0006853 GO:0007050 GO:0044255 GO:0006112 GO:0006633 GO:0005977 GO:0008286 GO:0035556 GO:0061024 GO:0006469 GO:0071901 GO:0010800 GO:0045860 GO:0042304 GO:0019217 GO:0046320 GO:0046324 GO:0006110 GO:0044281 GO:0016126 | |
| InterPro | IPR000644 | |
| Pfam | PF00571 | |
| SMART | SM00116 | |
| PROSITE | PS51371 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001827) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045860 |
positive regulation of protein kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043531 |
ADP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031588 |
nucleotide-activated protein kinase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030295 |
protein kinase activator activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019217 |
regulation of fatty acid metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008607 |
phosphorylase kinase regulator activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008603 |
cAMP-dependent protein kinase regulator activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006110 |
regulation of glycolytic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005977 |
glycogen metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005977 |
glycogen metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004862 |
cAMP-dependent protein kinase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004679 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032147 |
activation of protein kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0030295 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071901 |
negative regulation of protein serine/threonine kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004862 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050790 |
regulation of catalytic activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A140UHX4 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031588 |
nucleotide-activated protein kinase complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A140UHX4 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A140UHX4 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016208 |
AMP binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A140UHX4 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004679 |
AMP-activated protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A140UHX4 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0032559 |
adenyl ribonucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071900 |
regulation of protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046324 |
regulation of glucose import |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046320 |
regulation of fatty acid oxidation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016126 |
sterol biosynthetic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006754 |
ATP biosynthetic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901796 |
regulation of signal transduction by p53 class mediator |
Reactome:R-HSA-5633007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042304 |
regulation of fatty acid biosynthetic process |
Reactome:R-HSA-163680 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016241 |
regulation of macroautophagy |
Reactome:R-HSA-5673768 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016236 |
macroautophagy |
Reactome:R-HSA-1632852 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007050 |
cell cycle arrest |
Reactome:R-HSA-380972 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006853 |
carnitine shuttle |
Reactome:R-HSA-200425 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5679239 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6805470 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Burwinkel, B et al. (2005) Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. Am. J. Hum. Genet. 76 1034-49 PubMed GONUTS page
- ↑ Cheung, PC et al. (2000) Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem. J. 346 Pt 3 659-69 PubMed GONUTS page
- ↑ 4.0 4.1 Scott, JW et al. (2007) Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit. EMBO J. 26 806-15 PubMed GONUTS page
- ↑ 5.0 5.1 Arad, M et al. (2002) Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. J. Clin. Invest. 109 357-62 PubMed GONUTS page
- ↑ 6.0 6.1 Hardie, DG & Carling, D (1997) The AMP-activated protein kinase--fuel gauge of the mammalian cell? Eur. J. Biochem. 246 259-73 PubMed GONUTS page
- ↑ Blair, E et al. (2001) Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis. Hum. Mol. Genet. 10 1215-20 PubMed GONUTS page
a
c
n
p
- GO:0008607 ! phosphorylase kinase regulator activity
- GO:0045860 ! positive regulation of protein kinase activity
- GO:0010800 ! positive regulation of peptidyl-threonine phosphorylation
- Primates
- GO:0030295 ! protein kinase activator activity
- GO:0019901 ! protein kinase binding
- GO:0006468 ! protein phosphorylation
r
- GO:0046324 ! regulation of D-glucose import
- GO:0071900 ! regulation of protein serine/threonine kinase activity
- GO:0046320 ! regulation of fatty acid oxidation
- GO:0042304 ! regulation of fatty acid biosynthetic process
- GO:0019217 ! regulation of fatty acid metabolic process
- GO:0016241 ! regulation of macroautophagy
- GO:0006110 ! regulation of glycolytic process
- GO:1901796 ! regulation of signal transduction by p53 class mediator
- GO:0050790 ! regulation of catalytic activity
