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HUMAN:5HT3C
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | HTR3C | |
| Protein Name(s) | 5-hydroxytryptamine receptor 3C
5-HT3-C 5-HT3C Serotonin receptor 3C | |
| External Links | ||
| UniProt | Q8WXA8 | |
| EMBL | AF459285 CH471052 BC131799 | |
| CCDS | CCDS3250.1 | |
| RefSeq | NP_570126.2 | |
| UniGene | Hs.632579 | |
| ProteinModelPortal | Q8WXA8 | |
| SMR | Q8WXA8 | |
| BioGrid | 128062 | |
| STRING | 9606.ENSP00000322617 | |
| BindingDB | Q8WXA8 | |
| ChEMBL | CHEMBL2094132 | |
| DrugBank | DB01049 | |
| GuidetoPHARMACOLOGY | 375 | |
| DMDM | 166198366 | |
| PaxDb | Q8WXA8 | |
| PRIDE | Q8WXA8 | |
| Ensembl | ENST00000318351 | |
| GeneID | 170572 | |
| KEGG | hsa:170572 | |
| UCSC | uc003fmk.3 | |
| CTD | 170572 | |
| GeneCards | GC03P183770 | |
| HGNC | HGNC:24003 | |
| MIM | 610121 | |
| neXtProt | NX_Q8WXA8 | |
| PharmGKB | PA134925741 | |
| eggNOG | NOG316889 | |
| GeneTree | ENSGT00770000120477 | |
| HOGENOM | HOG000241519 | |
| HOVERGEN | HBG106638 | |
| InParanoid | Q8WXA8 | |
| KO | K04819 | |
| OMA | DIFIMES | |
| OrthoDB | EOG7XPZ5D | |
| PhylomeDB | Q8WXA8 | |
| TreeFam | TF315605 | |
| Reactome | REACT_25387 | |
| GeneWiki | HTR3C | |
| GenomeRNAi | 170572 | |
| NextBio | 89041 | |
| PRO | PR:Q8WXA8 | |
| Proteomes | UP000005640 | |
| Bgee | Q8WXA8 | |
| CleanEx | HS_HTR3C | |
| Genevestigator | Q8WXA8 | |
| GO | GO:0016021 GO:0005886 GO:0005230 GO:0034220 GO:0055085 | |
| Gene3D | 1.20.120.370 2.70.170.10 | |
| InterPro | IPR027361 IPR006202 IPR006201 IPR006029 IPR018000 | |
| PANTHER | PTHR18945 | |
| Pfam | PF02931 PF02932 | |
| PRINTS | PR00252 | |
| SUPFAM | SSF63712 SSF90112 | |
| PROSITE | PS00236 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0022850 |
serotonin-gated cation-selective channel activity |
ECO:0000314 |
F |
Figure 5 illustrates a concentration-response curve where the percent of maximal response from the 5HT3C subunit increased when presented with agonists 5-HT and mCPBG and decreased when presented with antagonists azasetron and ondansetron. |
complete | |||||
|
enables |
GO:0022850 |
serotonin-gated cation-selective channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050877 |
nervous system process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87888 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95747 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95747 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042391 |
regulation of membrane potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87885 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95613 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003011 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000434994 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1861899 |
C |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0005230 |
extracellular ligand-gated ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000434994 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007210 |
serotonin receptor signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0022850 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005230 |
extracellular ligand-gated ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR006029 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR006029 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
Reactome:R-HSA-112315 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-975311 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Niesler, B et al. (2007) Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol. Pharmacol. 72 8-17 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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