HUMAN:2B1E

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HLA-DRB1
Protein Name(s)	HLA class II histocompatibility antigen, DRB1-14 beta chain MHC class II antigen DRB1*14 DR-14 DR14
External Links
UniProt	Q9GIY3
EMBL	AB062112 AJ297582 AJ297583 AJ297584 AJ297585 AY663408 AY935719 AY961071 DQ235685 DQ390459 DQ390460 FJ379259 Z38072 FM196525 AM109998 AM109999 AM110000 AM110001 AM110002 AM110003 AB485773 Z50730 AJ242985 AJ251985 AY050186 AY054375 AF400066 AY267905 AY267906 AJ969417 AY912075 DQ333353 AM259285 EF199810 AM774161 EF495154 AM922324 DQ494324 EU588391 D86502 D86504 D88310 AJ010982 AF172071 AJ543433 AY277390 AJ581744 AJ812566 AY770520 DQ021915 AM084908 DQ327711 DQ358688 AM233907 DQ643390 U95115 AM933133 EU545181 AB049830 AB049831 AB049832 AB087875 AB087876 AB436778 EF078986 EF536016 EU029787 EU029788 EU029792 EU029793 EU029798 EU643616 EU812536 EU924810 DQ060439 DQ060441 DQ782331 FM179681 FJ594768 AF177215 X99839 AJ289123 AY174092 AY174181 M77673 AF028010 AF112879 X86974 U41489 AJ508388
PIR	B33287 C33287 C60748 F60748 PH0157 PH0158 S03440
UniGene	Hs.485130 Hs.534322 Hs.696211 Hs.716081 Hs.723344 Hs.736560
ProteinModelPortal	Q9GIY3
SMR	Q9GIY3
IntAct	Q9GIY3
DMDM	74761361
PRIDE	Q9GIY3
Ensembl	ENST00000328980 ENST00000360004 ENST00000399450 ENST00000412634 ENST00000415796 ENST00000419393 ENST00000428566
GeneCards	GC06M032546 GC06Mj32477 GC06Mn32480 GC06Mo32637
HGNC	HGNC:4948
HPA	CAB015400 CAB034021
MIM	142857
neXtProt	NX_Q9GIY3
HOVERGEN	HBG012730
Reactome	REACT_121399 REACT_12555 REACT_12582 REACT_12596 REACT_12623 REACT_19324 REACT_25078
ChiTaRS	HLA-DRB1
Proteomes	UP000005640 UP000005640
Bgee	Q9GIY3
ExpressionAtlas	Q9GIY3
GO	GO:0030669 GO:0030666 GO:0012507 GO:0000139 GO:0071556 GO:0031902 GO:0005765 GO:0042613 GO:0005886 GO:0032588 GO:0030658 GO:0019886 GO:0019221 GO:0060333 GO:0031295 GO:0050852
Gene3D	2.60.40.10 3.10.320.10
InterPro	IPR007110 IPR013783 IPR003006 IPR003597 IPR011162 IPR014745 IPR000353
Pfam	PF07654 PF00969
ProDom	PD000328
SMART	SM00407 SM00921
SUPFAM	SSF54452
PROSITE	PS50835 PS00290

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0031902	late endosome membrane	PMID:18305173^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:18305173^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000353 InterPro:IPR014745	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000353 InterPro:IPR014745	C	Seeded From UniProt	complete
involved_in	GO:0019882	antigen processing and presentation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000353 InterPro:IPR014745	P	Seeded From UniProt	complete
part_of	GO:0042613	MHC class II protein complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000353 InterPro:IPR014745	C	Seeded From UniProt	complete
part_of	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	Reactome:R-HSA-8951500 Reactome:R-HSA-2213241 Reactome:R-HSA-2213239 Reactome:R-HSA-2130731 Reactome:R-HSA-2130478	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	Reactome:R-HSA-877300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032588	trans-Golgi network membrane	Reactome:R-HSA-8951498 Reactome:R-HSA-2213236 Reactome:R-HSA-2130641 Reactome:R-HSA-2130619 Reactome:R-HSA-2130393 Reactome:R-HSA-2130378	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030669	clathrin-coated endocytic vesicle membrane	Reactome:R-HSA-2130725 Reactome:R-HSA-2130486	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-2213235 Reactome:R-HSA-2130486	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030658	transport vesicle membrane	Reactome:R-HSA-2130500 Reactome:R-HSA-2130378	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Reactome:R-HSA-2132295	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0012507	ER to Golgi transport vesicle membrane	Reactome:R-HSA-2213243 Reactome:R-HSA-2130731	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8856157 Reactome:R-HSA-8855381 Reactome:R-HSA-8852200 Reactome:R-HSA-389758 Reactome:R-HSA-2213248 Reactome:R-HSA-2130725 Reactome:R-HSA-2130640 Reactome:R-HSA-2130500 Reactome:R-HSA-202344 Reactome:R-HSA-202307 Reactome:R-HSA-202291 Reactome:R-HSA-202248 Reactome:R-HSA-202245 Reactome:R-HSA-202233 Reactome:R-HSA-202216 Reactome:R-HSA-202214 Reactome:R-HSA-202174 Reactome:R-HSA-202168 Reactome:R-HSA-202165 Reactome:R-HSA-1031716	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	Reactome:R-HSA-2213248 Reactome:R-HSA-2213246 Reactome:R-HSA-2213244 Reactome:R-HSA-2213236 Reactome:R-HSA-2213235 Reactome:R-HSA-2130504 Reactome:R-HSA-2130349 Reactome:R-HSA-2130336	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-2213243 Reactome:R-HSA-2130393	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
involved_in	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0491	P	Seeded From UniProt	complete
part_of	GO:0042613	MHC class II protein complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0491	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C	Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0151	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 De Gassart, A et al. (2008) MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc. Natl. Acad. Sci. U.S.A. 105 3491-6 PubMed GONUTS page

[PMID:18305173-1] 1.0 ^1.1 De Gassart, A et al. (2008) MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc. Natl. Acad. Sci. U.S.A. 105 3491-6 PubMed GONUTS page

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HUMAN:2B1E

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