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HAEDC:F6KZW9

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Species (Taxon ID) Haemophilus ducreyi. (730)
Gene Name(s) mtrC (ECO:0000313 with EMBL:AEF33942.1)
Protein Name(s) MtrC (ECO:0000313 with EMBL:AEF33942.1)
External Links
UniProt F6KZW9
EMBL HQ712073
HQ712074
HQ712077
ProteinModelPortal F6KZW9
GO GO:0016020
GO:0030682
GO:0010628
GO:0055085
InterPro IPR006143
TIGRFAMs TIGR01730

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030682

evasion or tolerance of host defense response

PMID:21444663[1]

ECO:0000315

P

Figures 5 and 6 show the effect of mtrC deletion on resistance to the mammalian defenses LL-37 and beta defensin. The plasmid-complemented mutant was not significantly different from the parent.

complete
CACAO 5288

GO:0010628

positive regulation of gene expression

PMID:21444663[1]

ECO:0000315

P

Figure 4 shows the effect of mtrC deletion on mRNA levels of four CpxRA-regulated genes. The genes fimA and omp2B are known to be upregulated by CpxRA, while lspB and dsrA are downregulated by activation of the CpxRA regulation system. These results, combined with the information in Figure 3C, led the authors to conclude that the CpxRA system was activated in the mtrC deletion mutant.

complete
CACAO 5289

involved_in

GO:0030682

evasion or tolerance of host defense response

PMID:21444663[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:21444663[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005215

transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006143

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006143

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006143

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Rinker, SD et al. (2011) Deletion of mtrC in Haemophilus ducreyi increases sensitivity to human antimicrobial peptides and activates the CpxRA regulon. Infect. Immun. 79 2324-34 PubMed GONUTS page