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FMDVO:POLG
Contents
| Species (Taxon ID) | Foot-and-mouth disease virus (isolate Bovine/Germany/O1Kaufbeuren/1966serotype O) (FMDV). (73482) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Genome polyprotein
Leader protease Lpro Protein VP0 VP4-VP2 Protein VP4 P1A Virion protein 4 Protein VP2 P1B Virion protein 2 Protein VP3 P1C Virion protein 3 Protein VP1 P1D Virion protein 1 Protein 2A P2A P52 Protein 2B P2B Protein 2C P2C Protein 3A P3A Protein 3B-1 P3B-1 Genome-linked protein VPg1 Protein 3B-2 P3B-2 Genome-linked protein VPg2 Protein 3B-3 P3B-3 Genome-linked protein VPg3 Picornain 3C Protease 3C P3C Protease P20B RNA-directed RNA polymerase 3D-POL P3D-POL P56A | |
| External Links | ||
| UniProt | P03305 | |
| EMBL | X00871 J02185 | |
| PDB | 1QMY 1QOL 1QQP 2JQF 2JQG 4QBB | |
| PDBsum | 1QMY 1QOL 1QQP 2JQF 2JQG 4QBB | |
| DisProt | DP00573 | |
| ProteinModelPortal | P03305 | |
| SMR | P03305 | |
| MEROPS | C03.008 | |
| EvolutionaryTrace | P03305 | |
| Proteomes | UP000008765 | |
| GO | GO:0044162 GO:0019030 GO:0044385 GO:0016020 GO:0005524 GO:0004197 GO:0005216 GO:0003723 GO:0003724 GO:0003968 GO:0005198 GO:0075512 GO:0039520 GO:0039525 GO:0039707 GO:0051259 GO:0018144 GO:0039544 GO:0039611 GO:0006351 GO:0019082 GO:0039694 GO:0019062 | |
| Gene3D | 2.60.120.20 4.10.90.10 | |
| InterPro | IPR015031 IPR004080 IPR004004 IPR000605 IPR014759 IPR027417 IPR008739 IPR000199 IPR001676 IPR001205 IPR007094 IPR009003 IPR029053 | |
| Pfam | PF05408 PF00548 PF00680 PF00073 PF00910 PF08935 | |
| PRINTS | PR00918 PR01542 | |
| SUPFAM | SSF50494 SSF52540 | |
| PROSITE | PS50507 PS51218 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0019048 |
modulation by virus of host morphology or physiology |
ECO:0000315 |
P |
Figure 1. Expression and assembly of purified FMDV capsid proteins |
complete | |||||
| GO:0019048 |
modulation by virus of host morphology or physiology |
ECO:0000315 |
P |
Figure 4. The clinical outcome of cattle challenged with FMDV. |
complete | |||||
|
involved_in |
GO:0039520 |
induction by virus of host autophagy |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005216 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003724 |
RNA helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004197 |
cysteine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005198 |
structural molecule activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006351 |
transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019030 |
icosahedral viral capsid |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019082 |
viral protein processing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039694 |
viral RNA genome replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017111 |
nucleoside-triphosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039648 |
modulation by virus of host protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019785 |
ISG15-specific protease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039579 |
suppression by virus of host ISG15 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039644 |
suppression by virus of host NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039611 |
suppression by virus of host translation initiation factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039690 |
positive stranded viral RNA replication |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P03311:PRO_0000039890 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0044385 |
integral to membrane of host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039707 |
pore formation by virus in membrane of host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005216 |
ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018144 |
RNA-protein covalent cross-linking |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019062 |
virion attachment to host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006417 |
regulation of translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044161 |
host cell cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075509 |
endocytosis involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019065 |
receptor-mediated endocytosis of virus by host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051259 |
protein complex oligomerization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044165 |
host cell endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075512 |
clathrin-dependent endocytosis of virus by host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0039618 |
T=pseudo3 icosahedral viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016779 |
nucleotidyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039525 |
modulation by virus of host chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044167 |
host cell endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044162 |
host cell cytoplasmic vesicle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Guo, HC et al. (2013) Foot-and-mouth disease virus-like particles produced by a SUMO fusion protein system in Escherichia coli induce potent protective immune responses in guinea pigs, swine and cattle. Vet. Res. 44 48 PubMed GONUTS page
- ↑ Berryman, S et al. (2012) Foot-and-mouth disease virus induces autophagosomes during cell entry via a class III phosphatidylinositol 3-kinase-independent pathway. J. Virol. 86 12940-53 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 de Los Santos, T et al. (2007) Degradation of nuclear factor kappa B during foot-and-mouth disease virus infection. J. Virol. 81 12803-15 PubMed GONUTS page
- ↑ Wang, D et al. (2011) The leader proteinase of foot-and-mouth disease virus negatively regulates the type I interferon pathway by acting as a viral deubiquitinase. J. Virol. 85 3758-66 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Swatek, KN et al. (2018) Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proc. Natl. Acad. Sci. U.S.A. 115 2371-2376 PubMed GONUTS page
- ↑ Glaser, W & Skern, T (2000) Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro. FEBS Lett. 480 151-5 PubMed GONUTS page
c
h
- GO:0004386 ! helicase activity
- GO:0044161 ! host cell cytoplasmic vesicle
- GO:0030430 ! host cell cytoplasm
- GO:0044162 ! host cell cytoplasmic vesicle membrane
- GO:0044167 ! host cell endoplasmic reticulum membrane
- GO:0044165 ! host cell endoplasmic reticulum
- GO:0033644 ! host cell membrane
- GO:0042025 ! host cell nucleus
- GO:0016787 ! hydrolase activity
m
o
- GO:0044385 ! obsolete integral to membrane of host cell
- GO:0019048 ! obsolete modulation by virus of host process
- GO:0039611 ! obsolete suppression by virus of host translation initiation factor activity
- GO:0039644 ! obsolete suppression by virus of host NF-kappaB cascade
- GO:0039707 ! obsolete virus-mediated pore formation in host cell membrane
p
r
- GO:0019065 ! receptor-mediated endocytosis of virus by host cell
- GO:0006417 ! regulation of translation
- GO:0017111 ! ribonucleoside triphosphate phosphatase activity
- GO:0003968 ! RNA-dependent RNA polymerase activity
- GO:0018144 ! RNA-protein covalent cross-linking
- GO:0001172 ! RNA-templated transcription
- GO:0003723 ! RNA binding
- GO:0003724 ! RNA helicase activity
s
- ssRNA positive-strand viruses, no DNA stage
- GO:0005198 ! structural molecule activity
- GO:0039525 ! symbiont-mediated perturbation of host chromatin organization
- GO:0039520 ! symbiont-mediated activation of host autophagy
- GO:0039502 ! symbiont-mediated suppression of host type I interferon-mediated signaling pathway
- GO:0039579 ! symbiont-mediated suppression of host ISG15-protein conjugation
- GO:0039648 ! symbiont-mediated perturbation of host ubiquitin-like protein modification
- GO:0046718 ! symbiont entry into host cell
