ENTFA:Q834R2

Species (Taxon ID)	Enterococcus faecalis (strain ATCC 700802 / V583). (226185)
Gene Name(s)	folA (ECO:0000313 with EMBL:AAO81364.1)
Protein Name(s)	Dihydrofolate reductase (ECO:0000256 with PIRNR:PIRNR000194)
External Links
UniProt	Q834R2
EMBL	AE016830
RefSeq	NP_815294.1 WP_002360302.1
PDB	4M7U 4M7V
PDBsum	4M7U 4M7V
ProteinModelPortal	Q834R2
STRING	226185.EF1577
EnsemblBacteria	AAO81364
GeneID	1200477
KEGG	efa:EF1577
PATRIC	21853510
eggNOG	ENOG4108YYV COG0262
KO	K00287
OMA	DTQFPDW
OrthoDB	EOG6KT2V2
BioCyc	EFAE226185:GHI1-1563-MONOMER
UniPathway	UPA00077
Proteomes	UP000001415
GO	GO:0004146 GO:0050661 GO:0006545 GO:0009165 GO:0006730 GO:0046654
Gene3D	3.40.430.10
InterPro	IPR012259 IPR024072 IPR017925 IPR001796
Pfam	PF00186
PIRSF	PIRSF000194
PRINTS	PR00070
SUPFAM	SSF53597
PROSITE	PS00075 PS51330

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004146	dihydrofolate reductase activity	GO_REF:0000100	ECO:0000247		UniProtKB:A0A087LEM1	F		Blastp results showed the dihydrofolate reductase activity relating Enterococcus faecalis and Bacillus Stearothermophilus with 100% identity, 100% query cover, and an e-value of 7.2E-39	complete CACAO 12002
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR012259 InterPro:IPR017925	F		Seeded From UniProt	complete
involved_in	GO:0006545	glycine biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012259	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR012259	P		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012259	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR012259 InterPro:IPR017925	P		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.1.3	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0006730	one-carbon metabolic process	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0554	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00077	P		Seeded From UniProt	complete
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References

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